| Project/Area Number |
22590881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tadashi 新潟大学, 医歯学系, 教授 (30092737)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 腎臓学 / 尿バイオマーカー / 尿プロテオーム / 分析化学 / 質量分析 / 多項目同時定量 / AKIバイオマーカー / 尿バイオマーカーパネル化 |
|---|
| Research Abstract |
A Proteomic analysis of normal urine proteome and seeking of urinary proteins originated from the glomerulus, we found biomarker candidates of tubular injury (NGAL, L-FABP, KIM-1, Megalin) and glomerulus injury (Podocalyxin, SHPS-1, Crumbs-like protein 2). We now constructed SRM transition conditions for multiplexed assay of these biomarkers using TripleQ-mass spectrometer.
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