Analysis of flora specific to tonsils with IgA nephropathy patients
Project/Area Number |
22590891
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
|
Research Institution | Hyogo Medical University (2012) Osaka University (2010-2011) |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | IgA腎症 / 扁桃 / 細菌叢 / Treponema sp. / Haemophilus segnis / Campylobacter rectus / 内科 / 細菌 / 微生物 / DGGE法 / 慢性腎不全 / 嫌気性菌 / 歯周病菌 / Treponema sp |
Research Abstract |
The comprehensive analysis of flora specific to tonsils with IgA nephropathy patients has been performed, and Treponema sp., Haemophilus segnis, Campylobacter rectus are identified as the bacteria specific to tonsils with IgA nephropathy patients. There was strong relationship between these bacteria and the treatment of tonsillectomy and steroid pulse, therefore the detection of these bacteria might predict the response of these therapies.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Age and prediction of remission and relapse of proteinuria and corticosteroid-related adverse events in adult-onsetminimal-change disease: a retrospective cohort study.2013
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Tomida K, Hayashi T, Izumi M, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
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Journal Title
Clin Exp Nephrol.
Volume: 20.
Issue: 6
Pages: 839-847
DOI
Related Report
Peer Reviewed
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[Journal Article] Age and prediction of remission and relapse of proteinuria and corticosteroid-related adverse events in adult-onset minimal-change disease: a retrospective cohort study.2013
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Tomida K, Hayashi T, Izumi M, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
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Journal Title
Clin Exp Nephrol.
Volume: Mar
Related Report
Peer Reviewed
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[Journal Article] Themitochondrial protein frataxin is downregulated in hemodialysispatients.2012
Author(s)
Hasuike Y, Nagai T, Yorifuji S, Tanaka S, Matsumoto A, Yahiro M, Kaibe S, Kida A, Tokuyama M, Nagasawa Y, Otaki Y, Kuragano T, Nakanishi T
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Journal Title
Clin Exp Nephrol.
Volume: 17
Issue: 3
Pages: 424-430
DOI
Related Report
Peer Reviewed
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[Journal Article] A candidate gene approach to genetic contributors tothe development of IgA nephropathy.2012
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Katakami N, Ohtoshi K, Hayaishi-Okano R, Yamasaki Y, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y
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Journal Title
Nephrol Dial Transplant.
Volume: 27(3)
Issue: 3
Pages: 1020-30
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum hepcidin-25 levels and anemia innon-dialysis chronic kidney disease patients: a cross-sectional study2012
Author(s)
Uehata T, Tomosugi N, Shoji T,Sakaguchi Y, Suzuki A, Kaneko T, OkadaN, Yamamoto R, Nagasawa Y, Kato K, Isaka Y, Rakugi H, Tsubakihara Y.
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Journal Title
Nephrol Dial Transplant
Volume: 27(3)
Issue: 3
Pages: 1076-83
DOI
Related Report
Peer Reviewed
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[Journal Article] Towards developing new strategies to reduce the adverse side-effects of nonsteroidalanti-inflammatory drugs.2012
Author(s)
Kawada N, Moriyama T, Kitamura H, Yamamoto R, Furumatsu Y, Matsui I, Takabatake Y, Nagasawa Y, Imai E, Wilcox CS, Rakugi H, Isaka Y.
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Journal Title
Clin ExpNephrol.
Volume: 16(1)
Issue: 1
Pages: 25-9
DOI
Related Report
Peer Reviewed
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[Journal Article] The mitochondrial protein frataxin is downregulated in hemodialysis patients.2012
Author(s)
Hasuike Y, Nagai T, Yorifuji S, Tanaka S, Matsumoto A, Yahiro M, Kaibe S, Kida A, Tokuyama M, Nagasawa Y, Otaki Y, Kuragano T, Nakanishi T.
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Journal Title
Clin Exp Nephrol
Volume: Nov
NAID
Related Report
Peer Reviewed
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[Journal Article] Microarray analysis of tonsils of IgA nephropathy patients.2011
Author(s)
Iwatani H, Iio K, Nagasawa Y, Yamamoto R, Horii A, Okuzaki D, Inohara H, Nojima H, Imai E, Rakugi H, Isaka Y.
