Roles of small G protein Rap1 in acute respiratory failure and its therapeutic implication

• Project/Area Number: 22590872
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: TASAKA Sadatomo 慶應義塾大学, 医学部, 講師 (70276244)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 急性呼吸不全 / 低分子G蛋白 / 接着分子 / シグナル伝達 / 低分子Ｇ蛋白

Research Abstract

We evaluated the role of Rap1, which regulates the expression of CD11b and CD44, in the pathogenesis of acute respiratory failure. Inflammatory stimulus upregulated the gene expression of Rap1 in cultured endothelial and epithelial cells. In addition, upr

Research Products

• [Remarks]
  • URL: http://www.keio-med.jp/pulmonary/index.html