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Expression profile of miRNA in chronic kidney disease and identification of miRNA regulating hypoxia and endoplasmic reticulum stress signals

Research Project

Project/Area Number 22590880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

INAGI Reiko  東京大学, 医学部附属病院, 特任研究員 (50232509)

Co-Investigator(Kenkyū-buntansha) NANGAKU Masaomi  東京大学, 医学部附属病院, 教授 (90311620)
WADA Takehiko  東京大学, 医学部附属病院, 助教 (90447409)
OHSE Takamoto  東京大学, 医学部附属病院, 助教 (10568447)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords小胞体ストレス / 尿細管 / unfolded protein response / 虚血 / 酸化ストレス / 翻訳制御 / microRNA / 腎臓病 / UPR経路 / 酸化ストリス / 腎臟病
Research Abstract

To assess the pathophysiological function of microRNA (miRNA) inchronic kidney disease (CKD), we performed the miRNA microarray analysis and the loss/gainfunction assay in human tubular cells (HK-2) expose to hypoxia-induced oxidative stressor endoplasmic reticulum (ER) stress. The results demonstrated that 1) miR-205 expressionwas significantly decreased by hypoxia-induced oxidative stress or ER stress and wasassociated with cellular sensitivity to the stresses, 2) PHD1, which degradestranscription factors (HIF, ATF4) of hypoxia and ER stress signals, is a target for miR-205,3) decreased miR-205 suppressed the expression of HIF/ATF4 downstream genes, anti-oxidantenzymes, via upregulation of PHD1. miR-205 might contribute to tubular homeostasis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (86 results)

All 2013 2012 2011 2010 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (53 results) (of which Invited: 5 results) Book (11 results) Remarks (1 results)

  • [Journal Article] Endoplasmic reticulum stress signal impairs erythropoietin production:a role for ATF4.2013

    • Author(s)
      Chiang CK, Nangaku M, Tanaka T, IwawakiT, Inagi R.
    • Journal Title

      Am J Physiol Cell Physiol.

      Volume: 304(4) Issue: 4 Pages: C342-C353

    • DOI

      10.1152/ajpcell.00153.2012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.2012

    • Author(s)
      Muratsu-Ikeda S, Nangaku M, Ikeda Y,Tanaka T, Wada T, Inagi R.
    • Journal Title

      PLoS One.

      Volume: 7(7) Issue: 7 Pages: e41462-e41462

    • DOI

      10.1371/journal.pone.0041462

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glyoxalase I retards renalsenescence.2011

    • Author(s)
      Ikeda Y, Inagi R, Miyata T, Nagai R, AraiM, Miyashita M, Itokawa M, Fujita T,Nangaku M.
    • Journal Title

      Am J Pathol.

      Volume: 179(6) Issue: 6 Pages: 2810-21

    • DOI

      10.1016/j.ajpath.2011.08.023

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner2011

    • Author(s)
      Chiang CK, Tanaka T, Inagi R, Fujita T, Nangaku M
    • Journal Title

      Lab Invest

      Volume: 91 Issue: 11 Pages: 1564-71

    • DOI

      10.1038/labinvest.2011.114

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitors of advanced glycation and endoplasmic reticulum stress.2011

    • Author(s)
      Inagi R.
    • Journal Title

      Methods Enzymol.

      Volume: 491 Pages: 361-80

    • DOI

      10.1016/b978-0-12-385928-0.00020-1

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.2011

    • Author(s)
      Nishi H, Inagi R, Kawada N, YoshizatoK, Mimura I, Fujita T, Nangaku M.
    • Journal Title

      Am J Pathol.

