The efficacy and role ofanti-lipid mediators on pulmonary fibrosis

• Project/Area Number: 22590871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: FUKUNAGA Koichi 慶應義塾大学, 医学部, 講師 (60327517)
• Co-Investigator(Kenkyū-buntansha): ASANO Koichiro 慶應義塾大学, 医学部, 准教授 (60192944)
• Co-Investigator(Renkei-kenkyūsha): ARITA Makoto 東京大学, 大学院・薬学系研究科, 准教授 (80292952)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肺線維症 / 抗炎症性脂質メディエーター / 不飽和脂肪酸

Research Abstract

Pulmonary fibrosis is a progressive disease of unknown etiology and poor prognosis because there is no effective therapy. In the current study, using an experimental murine model of pulmonary fibrosis, EPA derived resolving E1 (RvE1) and high dose of EPA

Research Products

• [Journal Article] Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress. (2012)
  • Author(s): Takamiya R, Fukunaga K, Arita M et al.
  • Journal Title: FEBS Open Bio
  • Peer Reviewed
• [Journal Article] The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury. (2010)
  • Author(s): Fukunaga K, Seki H, Arita M, Levy BD et al.
  • Journal Title: J Immunol. Volume: 184(2) Pages: 836-43
  • Peer Reviewed
• [Presentation] The effect of anti-inflammatory lipid mediator, lipoxin A4, in a murine peritonitis model (2011)
  • Author(s): T Ueda-Arima, K Fukunaga
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-17
• [Presentation] Protectin D1 is a self-produced regulator of human eosinophil functions (2011)
  • Author(s): J Miyata, K Fukunaga
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-17
• [Presentation] 抗炎症性脂質メディエーターによる肺炎症性疾患の制御 (2010)
  • Author(s): 福永興壱
  • Organizer: 第33回日本血栓止血学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-04-22