Molecular Characteristics and Regulations Associated with Lung Carcinogenesis in Never-Smoker

• Project/Area Number: 22590874
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Saitama Medical University
• Principal Investigator: OKANO Tetsuya 埼玉医科大学, 医学部, 講師 (00339376)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: マイクロ RNA / 非喫煙者肺がん / プロテオーム / マイクロRNA

Research Abstract

Lung cancers in never-smokers have unique miRNA expression profiles as a novel molecular characteristic. MiR-21 is a downstreameffector of the activated EGFR signaling pathway and can be a therapeutic target in lung cancers with and without EGFR mutations. MiR-138 on 3p21.33, a chromosomal region carrying a long-sought lung cancer suppressor gene, is downregulated in never-smoker cases. There is an inverse correlation between miR-138 and hTERTin never-smoker lung cancers. These miRNAs may play an oncogenic role in lung carcinogenesis and miR-21 is novel molecular targets in treatment of lung cancers in never-smokers.

Research Products

• [Journal Article] GemmaA Alternating chemotherapy with amrubicin plus cisplatin and weekly administration of irinotecan plus cisplatin for extensive-stage small cell lung cancer. (2013)
  • Author(s): Noro R, Yoshimura A, Yamamoto K, Miyanaga A, Mizutani H, Minegishi Y, Seike M, Kubota K, Kosaihira S, Hino M, Ando M, Nomura K, Okano T, Kobayashi K, Uematsu K
  • Journal Title: Anticancer Res. Volume: 33(3)巻 Pages: 1117-23
  • Peer Reviewed
• [Journal Article] Alternating chemotherapy with amrubicin plus cisplatin and weekly administration of irinotecan plus cisplatin for extensive-stage small cell lung cancer. (2013)
  • Author(s): Noro R
  • Journal Title: Anticancer Res. Volume: 33（3） Pages: 1117-23
  • Peer Reviewed
• [Journal Article] Gemma A Combination chemotherapy of alternating etoposide and carboplatin with weekly administration of irinotecan and cisplatin in extensive-stage small-cell lung cancer. (2012)
  • Author(s): Yoshimura A, Noro R, Miyanaga A, Mizutani H, Kosaihira S, Minegishi Y, Seike M, Hino M, Ando M, Nomura K, Okano T, Kobayashi K
  • Journal Title: Anticancer Res Volume: 32(10)巻 Pages: 4473-8
  • Peer Reviewed
• [Journal Article] Gemma A.Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules. (2012)
  • Author(s): Shimokawa T, Seike M, Soeno C, Uesaka H, Miyanaga A, Mizutani H, Kitamura K, Minegishi Y, Noro R, Okano T, Yoshimura A
  • Journal Title: Br J Cancer. Volume: 106巻 Pages: 867-75
  • Peer Reviewed
• [Journal Article] Dissociative stupor mimicking consciousness disorder in an advanced lung cancer patient. (2012)
  • Author(s): Tada Y, Okano T, Kaga A, Yamazaki S, Kawada S, Ishida M, Kobayashi K, Onishi H.
  • Journal Title: Jpn J Clin Oncol. Volume: 42(6)巻 Issue: 6 Pages: 548-51
  • DOI: 10.1093/jjco/hys053
  • Peer Reviewed
• [Journal Article] Successful treatment of carcinomatous meningitis with erlotinib and whole brain radiotherapy. (2012)
  • Author(s): Rinako Ishikawa, Tetsuya Okano, Nobuyuki Koyama, Erika Saito, Akiko Kaga , Harue Utsugi, Tomohiko Mio, Hisayoshi Daito, Yuri Maeno, Yuka Uchida, Yoshiaki Nagai, Yoshitake Murayama, Kunihiko Kobayashi
  • Journal Title: Ann. Cancer Res. Ther. Volume: 20(2)巻 Pages: 58-62
  • NAID: 130002068759
  • Peer Reviewed