      Volume: 178(1) Issue: 1 Pages: 128-39

    • DOI

      10.1016/j.ajpath.2010.11.011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glyoxalase I retards renal senescence2011

    • Author(s)
      Ikeda Y, et al.
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 2810-21

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitors of advanced glycation and endoplasmic reticulum stress2011

    • Author(s)
      Inagi R
    • Journal Title

      Methods Enzymol

      Volume: 491 Pages: 361-80

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions2011

    • Author(s)
      Nishi H, et al.
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 128-39

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitor of advanced glycation and endoplasmic reticulum stress.2011

    • Author(s)
      Inagi R
    • Journal Title

      Method Enzymol

      Volume: 491C Pages: 361-380

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novelglobin, plays an anti-fibrotic role in the kidney2010

    • Author(s)
      Mimura I, Nangaku M, Nishi H, Inagi R, Tanaka T, Fujita T
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299 Issue: 5 Pages: F1120-F1133

    • DOI

      10.1152/ajprenal.00145.2010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular diseases : genetic causes and future therapeutics2010

    • Author(s)
      Chiang CK, Inagi R
    • Journal Title

      NatRev Nephrol 6

      Volume: 6(9) Issue: 9 Pages: 539-54

    • DOI

      10.1038/nrneph.2010.103

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress2010

    • Author(s)
      Kawakami T, Inagi R, Wada T, Tanaka T, Fujita T, Nangaku M
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299 Issue: 3 Pages: F568-F576

    • DOI

      10.1152/ajprenal.00659.2009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of glyoxalase system in renal hypoxia2010

    • Author(s)
      Inagi R, Kumagai T, Fujita T, Nangaku M
    • Journal Title

      Adv Exp Med Biol

      Volume: 662 Pages: 49-55

    • DOI

      10.1007/978-1-4419-1241-1_6

    • ISBN
      9781441912398, 9781441912411
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress as a progression factor for kidney injury.2010

    • Author(s)
      Inagi R.
    • Journal Title

      Curr Opin Pharmacol.

      Volume: 10(2) Issue: 2 Pages: 156-65

    • DOI

      10.1016/j.coph.2009.11.006

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress as a progression factor for kidney injury.2010

    • Author(s)
      Inagi R
    • Journal Title

      Curr Opin Pharmacol

      Volume: 10 Pages: 156-165

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of glyoxalase system in renal hypoxia.2010

    • Author(s)
      Inazi R, et al.
    • Journal Title

      Adv Exp Med Biol

      Volume: 662 Pages: 49-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress.2010

    • Author(s)
      Kawakami T, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel globin, plays an antifibrotic role in the kidney.2010

    • Author(s)
      Mimura I, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular diseases : Genetic causes and future therapeutics.2010

    • Author(s)
      Chiang CK, Inagi R
    • Journal Title

      Nat Review Nephrol

      Volume: 6 Pages: 539-554

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.2010

    • Author(s)
      Nishi H, et al.
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 128-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Endoplasmic Reticulum (ER) Stress and the progression of kidney Disease.2013

    • Author(s)
      Reiko Inagi
    • Organizer
      Lecture in Chulalongkorn University
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2013-02-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Endoplasmic Reticulum (ER) Stress and the progression of kidney disease2013

    • Author(s)
      Reiko Inagi
    • Organizer
      Lecture in Chulalongkorn University
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Glyoxalase I retards renal senescence. -Glycative stress as a mediator of renal senescence-2012

    • Author(s)
      Reiko Inagi (Invited)
    • Organizer
      Molecular and Cellularbiology of Aging The 34th Japan Society for Biomedical Gerontology symposium
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2012-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Endoplasmic Reticulum Stress and kidney disease.2012

    • Author(s)
      Reiko Inagi (Invited)
    • Organizer
      INSERM seminar
    • Place of Presentation
      Paris,France
    • Year and Date
      2012-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Glycative stress as a progressive factor for kidney disease and renal senescence. -A rolefor glyoxalase I-2012

    • Author(s)
      Reiko Inagi (Invited)
    • Organizer
      Annual Conference of the Korean Society for Gerontology (the 12th Korea-Japan joint symposia)
    • Place of Presentation
      Osong, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム:オルガネラと腎障害の密接な関係を紐解くー小胞体ストレスと腎障害-2012

    • Author(s)
      稲城玲子
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規HIF-1ターゲット分子SPAG4は尿細管の細胞質分裂を調節する2012

    • Author(s)
      正路久美、他
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム:オルガネラと腎障害の密接な関係を紐解く ー小胞体ストレスシグナルと腎障害ー2012

    • Author(s)
      稲城玲子
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] microRNAによるprolyl hydroxylase domain 1 (PHD1) の転写後制御を介した腎尿細管細胞のストレス応答調節機構2012

