Analysis of T helper (Th) cell responses in immune complex nephritis with Th1/Th2/Th17 dominant mice

Research Project

Project/Area Number	22590876
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Kidney internal medicine
Research Institution	University of Tsukuba
Principal Investigator	YOH Keigyou 筑波大学, 医学医療系, 准教授 (90323302)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	腎臓学 / Th17細胞 / 免疫複合体腎炎 / ヘルパーT細胞 / Th1/Th2
Research Abstract	To clarify the roles of helper T cell in immune complex glomerulonephritis, we induced experimental immune complex glomerulonephritis in Th1/2/17 dominant transgenic mice. Th17 dominant transgenic mice showed higher volume of proteinuria than other mice, and developed crescentic glomerulonephritis. These results suggested that Th17 might play an important role in the development of immune complex glomerulonephritis.

Report

(4 results)