Protection by hydrogen therapy against oxidative stress induced various lung diseases.
| Project/Area Number |
22590873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHSAWA Ikuro 日本医科大学, 老人病研究所, 教授 (30343586)
FUKUDA Yuh 日本医科大学, 大学院・医学研究科, 教授 (60097037)
TERASAKI Mika 日本医科大学, 医学部, 助教 (50372785)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 酸化ストレス / 水素還元力 / 呼吸器疾患 / 水素抗酸化作用 / 放射線肺障害 / アポトーシス / ハイドロキシラジカル / クララ細胞 / ゲフィチニブ / ナフタレン / 抗酸化作用 |
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| Research Abstract |
Various lung injuries such as irradiation or anticancer drug induced injuries are reportedly initiated and sustained by oxidative stress (reactive oxygen species:ROS), especially hydroxyl radicals (-OH), which are the primary cause of the damage. As yet,no ideal ROS scavenge therapy has been established. Because H2 was recently reported as an efficient antioxidant that diffuses rapidly across cell membranes, selectively reduces -OH, and suppresses oxidative stress-induced injury with no known toxicity, we studied the possibility that H2 could protect against irradiation or anticancer drug induced lung damage. We show here that H2 scavenged -OH and protected against apoptotic damage related to oxidative stress induced by irradiation and anticancer drug in lung epithelial cells and in lungs of mice. H2 treatment will thus be valuable for protection against oxidative stress induced various lung diseases.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Immunoglobulin G4-related lung disease: clinicoradiological and pathological features.2013
Author(s)
Matsui S, Hebisawa A, Sakai F, Yamamoto H, Terasaki Y,,, Kurihara Y, Waseda Y, Kawamura T, Miyashita T, Inoue H, Hata N, Kawabata Y, Ogura T
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Journal Title
Respirology
Volume: 18
Issue: 3
Pages: 480-487
DOI
Related Report
Peer Reviewed
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[Journal Article] A mucin-rich variant of salivary duct carcinoma with a prominent mucinous component, a tumor that mimics mucinous adenocarcinoma: a case report2013
Author(s)
Mika Terasaki, Yasuhiro Terasaki, Kyoko Wakamatsu, Mikiko Takahashi, Shinobu Kunugi, Hirokazu Urushiyama, Atsuko Sakanushi, Kimihiro Okubo, Yuh Fukuda.
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Volume: Mar 16
Related Report
Peer Reviewed
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[Journal Article] Renal inflammatory changes in acute hepatic failure-associated acute kidney injury.2013
Author(s)
Shimizu A, Ishii E, Masuda Y, Sato A, Piao H, Kunugi S, Takahashi M, Terasaki M, Nagasaka S, Terasaki Y, Ohashi R, Morioka T, Fukuda Y.
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Journal Title
Am J Nephrol.
Volume: 37
Issue: 4
Pages: 378-88
DOI
Related Report
Peer Reviewed
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[Journal Article] Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress2011
Author(s)
Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, Amenomori S, Kaneko-Togashi M, Kuwahara N, Ishikawa A, Kamimura N, Ohta S, Fukuda Y
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 301(4)
Related Report
Peer Reviewed
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[Journal Article] Rapid Diffusion of Hydrogen Protects the Retina: Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury2010
Author(s)
Oharazawa, H., Igarashi, T., Yokota, T., Fujii, H., Suzuki, H., Machide, M., Takahashi, H., Ohta, S., and Ohsawa, I
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Journal Title
Invest.Ophthalmol. Vis. Sci
Volume: 51
Pages: 487-492
Related Report
Peer Reviewed
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[Presentation] Role of survivin on bleomycin-induced lung injury2012
Author(s)
Terasaki Y, Terasaki M, Urushiyama H, Nagasaka S, Takahash M, Kunugi S, Wakamatsu K, Ishikawa A, Kuwahara N, Fukuda Y.
Organizer
ATS (American Thoracic Society) International Conference2012
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Hydrogen therapy attenuates radiation-induced pulmonary injury in C57/Bl6 mice through reducing oxidative stress2010
Author(s)
Terasaki Y, Ohsawa I, Terasaki M, Kang D, Kuwahara N, Ishikawa, A, Takahashi M, Kunugi S, , Fukuda Y
Organizer
ATS International Conference
Place of Presentation
New Orleans, USA
Related Report
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