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Journal Title
Adv Otorhinolaryngol.
Volume: 72
Pages: 75-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease.2011
Author(s)
Kimura T, Kitamura H, Inoue K, Kawada N, Matsui I, Nagasawa Y, Obi Y, Shinzawa M, Sakata Y, Hamono T, Rakugi H, Isaka Y.
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Journal Title
Clin Exp Nephrol.
Volume: 15(6)
Issue: 6
Pages: 854-60
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy2011
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Shoji T, Obi Y, Namba T, Kitamura H, Kaneko T, Okada N, Iwatani H, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
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Journal Title
Clin Exp Nephrol
Volume: 11(Epub)
NAID
Related Report
Peer Reviewed
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[Journal Article] Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs2011
Author(s)
Kawada N, Moriyama T, Kitamura H, Yamamoto R, Furumatsu Y, Matsui I, Takabatake Y, Nagasawa Y, Imai E, Wilcox CS, Rakugi H, Isaka Y
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Journal Title
Clin Exp Nephrol
Volume: 11(Epub)
NAID
Related Report
Peer Reviewed
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[Journal Article] Self-reported Sleep Duration and Prediction of Proteinuria : A Retrospective Cohort Study2011
Author(s)
Yamamoto R, Nagasawa Y, Iwatani H, Shinzawa M, Obi Y, Teranishi J, Ishigami T, Yamauchi-Takihara K, Nishida M, Rakugi H, Isaka Y, Moriyama T
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Journal Title
Am J Kidney Dis
Volume: Oct(Epub)
Related Report
Peer Reviewed
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[Journal Article] Microarray analysis of tonsils of IgA nephropathy patients2011
Author(s)
Iwatani H, Iio K, Nagasawa Y, Yamamoto R, Horii A, Okuzaki D, Inohara H, Nojima H, Imai E, Rakugi H, Isaka Y.
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Journal Title
Adv Otorhinolaryngol
Volume: 72
Pages: 75-8
Related Report
Peer Reviewed
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[Journal Article] Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease2011
Author(s)
Kimura T, Kitamura H, Inoue K, Kawada N, Matsui I, Nagasawa Y, Obi Y, Shinzawa M, Sakata Y, Hamono T, Rakugi H, Isaka Y
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Journal Title
Clin Exp Nephrol
Volume: Aug(Epub)
NAID
Related Report
Peer Reviewed
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[Journal Article] Serum hepcidin-25 levels and anemia in non-dialysis chronic kidney disease patients : a cross-sectional study2011
Author(s)
Uehata T, Tomosugi N, Shoji T, Sakaguchi Y, Suzuki A, Kaneko T, Okada N, Yamamoto R, Nagasawa Y, Kato K, Isaka Y, Rakugi H, Tsubakihara Y
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Journal Title
Nephrol Dial Transplant
Volume: Jul(Epub)
Related Report
Peer Reviewed
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[Journal Article] A candidate gene approach to genetic contributors to the development of IgA nephropathy2011
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Katakami N, Ohtoshi K, Hayaishi-Okano R, Yamasaki Y, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y
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Journal Title
Nephrol Dial Transplant
Volume: Jul(Epub)
Related Report
Peer Reviewed
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[Journal Article] Impact of age and overt proteinuria on outcomes of stage 3-5 chronic kidney disease in a referred cohort2010
Author(s)
Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamura H, Imai E, Rakugi H,Isaka Y, Hayashi T.
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Journal Title
Clin J Am Soc Nephrol
Volume: 5(9)
Issue: 9
Pages: 1558-65
DOI
Related Report
Peer Reviewed
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[Journal Article] Urinary Type IV Collagen in Nondiabetic Kidney Disease.2010
Author(s)
Furumatsu Y, Nagasawa Y, Shoji T, Yamamoto R, Iio K, Matsui I, Takabatake Y, Kaimori JY, Iwatani H, Kaneko T, Tsubakihara Y, Imai E, Isaka Y, Rakugi H.
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Journal Title
Nephron Clin Pract.
