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Development of early diagnosis and disease stage evaluation method using ribosomal RNA gene in respiratory bacterial infectious diseases

Research Project

Project/Area Number 22590875
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

HOSHINO Yoshihiko  国立感染症研究所, ハンセン病研究センター 感染制御部, 室長 (20569694)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords呼吸器感染症 / 抗酸菌 / 全ゲノム解析 / 新興・再興感染症 / 定量的PCR / T-RFLP / リボゾームRNA / 16SrRNA / 16S rRNA
Research Abstract

We developed rapid diagnosis and disease stage evaluation method for pulmonary bacterial infection. Especially we focused pulmonary mycobacterial infection in this study. Principally, 16S ribosomal RNA (rRNA) gene was targeted and other genes such as internal transcribed spacer (ITS), heat shock protein 65 (hsp65), and RNA polymerase beta subunit (rpoB) were adjunctively utilized. We noticed the similarity of 16S rRNA genes among mycobacteria species and the necessity of combination of other genes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (65 results)

All 2013 2012 2011 2010

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (34 results) Book (4 results)

  • [Journal Article] Buruli ulcer and mycolactone producing mycobacteria.2013

    • Author(s)
      Nakanaga K, Yotsu RR, Hoshino Y, Suzuki K, Makino M, Ishii N
    • Journal Title

      Japan Journal of Infectious Diseases

      Volume: 66 Pages: 83-88

    • NAID

      130003381664

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laboratory procedures for the detection and identification of cutaneous non-tuberculous mycobacterial infections.2013

    • Author(s)
      Nakanaga K, Hoshino Y, Yotsu RR, Makino M, Ishii N
    • Journal Title

      Journal of Dermatology

      Volume: 40 Pages: 151-159

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laboratory procedures for the detection and identification of cutaneous non-tuberculousmycobacterial infections2013

    • Author(s)
      Nakanaga K
    • Journal Title

      The Journal of Dermatology

      Volume: 40 Issue: 3 Pages: 151-159

    • DOI

      10.1111/1346-8138.12047

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multidrug-resistant Tuberculosis with a History of Nontuberculous Mycobacteriosis: A Brief Report of Two Cases.2013

    • Author(s)
      Morimoto K
    • Journal Title

      Internal Medicine

      Volume: 51 Pages: 3435-3437

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-Type lectin is an FcRr-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor2013

    • Author(s)
      Miyake Y, Ynmasaki S, et al.
    • Journal Title

      Immunity

      Volume: 38 Issue: 5 Pages: 1050-62

    • DOI

      10.1016/j.immuni.2013.03.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacteremia due to Mycobacterium massiliense in a patient with chronic myelogenous leukemia:2012

    • Author(s)
      Hamamoto T, Yuki A, Naoi K, Kawakami S, Banba Y, Yamamura T, Hikota R, Watanabe J, Kimura F, Nakanaga K, Hoshino Y, Ishii N, Shimazaki H, Nakanishi K, Tamai S.
    • Journal Title

      Diagnostic Microbiology and Infectious Disease

      Volume: 74(2) Pages: 183-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Mycobacterial Skin Disease Caused by Mycobacterium peregrinum, and a Review of Cutaneous Infection.2012

    • Author(s)
      Kamijo F, Uhara H, Kubo H, Nakanaga K, Hoshino Y, Ishii N, Okuyama R
    • Journal Title

      Case Reports in Dermatology

      Volume: 4(1) Pages: 76-9

    • NAID

      120007100122

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Buruli Ulcer and Current Situation in Japan: a new emerging cutaneous Mycobacterium infection.2012

    • Author(s)
      Yotsu RR, Nakanaga K, Hoshino Y, Suzuki K, Ishii1 N
    • Journal Title

      The Journal of Dermatology

      Volume: 39(7) Pages: 587-93

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Buruli ulcer accompanied by pain in a Japanese patient.2012

    • Author(s)
      Onoe H, Nakanaga K, Yotsu R, Hoshino Y, Ishii N, Takeuchi T
    • Journal Title

      The Journal of Dermatology

      Volume: 39(10) Pages: 869-70

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium pseudoshottsii isolated from 24 farmed fishes in western Japan.2012

    • Author(s)
      Nakanaga K, Hoshino Y, Hattori Y, Yamamoto A, Wada S, Hatai K, Makino M, Ishii N
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 74 Pages: 275-278

    • NAID

      130001190609

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium shigaense sp. nov., a novel slowly growing scotochromogenic mycobacterium that produced nodules in an erythroderma patient with severe cellular immunodeficiency and a history of Hodgkin's disease.2012