    • Author(s)
      村津四葉、他
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小胞体ストレスシグナル (unfolded protein response) による低酸素応答性エリスロポエチン産生機構の破綻2012

    • Author(s)
      Chiang CK, et al.
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] カルボニルストレス制御による血管内皮機能障害と血管老化の軽減2012

    • Author(s)
      城愛理、他
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glycative stress as a progressive factor for kidney disease and renal senescence - A role for glyoxalase I -2012

    • Author(s)
      Reiko Inagi
    • Organizer
      Annual Conference of the Korean Society for Gerontology (The 12th Korea-Japan joint symposia)
    • Place of Presentation
      Osong, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] glyoxalase-1による糖化反応の抑制とNO生体利用効率の改善2012

    • Author(s)
      城愛理、他
    • Organizer
      第12回日本NO学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Endoplasmic Reticulum Stress and kidney disease2012

    • Author(s)
      Reiko Inagi
    • Organizer
      INSERM seminar
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Glyoxalase I retards renal senescence - Glycative stress as a mediator of renal senescence-2012

    • Author(s)
      Reiko Inagi
    • Organizer
      The 34th Japan Society for Biomedical Gerontology symposium (Molecular and Cellular biology of Aging)
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] miR-205 modulates cellular senescence state caused by oxidative and endoplasmic reticulum (ER) stresses in renal tubular cells2012

    • Author(s)
      Shiyo Muratsu, et al.
    • Organizer
      Keystone Symposium: Aging and Diseases of Aging (S2)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glyoxlase I ameliorates Age-related endothelial dysfunction2012

    • Author(s)
      Airi Jo, et al.
    • Organizer
      Keystone Symposium: Aging and Diseases of Aging (S2)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of a Novel Hypoxia-Inducible Factor 1 (HIF-1) Regulator, CCAAT/Enhancer-Binding Protein Delta (CEBPD) in Kidney Disease2012

    • Author(s)
      Junna Yamaguchi, et al.
    • Organizer
      Annual meeting of Am Soc Nephrol (Kidney week 2012)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glyoxalase I Ameliorates Age-Related Endothelial Dysfunction2012

    • Author(s)
      Airi Jo, et al.
    • Organizer
      Annual meeting of Am Soc Nephrol (Kidney week 2012)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Downregulation of miR-205 Modulates Cell Susceptibility to Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells2012

    • Author(s)
      Shiyo Muratsu, et al.
    • Organizer
      Annual meeting of Am Soc Nephrol (Kidney week 2012)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Endoplasmic Reticulum (ER) Stress Signal Impairs Erythropoietin Production: A Role for ATF42012

    • Author(s)
      Chih-Kang Chiang, et al.
    • Organizer
      Annual meeting of Am Soc Nephrol (Kidney week 2012)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification and Characterization of a Novel HIF-1 Target that regulates Cytokinesis as a Defensive Mechanism against Polyploidy2012

    • Author(s)
      Kumi Shoji, et al.
    • Organizer
      Annual meeting of Am Soc Nephrol (Kidney week 2012)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 虚血および炎症性腎疾患における新規HIF-1制御遺伝子としてのCEBPDの同定2012

    • Author(s)
      山口純奈 他
    • Organizer
      第3回腎不全研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glyoxalase 1によるeNOSの活性調節を介した血管内皮機能障害の軽減と血管老化の進行抑制2012

    • Author(s)
      城愛理 他
    • Organizer
      第3回腎不全研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glyoxalase 1による血管内皮の糖化抑制を介した内皮機能障害の軽減と血管老化の進行抑制2012

    • Author(s)
      城愛理 他
    • Organizer
      第22回日本メイラード学会年会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Endoplasmic reticulum (ER) stress impairs erythropoietin (EPO) production : a role for ER stress signal transcription factor, ATF42012

    • Author(s)
      Chiang, et al.
    • Organizer
      Keystone Symposia 2012
    • Place of Presentation
      USA (Bonston)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小胞体ストレスと腎性貧血.2011

    • Author(s)
      稲城玲子
    • Organizer
      協和発酵キリン腎臓シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 小胞体ストレスと腎性貧血2011