Volume: 12;11
Issue: 6
Pages: 160-166
DOI
Related Report
Peer Reviewed
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[Journal Article] Rakugi H. Cigarette Smoking and Progression of IgA Nephropathy Am2010
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Moriyama T, Horio M, Yamauchii A, Tsubakihara Y, Imai E, Isaka Y
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Journal Title
J Kidney Dis
Volume: 56(2)
Issue: 2
Pages: 313-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Cigarette Smoking and Progression of IgA Nephropathy.2010
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Moriyama T, Horio M, Yamauchii A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H.
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Journal Title
Am J Kidney Dis
Volume: 56
Pages: 313-324
Related Report
Peer Reviewed
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[Journal Article] Impact of age and overt proteinuria on outcomes of stage 3-5 chronic kidney disease in a referred cohort2010
Author(s)
Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamwa H, Imai E, Rakugi H, Isaka Y, Hayashi T.
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Journal Title
Clin J Am Soc Nephrol
Volume: 5
Pages: 1558-1565
Related Report
Peer Reviewed
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[Presentation] Intravenous methylprednisolone therapy acceleratedcomplete remission of proteinuria in adult patients with minimal change nephrotic syndrome.2012
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Niihata K, Tomida K, Izumi M, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
Organizer
American Society of Nephrology Kidney Week Annual Meeting
Place of Presentation
San Diego, USA
Year and Date
2012-11-02
Related Report
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[Presentation] Methylprednisolone pulse therapy accelerated complete remission of proteinuria in adult-onset minimal change nephrotic syndrome patients.2012
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Niihata K, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
Organizer
XLVIIII ERA-EDTA congress
Place of Presentation
Paris, France
Year and Date
2012-05-25
Related Report
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[Presentation] Intravenous methylprednisolone therapy accelerated complete remission of proteinuria in adult patients with minimal change nephrotic syndrome.2012
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Niihata K, Tomida K, Izumi M, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
Organizer
American Society of Nephrology Kidney Week 2012 Annual Meeting
Place of Presentation
San Diego/USA
Related Report
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[Presentation] Association between liver enzymes and proteinuria stratified on drinking status: a nationwide cross-sectional study.2012
Author(s)
Ishigami T, Yamamoto R, Nagasawa Y, Isaka Y, Konta T, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Watanabe T.
Organizer
XLVIIII ERA-EDTA congress
Place of Presentation
Paris/France
Related Report
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[Presentation] ACE Insertion/Deletion (I/D) polymorphism predicted renoprotective effectiveness of renin-angiotensin system (RAS) blockade in patients with IgA nephropathy.2012
Author(s)
Teranishi J, Yamamoto R, Nagasawa Y, Shoji Y, Iwatani H, Okada N, Moriyama T, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y.
Organizer
XLVIIII ERA-EDTA congress
Place of Presentation
Paris/France
Related Report
-
[Presentation] Methylprednisolone pulse therapy accelerated complete remission of proteinuria in adult-onset minimal change nephrotic syndrome patients.2012
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Oseto S, Mori D, Niihata K, Fukunaga M, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
Organizer
XLVIIII ERA-EDTA congress
Place of Presentation
Paris/France
Related Report
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[Presentation] Quantitative Analysis of O-Glycosylation of IgA Hinge Portion (HP) in IgA Nephropathy (IgAN) Patients and Its Responsiveness to the Therapy of Tonsillectomy Combined with Corticosteroid IV (TLX+S).2011
Author(s)
Iwatani H, Nagasawa Y, Inoue T, Ueda Y,Yamamoto R, Shinzawa M, Obi Y, Teranishi J, Ishigami T, Iijima H, Wada Y, Rakugi H, Isaka Y.
Organizer
American Society of Nephrology
Place of Presentation
Philadelphia,USA
Year and Date
2011-11-12
Related Report
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[Presentation] ACE Insertion/Deletion (I/D) Polymorphism Predicts RenoprotectiveEffectiveness of Renin-Angiotensin System Brockade (RASb), along with Progression, in IgA Nephropathy (IgAN).2011
Author(s)
Teranishi J, Yamamoto R, Nagasawa Y, Shoji T, Uehata T, Okada N, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
Organizer
American Society of Nephrology
Place of Presentation
Philadelphia,USA
Year and Date
2011-11-11
Related Report
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[Presentation] A Candidate Gene Approach to Genetic Contributors to Development of IgA Nephropathy.2011
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, KatakamiN, Ohtoshi K, Hayaishi-Okano R, Yamasaki Y, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y.