    • Author(s)
      Nakanaga K, Hoshino Y, Wakabayashi M, Fujimoto N, Tortoli E, Makino M, Tanaka T, Ishii N
    • Journal Title

      The Journal of Dermatology

      Volume: 39(4) Pages: 389-96

    • NAID

      10031184913

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 浸潤性胸腺腫・重症筋無力症治療中に発症したMycobacteirum massilienseによる播種性非結核性抗酸菌症の一例2012

    • Author(s)
      竹村佳純、上田幹雄、中西雅樹、小森敏明、藤田直久、中永和枝、星野仁彦、石井則久、岩崎吉伸
    • Journal Title

      呼吸

      Volume: 31(11) Pages: 1070-1076

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium massiliense皮膚感染症の1例2012

    • Author(s)
      今長慶志、星野洋良、藤本典宏、小林孝志、多島新吾、中永和枝、星野仁彦、石井則久
    • Journal Title

      皮膚臨床

      Volume: 54 Pages: 1207-1211

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous Mycobacterium massiliense infection: a sporadic case in Japan.2012

    • Author(s)
      Otsuki T, Izaki S, Nakanaga K, Hoshino Y, Ishii N, and Osamura K
    • Journal Title

      The Journal of Dermatology

      Volume: 39(6) Pages: 569-72

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Buruli ulcer accompanied by pain in a Japanese patient.2012

    • Author(s)
      Onoe H
    • Journal Title

      The Journal of Dermatology

      Volume: 39 Issue: 10 Pages: 869-870

    • DOI

      10.1111/j.1346-8138.2011.01430.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Buruli ulcer and current situation in Japan: A new emerging cutaneous Mycobacterium infection2012

    • Author(s)
      Rie Yotsu
    • Journal Title

      Journal of Dermatology

      Volume: 39 Issue: 7 Pages: 587

    • DOI

      10.1111/j.1346-8138.2012.01543.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Mycobacterial Skin Disease Caused by Mycobacterium peregrinum, and a Review of Cutaneous Infection2012

    • Author(s)
      Fuminao Kamijyo
    • Journal Title

      Case reports in dermatology

      Volume: 4 Issue: 1 Pages: 76-79

    • DOI

      10.1159/000337825

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacteremia due to Mycobacterium massiliense in a patient with chronic myelogenous leukemia: case report.2012

    • Author(s)
      Hamamoto T
    • Journal Title

      Diagn Microbiol Infect Dis

      Volume: 74 Issue: 2 Pages: 183-185

    • DOI

      10.1016/j.diagmicrobio.2012.06.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium pseudoshottsii Isolated from 24 Farmed Fishes in Western Japan2012

    • Author(s)
      Kazue Nakanaga
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 74 Issue: 2 Pages: 275-278

    • DOI

      10.1292/jvms.11-0226

    • NAID

      130001190609

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nineteen cases of Buruli ulcer diagnosed during 1980-2010 in Japan.2011

    • Author(s)
      Nakanaga K, Hoshino Y, Yotsu RR, Makino M, Ishii N
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 49 Pages: 3829-3836

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple cases of cutaneous Mycobacterium massiliense infection in a "hot spa" in Japan.2011

    • Author(s)
      Nakanaga K, Hoshino Y, Era Y, Matsumoto K, Kanazawa Y, Tomita A, Furuta M, Washizu M, Makino M, Ishii N
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 49(2) Pages: 613-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多剤併用療法が奏効したブルーリ潰瘍(Mycobacterium ulcerans subsp. shinshuense感染症)の一例2011

    • Author(s)
      湊はる香、若狭朋子、松村由美、中永和枝、星野仁彦、石井則久
    • Journal Title

      皮膚科の臨床

      Volume: 53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nineteen cases of Buruli ulcer diagnosed during 1980-2010 in Japan2011

    • Author(s)
      Kazue Nakanaga
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 49 Issue: 11 Pages: 3829-3836

    • DOI

      10.1128/jcm.00783-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous Mycobacterium massiliense infection : a sporadic case in Japan2011

    • Author(s)
      Takashi Otsuki
    • Journal Title

      Journal of Dermatology

      Volume: 39 Issue: 6 Pages: 569-572

    • DOI

      10.1111/j.1346-8138.2011.01339.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium shigaense sp.nov., a novel slowly growing scotochromogenic mycobacterium that produced nodules in an erythroderma patient with severe cellular immunodeficiency and a history of Hodgkin's disease2011

    • Author(s)
      Kazue Nakanaga
    • Journal Title

      Journal of Dermatology

      Volume: 39 Issue: 4 Pages: 389-396

    • DOI

      10.1111/j.1346-8138.2011.01355.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple cases of cutaneous Mycobacterium massiliense infection in a "hot spa" in Japan.2011

