Evaluation of gene-environment interaction in development of chronic kidney disease and cardio-vascular disease

• Project/Area Number: 22590888
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: HAYASHI Mutsuharu 名古屋大学, 医学系研究科, 寄附講座講師 (70426500)
• Co-Investigator(Kenkyū-buntansha): IMAI Enyu 名古屋大学, 医学系研究科, 特任准教授 (00223305) ; YASUDA Yoshinari 名古屋大学, 医学系研究科, 寄附講座准教授 (60432259) ; HONDA Hiroyuki 名古屋大学, 工学系研究科, 教授 (70209328)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 腎臓学 / 一塩基多形(SNP) / 環境因子 / メタボリック症候群 / 糖尿病(DM) / 慢性腎臓病(CKD) / CKD / SNP / バイオインフォマティクス / CVD / 遺伝子環境相互作用

Research Abstract

We acquired the company medical examination data for the past several years more than 50,000, medical careinformation including the environmental parameter (smoking, meal taste, exercise customs) at the same time to perform DNA extraction, the SNPs analysis of approximately 1,200 people with an agreement, the cooperation of a company and the employee. We developed an SNP tip for metabolic syndrome and diabetes and extracted disease group and a control group and performed SNP analysis. Using bioinformatics software of the new development, I performed SNP and a blood test, combination of environmental parameter analysis and identified a new combination about a risk about metabolic syndrome, diabetes onset and progression.

Research Products

• [Journal Article] Combinational risk factors of metabolic syndrome identified by fuzzy neural networkanalysis of health-check data (2012)
  • Author(s): Yasunori Ushida, Ryuji Kato, Kosuke Niwa, Daisuke Tanimura, Hideo Izawa, Kenji Yasui, Tomokazu TakaseYasuko Yoshida, Mitsuo Kawase, Tsutomu Yoshida, Toyoaki Murohara and Hiroyuki Honda
  • Journal Title: BMC Medical Informatics and Decision Making Volume: 12 Pages: 80-80
  • Peer Reviewed
• [Journal Article] Effects of carperitide on contrast-induced acute kidney injury with a minimum volume of contrast in chronic kidney disease patients (2012)
  • Author(s): Okumura N, Hayashi M, Imai E, Ishii H, Yoshikawa D, Yasuda Y, Goto M, Matsuo S, Oiso Y, Murohara T
  • Journal Title: Nephron Extra Volume: 2(1) Pages: 303-10
  • Peer Reviewed
• [Journal Article] Combinational risk factors of metabolic syndrome identified by fuzzy neural network analysis of health-check data (2012)
  • Author(s): Yasunori Ushida
  • Journal Title: BMC Medical Informatics and Decision Making Volume: 12:80 Issue: 1
  • DOI: 10.1186/1472-6947-12-80
  • Peer Reviewed
• [Journal Article] Effects of carperitide on contrast-induced acute kidney injury with a minimum volume of contrast in chronic kidney disease patients. (2012)
  • Author(s): Naoki Okumura
  • Journal Title: Nephron Extra Volume: Jan;2(1) Issue: 1 Pages: 303-310
  • DOI: 10.1159/000345483
  • Peer Reviewed
• [Journal Article] Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction. (2011)
  • Author(s): Hayashi M, Takeshita K, Inden Y, Ishii H, Cheng XW, Yamamoto K, Murohara T
  • Journal Title: Thromb Res. Dec Volume: 128(6)
  • Peer Reviewed
• [Journal Article] Association of adiponectin with carotid arteriosclerosis in predialysis chronic kidney disease. (2011)
  • Author(s): Hayashi M, Shibata R, Takahashi H, Ishii H, Aoyama T, Kasuga H, Yamada S, Ohashi K, Maruyama S, Matsuo S, Ouchi N, Murohara T, Toriyama T.
  • Journal Title: Am J Nephrol Volume: 34(3) Pages: 249-55
  • Peer Reviewed
• [Journal Article] Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease (2011)
  • Author(s): Imai E, Yasuda Y, Horio M, Shibata K, Kato S, Mizutani Y, Imai J, Hayashi M, Kamiya H, Oiso Y, Murohara T, Maruyama S, Matsuo S
  • Journal Title: Clin Exp Nephrol. Dec Volume: 15(6) Pages: 861-7
  • NAID: 10030341755
  • Peer Reviewed
• [Journal Article] 長期追跡健康診断データにおける遺伝・環境要因を用いた生活習慣病リスク決定法 (2010)
  • Author(s): Yasunori Ushida, Ryuji Kato, Daisuke Tanimura, Hideo Izawa, Kenji Yasui, Tomokazu Takase, Yasuko Yoshida, Mitsuo Kawase, Tsutomu Yoshida, Toyoaki Murohara, and Hiroyuki Honda
  • Journal Title: 生物工学会誌 Volume: 88(11) Pages: 562-569
  • NAID: 110007989522
  • Peer Reviewed
• [Presentation] Impact of Indoxyl Sulfate on the Progression of Endothelial Dysfunction and Atherosclerosis in Chronic Kidney Disease Patients (2013)
  • Author(s): Mutsuharu Hayashi, Hideki Ishii, Daiji Yoshikawa, Akihiro Hirashiki, Takahiro Okumura, Toyoaki Murohara
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-16
• [Presentation] Brain Natriuretic Peptide as a Nobel Marker of Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction (2013)
  • Author(s): Mutsuharu Hayashi, Hideki Ishii, Daiji Yoshikawa, Akihiro Hirashiki, Takahiro Okumura, Toyoaki Murohara
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-16
• [Presentation] Brain Natriuretic Peptide as a Nobel Marker of Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction (2013)
  • Author(s): Mutsuharu Hayashi
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Impact of Indoxyl Sulfate on the Progression of Endothelial Dysfunction and Atherosclerosis in Chronic Kidney Disease Patients (2013)
  • Author(s): Mutsuharu Hayashi
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Brain Natriuretic Peptide as a Novel Marker of Salt-sensitivity in Chronic Kidney Disease Patients without Cardiac Dysfunction (2012)
  • Author(s): Mutsuharu Hayashi, Yoshinari Yasuda, Hideki Ishii, Daiji Yoshikawa, Toyoaki Murohara
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angels,USA
  • Year and Date: 2012-11-06
• [Presentation] CKD(慢性腎臓病)患者におけるレニン・アンギオテンシン・アルドステロン(RAS)系とBNPの関係 (2012)
  • Author(s): 林睦晴 安田宜成 後藤資実 石井秀樹 松尾清一 大磯ユタカ 室原豊明
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] CKD(慢性腎臓病)患者におけるレニン・アンギオテンシン・アルドステロン(RAS)系とBNPの関係 (2012)
  • Author(s): Mutsuharu Hayashi
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ウェスティン名古屋キャッスル（名古屋）