    • Author(s)
      稲城玲子
    • Organizer
      協和発酵キリン腎臓シンポジウム
    • Place of Presentation
      東京(招待)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Derangement of Oxygen Sensing for Erythropoietin (EPO) Production by Unfolded Protein Response (UPR)2011

    • Author(s)
      Inagi, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      U.S.A.(Philadelphia)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification & Characterization of a Novel Oncogenic HIF-1 Target In volved in Renal Cell Carcinoma2011

    • Author(s)
      Shoji, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      U.S.A.(Philadelphia)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Renal Ischemia Reperfusion Injury Promotes Mid-Term Tubular Senescenee2011

    • Author(s)
      Ikeda, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      U.S.A.(Philadelphia)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小胞体ストレスとARB.2011

    • Author(s)
      稲城玲子
    • Organizer
      ARBのエビデンスを考える会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 小胞体ストレスとAEB2011

    • Author(s)
      稲城玲子
    • Organizer
      ARBのエビデンスを考える会
    • Place of Presentation
      東京(招待)
    • Year and Date
      2011-11-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Endoplasmicreticulum: the master regulator of stress responses in kidney disease.2011

    • Author(s)
      Reiko Inagi
    • Organizer
      The20th anniversary symposium of the Korean Society of Life Science
    • Place of Presentation
      Busan, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Endoplasmic reticulum stress in glomerulonephritis.2011

    • Author(s)
      Reiko Inagi (Invited)
    • Organizer
      Annual meeting of World congress of Nephrology (WCN2011)
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Final Research Report
  • [Presentation] Endoplasmic reticulum stress in glomerulonephritis2011

    • Author(s)
      Inagi
    • Organizer
      Annual meeting of World congress of Nephrology (WCN2011)
    • Place of Presentation
      Canada (Vancouver)(Invited)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Endoplasmic reticulum : the master regulator of stress responses in kidney disease2011

    • Author(s)
      Inagi
    • Organizer
      The 20^<th> anniversary symposium of the Korean Society of Life Science
    • Place of Presentation
      Korea (Busan)(Invited)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Overwhelming Endoplasmic Reticulum Stress Disturbs Erythropoietin Gene Expression2011

    • Author(s)
      Chiang, et al.
    • Organizer
      Annual meeting of World congress of Nephrology (WCN2011)
    • Place of Presentation
      Canada (Vancouver)
    • Related Report
      2011 Annual Research Report
  • [Presentation] microRNA profiles of tubular cells under hypoxia-reoxigenation and ER stress.2011

    • Author(s)
      Muratsu S, et al.
    • Organizer
      Keystone Symposia 2011 microRNAs and human disease(J6)
    • Place of Presentation
      Banff UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endoplasmic Reticulum Stress and Kidney Disease.2010

    • Author(s)
      稲城玲子
    • Organizer
      南大阪腎臓セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Endoplasmic Reticulum Stress and Kidney Disease2010

    • Author(s)
      稲城玲子
    • Organizer
      南大阪腎臓セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endoplasmic reticulum stress as a progression factor for kidney disease.2010

    • Author(s)
      Reiko Inagi (Invited)
    • Organizer
      Seminar in Kyungpook National University
    • Place of Presentation
      Daegue, Korea
    • Year and Date
      2010-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Endoplasmic reticulum stress as a progression factor for kidney disease2010

    • Author(s)
      Reiko Inagi
    • Organizer
      Seminar in Kyungpook National Univeriity
    • Place of Presentation
      Daegue KOREA
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endoplasmic reticulum stress as a progression factor for kidney disease.2010

    • Author(s)
      Reiko Inagi
    • Organizer
      The Korean Society for Microbiology and Biotechnology Annual Meeting & International Symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] The evaluation of renal senescence and its retardation by the reduction of carbonyl stress.2010

    • Author(s)
      Yoichiro Ikeda, et al.
    • Organizer
      ISN Nexus
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] microRNA profiles of tubular cells under hypoxia and ER stress.2010

    • Author(s)
      村津四葉, 他
    • Organizer
      日本腎臓学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規グロブリン蛋白Cytoglobinは酸化ストレスの軽減により腎尿細管間質の線維化を軽減する2010