    • Author(s)
      Kazue Nakanaga
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 49 Pages: 613-617

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophils Activate Alveolar Macrophages by producing Caspase-6 Mediated Cleavage of Interleukin-1 Associated Kinase-M (IRAK-M).2011

    • Author(s)
      Hiroshi Kobayashi
    • Journal Title

      Journal of immunology

      Volume: 186 Pages: 403-410

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mycobacterium abscessusとMycobacterium massilienseのmultiple PCR法による迅速鑑別の検討2013

    • Author(s)
      榊原ゆみ、中永和枝、森本耕三、佐々木結花、倉島篤行、永井英明、藤原宏、長谷川直樹、松本智成、稲瀬直彦、牧野正彦、石井則久、星野仁彦
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム 東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 迅速発育菌M. abscessus, M.massilienseの薬剤感受性2013

    • Author(s)
      星野仁彦、深野華子、中永和枝、森本耕三、矢野量三、尾形英雄、工藤翔二、倉島篤行
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2012 Final Research Report
  • [Presentation] Mycobacterium avium complex感染における宿主マクロファージinducible C-type lectin (mincle)を介した自然免疫応答の解析(ミニシンポジウム)2013

    • Author(s)
      榊原ゆみ、稲瀬直彦、星野仁彦
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム 東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Mycobacterium abscessus groupの比較ゲノム解析(ミニシンポジウム)2013

    • Author(s)
      星野仁彦、甲斐雅規、中田登、関塚剛史、竹内史比古、牧野正彦、石井則久、黒田誠
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム 東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺MAC症におけるバイオマーカー(抗GPL-IgA抗体、好中球上CD64抗原、活性化ビタミンD,Cathelicidin:LL-37)の有用性についての検討2013

    • Author(s)
      森本耕三、榊原ゆみ、星野仁彦、吉山崇、久世眞之、奥村昌夫、佐々木結花、吉森浩三、尾形英雄、工藤翔二、倉島篤行
    • Organizer
      第88回日本結核病学会総会
    • Place of Presentation
      幕張メッセ国際会議場 千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] Mycobacterium massilienseの完全長ゲノム解析とM.abscessus group間の比較解析2013

    • Author(s)
      星野仁彦、中永和枝、鹿住祐子、前田伸司、石井則久
    • Organizer
      第88回日本結核病学会総会
    • Place of Presentation
      幕張メッセ国際会議場 千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗酸菌感染症におけるmacrophage inducible C-type lectin (mincle)の発現2013

    • Author(s)
      榊原ゆみ、森本耕三、吉山崇、倉島篤行、藤原永年、稲瀬直彦、石井則久、星野仁彦
    • Organizer
      第88回日本結核病学会総会
    • Place of Presentation
      幕張メッセ国際会議場 千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] Receptor of trehalose di-mycolate (TDM), mincle (macrophage inducible c-type lectin) determined the susceptibility of mycobacterium tuberculosis.2012

    • Author(s)
      Y Hoshino
    • Organizer
      EMBO conference "Tuberculosis 2012: biology, pathogenesis, intervention strategies"
    • Place of Presentation
      Institut Pasteur (Paris France)
    • Related Report
      2012 Final Research Report
  • [Presentation] 単一病院での過去25年間の肺MAC症における菌側因子の変遷について2012

    • Author(s)
      星野仁彦、深野華子、中永和枝、森本耕三、鹿住祐子、前田伸司、和田新平、奥村昌夫、吉山崇、尾形英雄、工藤翔二、倉島篤行
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺MAC症の菌側因子の解析2012

    • Author(s)
      森本耕三、星野仁彦、前田伸司、吉山崇、尾形英雄、倉島篤行、工藤翔二
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] MAC菌感染症に対するex vivo薬剤感受性試験2012

    • Author(s)
      星野仁彦、深野華子、中永和枝、森本耕三、吉山崇、尾形英雄、工藤翔二、和田新平、倉島篤行
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺MAC症における抗GPL抗体、好中球上CD64抗原および血中TREM-1と定量的画像分析による画像スコアとの関連についての検討2012

    • Author(s)
      森本耕三、星野仁彦、吉山崇、吉森浩三、奥村昌夫、尾形英雄、工藤翔二、倉島篤行
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト非結核性抗酸菌症の起因菌と類似した抗酸菌による水棲動物の疾患2012

    • Author(s)
      和田新平、深野華子、中永和枝、星野仁彦
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] 迅速発育抗酸菌による皮膚疾患2症例と海洋生物から分離された迅速発育抗酸菌の比較検討2012

