Therapeutic approaches of AKI by adipose-derived mesenchymal cells, and urinary biomarker search in AKI
| Project/Area Number |
22590883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WADA Takashi 金沢大学, 医学系, 教授 (40334784)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | バイオマーカー / 虚血腎障害 / 脂肪由来間葉系細胞 / 質量分析計 / IP-10 / 再生 / サイトカイン / ケモカイン |
|---|
| Research Abstract |
everal urinary biomarker candidates of acute kidney injury were detected by mass spectrometry. We also detected several urinary biomarker candidates of acute kidney injury by multiple cytokine/chemokine detection methods. In this study, we explored the effects of adipose-derived mesenchymal cells on a mouse model of AKI. The effects of adipose-derived mesenchymal cells were evaluated in AKI mouse model. A lthough, administered adipose-derived mesenchymal cells were tend to home into lung, repeated administration of adipose-derived mesenchymal cells reduced acute tubular necrosis and interstitial macrophage infiltration.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury2012
Author(s)
Furuichi K, Kokubo S, Hara A, Imamura R, Wang Q, Kitajima S, Toyama T, Okumura T, Matsushima K, Suda T, Mukaida N, Kaneko S, Wada T
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Journal Title
Nephron Extra
Volume: 2
Issue: 1
Pages: 27-38
DOI
Related Report
Peer Reviewed
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[Journal Article] Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice2012
Author(s)
Ito, M., Sugihara, K., Asaka, T., Toyama, T., Yo sh ih ar a, T., Furuichi, K., Wada, T. and Asano, M.
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Journal Title
PLoS ONE
Volume: 7
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed
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