Organizer
American Society of Nephrology
Place of Presentation
Philadelphia,USA
Year and Date
2011-11-11
Related Report
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[Presentation] A Candidate Gene Approach to Genetic Contributors to Development of IgA Nephropathy2011
Author(s)
Iwatani H, Nagasawa Y, Inoue T, Ueda Y, Yamamoto R, Shinzawa M, Obi Y, Teranishi J, Ishigami T, Iijima H, Wada Y, Rakugi H, Isaka Y
Organizer
American Society of Nephrology
Place of Presentation
Philadelphia, U.S.A.
Year and Date
2011-11-11
Related Report
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[Presentation] ACE Insertion/Deletion (I/D) Polymorphism Predicts Renoprotective Effectiveness of Renin-Angiotensin System Brockade (RASb), along with Progression, in IgA Nephropathy (IgAN)2011
Author(s)
Teranishi J, Yaraamoto R, Nagasawa N, Shoji T, Uehata T, Okada N, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y
Organizer
American Society of Nephrology
Place of Presentation
Philadelphia, U.S.A.
Year and Date
2011-11-11
Related Report
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[Presentation] A candidate gene approach to genetic contributors to development of IgA nephropathy2011
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Katakami N, Ohtoshi K, Hayaishi-Okano R, Yamasaki Y, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y
Organizer
XLVIII European Renal Assocation-European Dialysis and Transplant Association Congress
Place of Presentation
Prague, Czech Republic
Year and Date
2011-06-24
Related Report
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[Presentation] BACTERIA SPECIFIC TO TONSIL IN IgA NEPHROPATHY PATIENTS PREDICTS THE REMISSION BY THE TREATMENT OF TONSILLECTOMY AND CORTICOSTEROID PULSE2011
Author(s)
Nagasawa Y, Iio K, Fukuda S, Date Y, Iwatani H, Yamamoto R, Horii A, Inohara H, Imai E, Ohno H, Rakugi H, Isaka
Organizer
XLVIII European Renal Assocation-European Dialysis and Transplant Association Congress
Place of Presentation
Prague, Czech Republic
Year and Date
2011-06-23
Related Report
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[Presentation] Cigarette Smoking Abrogates a Renoprotective Effect of Renin-Angiotensin-Aldosterone System (RAAS) Blockade in Patients with IgA Nephropathy2010
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Kawada N,Horio M, Moriyama T, Yamauchi A, Tsubakihara Y, Rakugi H, Isaka Y.
Organizer
American Society of Nephrology
Place of Presentation
Denver,USA
Year and Date
2010-11-18
Related Report
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[Presentation] Combination of Tonsillectomy and Corticosteroid Suppressed Recurrence of Urinary Protein and Occult Blood in Patients with IgA Nephropathy,Compared with Corticosteroid Alone2010
Author(s)
Takahashi A, Yamamoto R, Nagasawa Y, Iwatani H, Iio K, Shinzawa M, Horii A,Yamauchi A, Rakugi H, Isaka Y.
Organizer
AmericanSociety of Nephrology
Place of Presentation
Denver,USA
Year and Date
2010-11-18
Related Report
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[Presentation] GenePolymorphisms Contributing to Hypertensionin IgA Nephropathy2010
Author(s)
Shinzawa M, Yamamoto R, Nagasawa Y, Shoji T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y.
Organizer
American Society ofNephrology
Place of Presentation
Denver,USA
Year and Date
2010-11-17
Related Report
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[Presentation] ACE Insertion/Deletion (I/D) polymorphism predicted renoprotective effectiveness of renin-angiotensin system (RAS) blockade in patients with IgA nephropathy.2010
Author(s)
Teranishi J, Yamamoto R, Nagasawa Y, ShojiY, Iwatani H, Okada N, Moriyama T, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y.
Organizer
XLVIIII ERA-EDTA congress
Place of Presentation
Paris, France
Year and Date
2010-05-26
Related Report