• [Journal Article] Combination chemotherapy of alternating etoposide and carboplatin with weekly administration of irinotecan and cisplatin in extensive-stage small-cell lung cancer. (2012)
  • Author(s): Yoshimura A
  • Journal Title: Anticancer Res. Volume: 32(10) Pages: 4473-8
  • Peer Reviewed
• [Journal Article] Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules (2012)
  • Author(s): Shimokawa T, Seike M, Soeno C, Uesaka H, Miyanaga A, Mizutani H, Kitamura K, Minegishi Y, Noro R, Okano T, Yoshimura A, Gemma A
  • Journal Title: Br J Cancer Volume: 106(5) Issue: 5 Pages: 867-75
  • DOI: 10.1038/bjc.2012.7
  • Peer Reviewed
• [Journal Article] Successful treatment of carcinomatous meningitis with erlotinib and whole brain radiotherapy. (2012)
  • Author(s): Rinako I
  • Journal Title: Ann. Cancer Res. Ther. Volume: 20(2) Pages: 58-62
  • Peer Reviewed
• [Journal Article] The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias. (2011)
  • Author(s): Minegishi Y, Kuribayashi H, Kitamura K, Mizutani H, Kosaihira S, Okano T, Seike M, Azuma A, Yoshimura A, Kudoh S, Gemma A.
  • Journal Title: J Thorac Oncol. Volume: 6(4)巻 Pages: 801-7
  • Peer Reviewed
• [Journal Article] The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias (2011)
  • Author(s): Minegishi Y, Kuribayashi H, Kitamura K, Mizutani H, Kosaihira S, Okano T, Seike M, Azuma A, Yoshimura A, Kudoh S, Gemma A
  • Journal Title: J Thorac Oncol Volume: 6(4) Issue: 4 Pages: 801-7
  • DOI: 10.1097/jto.0b013e3182103d3c
  • Peer Reviewed
• [Journal Article] 2010 Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression Cancer Sci. (2010)
  • Author(s): Noro R, Miyanaga A, Minegishi Y, Okano T, Seike M, Soeno C, Kataoka K, Matsuda K, Yoshimura A, Gemma A.
  • Journal Title: Cancer Sci. Volume: 6巻 Pages: 1424-30
  • Peer Reviewed
• [Journal Article] Gemma A.HSP27 modulates epithelial to mesenchymal transition of lung cancer cells in a Smad-independent manner (2010)
  • Author(s): Mizutani H, Okano T, Minegishi Y, Matsuda K, Sudoh J, Kitamura K, Noro R, Soeno C, Yoshimura A, Seike M
  • Journal Title: ONCOLOGY LETTERS Volume: 6巻 Pages: 1011-1016
  • Peer Reviewed
• [Journal Article] 肺癌の現状について (2010)
  • Author(s): 岡野 哲也
  • Journal Title: 都臨技会誌 Volume: 5巻 Pages: 391-400
• [Journal Article] Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression (2010)
  • Author(s): Noro R.
  • Journal Title: Cancer Sci. Volume: 6巻 Pages: 1424-90
  • Peer Reviewed
• [Journal Article] HSP27 modulates epithelial to mesenchymal transition of lung cancer cells in a Smad-independent manner (2010)
  • Author(s): Hideaki Mizutani
  • Journal Title: ONCOLOGY LETTERS Volume: 6巻 Pages: 1011-1016
  • Peer Reviewed
• [Presentation] 非喫煙者肺がんにおける発癌分子機構の解明 (2012)
  • Author(s): 岡野 哲也
  • Organizer: 第53回 日本肺癌学会総会
  • Place of Presentation: 岡山市
• [Presentation] 非喫煙者肺がんにおける発癌分子機構の解明 (2012)
  • Author(s): 岡野 哲也
  • Organizer: 第53 回 日本肺癌学会総会
  • Place of Presentation: 岡山市
• [Presentation] EGFR をめぐる基礎研究の展開 (2011)
  • Author(s): 岡野 哲也
  • Organizer: 第9回日本臨床腫瘍学会学術集会シンポジウム 2
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-07-22
• [Presentation] EGFRをめぐる基礎研究の展開 (2011)
  • Author(s): 岡野哲也
  • Organizer: 第9回日本臨床腫瘍学会学術集会シンポジウム2
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-07-22
• [Presentation] 肺がんの多段階発がんについての網羅的機能解析 (2010)
  • Author(s): 岡野 哲也
  • Organizer: 第78回日本医科大学医学会総会
  • Place of Presentation: 日本医科大学(東京都)
  • Year and Date: 2010-09-04