    • Author(s)
      深野華子、中永和枝、星野仁彦、石井則久、和田新平
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] 本邦の"M.ulcerans subsp. shinshuense"を起因菌とするブルーリ潰瘍症例の増加2012

    • Author(s)
      中永和枝、星野仁彦、石井則久
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] 迅速発育菌M. abscessusとM. massilienseの薬剤感受性について2012

    • Author(s)
      星野仁彦、深野華子、中永和枝、和田新平、石井則久
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] マルチプレックスPCR法を用いたM. massilienseとM. abscessus鑑別診断法2012

    • Author(s)
      中永和枝、星野仁彦、石井則久
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] M. massilienseの全ゲノムシークエンス2012

    • Author(s)
      星野仁彦、中永和枝、鹿住祐子、前田伸司、石井則久
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場 広島
    • Related Report
      2012 Final Research Report
  • [Presentation] M. massilienseの全ゲノムシークエンス2012

    • Author(s)
      星野仁彦
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] マルチプレックスPCR法を用いたM. massilienseとM. abscessus鑑別診断法の開発2012

    • Author(s)
      中永和枝
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] M. abscessusとM. massilienseの薬剤感受性について2012

    • Author(s)
      星野仁彦
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 本邦の“M.ulcerans subsp. shinshuense”を起因菌とするブルーリ潰瘍症例の増加2012

    • Author(s)
      中永和枝
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 迅速発育抗酸菌による皮膚疾患2症例と海洋生物から分離された迅速発育抗酸菌の比較検討2012

    • Author(s)
      深野華子
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト非結核性抗酸菌症の起因菌と類似した抗酸菌による水棲動物の疾患2012

    • Author(s)
      和田新平
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺MAC症における抗GPL抗体、好中球上CD64抗原および血中TREM-1と定量的画像分析による画像スコアとの関連についての検討2012

    • Author(s)
      森本耕三
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] MAC菌感染症に対するex vivo薬剤感受性試験2012

    • Author(s)
      星野仁彦
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺MAC症の菌側因子の解析2012

    • Author(s)
      森本耕三
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 単一病院での過去25年間の肺MAC症における菌側因子の変遷について2012

    • Author(s)
      星野仁彦
    • Organizer
      第87回日本結核病学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] ブルーリ潰瘍原因菌であるMycobacterium shinshuenseが持つ毒性脂質合成酵素coding plasmid pMUM001自然欠損変異株に対する全ゲノムシークエンス解析2012

    • Author(s)
      中永和枝
    • Organizer
      文部科学省新学術領域「ゲノム支援」研究班拡大班会議
    • Place of Presentation
      御殿場高原ホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Receptor of traholose di-mycolate (TDM), mincle (macrophage inducible c-type lectin) determined the susceptibility of mycobacterium tuberculosis.2012

    • Author(s)
      Yoshihiko Hoshino
    • Organizer
      EMBO conference “Tuberculosis 2012: biology, pathogenesis, intervention strategies”
    • Place of Presentation
      Institut Pasteur (Paris France)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 日本人のGenetic backgroundとIGRA2011

    • Author(s)
      星野仁彦
    • Organizer
      第86回日本結核病学会
    • Place of Presentation
      日本教育会館
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nineteen cases of Buruli ulcer diagnosed during 1980-2010 in Japan.2011

    • Author(s)
      K Nakanaga, Y Hoshino, M.Makino
    • Organizer
      US-JAPAN cooperative medical science program 46^<th> tuberculosis and leprosy research conference
    • Place of Presentation
      OMIYA, JAPAN
    • Related Report
      2012 Final Research Report
  • [Presentation] 多剤耐性結核に対するインタフェロンガンマー吸入療法2010

    • Author(s)
      星野仁彦
    • Organizer
      第21回抗酸菌セミナー
    • Place of Presentation
      国立感染症研究所ハンセン病研究センター
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIV/TB in the lung:臨床研究と基礎研究のクスオーバー2010

    • Author(s)
      星野仁彦
    • Organizer
      第一回結核研究会
    • Place of Presentation
      結核研究所
    • Year and Date
      2010-04-06
    • Related Report
      2010 Annual Research Report
  • [Book] 肺MAC症診療Up to Date 各論I-4 肺MAC症とサイトカイン2013

    • Author(s)
      星野仁彦
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 肺MAC症診療 Up to Date2013

    • Author(s)
      星野仁彦
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Book] 病態のしくみがわかる免疫学2011

    • Author(s)
      星野仁彦
    • Total Pages
      296
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] 病態のしくみがわかる免疫学 III. 疾患や病態にかかわる免疫(臨床と免疫)8.肺疾患 e. AIDS合併結核の分子生物学的機序2010

    • Author(s)
      星野仁彦
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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