| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Research Abstract |
Lung cancers in never-smokers have unique miRNA expression profiles as a novel molecular characteristic. MiR-21 is a downstreameffector of the activated EGFR signaling pathway and can be a therapeutic target in lung cancers with and without EGFR mutations. MiR-138 on 3p21.33, a chromosomal region carrying a long-sought lung cancer suppressor gene, is downregulated in never-smoker cases. There is an inverse correlation between miR-138 and hTERTin never-smoker lung cancers. These miRNAs may play an oncogenic role in lung carcinogenesis and miR-21 is novel molecular targets in treatment of lung cancers in never-smokers.
|