    • Author(s)
      三村維真理, 他
    • Organizer
      日本腎臓学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glyoxalase 1(GLO1)の腎臓および大動脈に対する老化抑制作用2010

    • Author(s)
      池田洋一郎, 他
    • Organizer
      日本腎臓学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endoplasmic reticulum stress as a progression factor for kidney disease2010

    • Author(s)
      Reiko Inagi
    • Organizer
      The Korean Society for Microbiology and Biotechnology Annual Meeting & International Symposium
    • Place of Presentation
      Seoul KOREA
    • Related Report
      2010 Annual Research Report
  • [Presentation] MicroRNA Profiles of Tubular Cells under Hypoxia-Reoxygenation and Endoulasxrdc Reticulum Stress2010

    • Author(s)
      Shiyo Muratsu, et al.
    • Organizer
      43^<rd> annual meeting of ASN
    • Place of Presentation
      Denver USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elucidation of the Anti-Fibrotic Mechanism of a Novel HIF-Regulated Globin, Cvtoglobin, with Molecular Genetics2010

    • Author(s)
      Imari Mimura, et al.
    • Organizer
      43^<rd> annual meeting of ASN
    • Place of Presentation
      Denver USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glyoxalase I Prevent Age-Related Aortic Medial Thickening by Reducing TGF-β and CTGF Signals Independent of Blood Pressure2010

    • Author(s)
      Yoichiro Ikeda, et al.
    • Organizer
      43^<rd> annual meeting of ASN
    • Place of Presentation
      Denver USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endoplasmic Reticulum Stress Disturbs Erythropoietin Gene Expression in a HIF-Dependent Manner2010

    • Author(s)
      Chih-Kang Chiang, et al.
    • Organizer
      43^<rd> annual meeting of ASN
    • Place of Presentation
      Denver USA
    • Related Report
      2010 Annual Research Report
  • [Book] アンチ・エイジング医学:老化を促進する危険因子としての糖化ストレス2012

    • Author(s)
      稲城玲子
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] AGEsと老化-糖化制御からみたウェルエイジングー2012

    • Author(s)
      城愛理、稲城玲子、南学正臣
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] アンチ・エイジング医学:老化を促進する危険因子としての糖化ストレス2012

    • Author(s)
      稲城玲子
    • Total Pages
      169
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] AGEsと老化 ―糖化制御からみたウェルエイジングー2012

    • Author(s)
      城 愛理 他
    • Total Pages
      278
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] Etiology and Pathogenesis .2011

    • Author(s)
      Inagi R.
    • Total Pages
      276
    • Publisher
      In Tech, An Update on Glomerulopathies - Volume I.
    • Related Report
      2012 Final Research Report
  • [Book] 内分泌・糖尿病・代謝内科2011

    • Author(s)
      稲城玲子、南学正臣
    • Total Pages
      160
    • Publisher
      科学評論社
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Book] An Update on Glomerulopathies-Volume I. Etiology and Pathogenesis2011

    • Author(s)
      Inagi
    • Total Pages
      276
    • Publisher
      In Tech
    • Related Report
      2011 Annual Research Report
  • [Book] Endoplasmic reticulum stress as a target of therapy against oxidative stress and hypoxia in Studies on Renal Disorders.2010

    • Author(s)
      Inagi R.
    • Total Pages
      783
    • Publisher
      Humana Press
    • Related Report
      2012 Final Research Report
  • [Book] The role of glyoxalase system in renal hypoxia in Oxygen transport to tissue XXXI.2010

    • Author(s)
      Inagi R.
    • Total Pages
      552
    • Publisher
      Springer
    • Related Report
      2012 Final Research Report
  • [Book] Studies on Renal Disorders2010

    • Author(s)
      Reiko Inagi
    • Total Pages
      783
    • Publisher
      Endoplasmic reticulum stress as a target of therapy against oxidative stress and hypoxia
    • Related Report
      2010 Annual Research Report
  • [Book] Oxygen transport to tissue XXXI2010

    • Author(s)
      Reiko Inagi, et.al.
    • Total Pages
      552
    • Publisher
      The role of glyoxalase system in renal hypoxia
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.todai-jinnai.com/kenkyu/g_nephrology/g01_nephrology

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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