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Association of serum cystatin C with the risk of the development of cardiovascular disease in a general Japanese population: the Hisayama Study

Research Project

Project/Area Number 22590892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKyushu University

Principal Investigator

NINOMIYA Toshiharu  九州大学, 大学病院, 助教 (30571765)

Co-Investigator(Kenkyū-buntansha) KIYOHARA Yutaka  九州大学, 医学研究院, 教授 (80161602)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腎臓学 / 心臓病 / 認知症 / シスタチンC / アルブミン尿 / 糸球体濾過値 / 動脈硬化 / 心血管病 / 総死亡 / 系球体濾過値
Research Abstract

The aims of this project were to investigate the association of sCysC on the risk of atherosclerotic disease among 3,328 community-dwelling Japanese individuals aged 40 years or older. First, we investigated the relationship between sCysC and prevalence of peripheral arterial disease (PAD) defined as ankle-brachial index <0.9. As a result, the unadjusted prevalence of PAD increased linearly with elevating sCysC levels. However, there was no evidence of the significant relationship in the multivariate-adjusted analysis. Next, we estimated the association of sCysC and the cardiovascular risk in an average 7.1-year follow-up study conducted in the above population. Higher sCysC levels were associated significantly with the unadjusted incidence of cardiovascular disease, but this significant association disappeared after adjusting confounding factors.Finally, we assessed the relationship between estimated glomerular filtration rate with sCysC (eGFR-CysC) and the risk of incident cardiovascular disease and all-cause mortalityin the above follow-up data. Lower eGFR-CysC was a risk factor for the incident cardiovascular disease and all-cause mortality.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study2012

    • Author(s)
      Hirakawa Y, Ninomiya T, Mukai N, Doi Y, Hata J, Fukuhara M, Iwase M, Kitazono T, Kiyohara Y
    • Journal Title

      Am J Epidemiol

      Volume: 176 Pages: 856-864

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-reported dietary intake of potassium and magnesium and risk of dementia in the Japanese: the Hisayama Study2012

    • Author(s)
      Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y
    • Journal Title

      J Am Geriatr Soc

      Volume: 60 Pages: 1515-1520

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study2012

    • Author(s)
      Ozawa M, et al.
    • Journal Title

      J Am Geriatr Soc

      Volume: 60 Pages: 1515-1520

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Albuminuria as a risk factor for peripheral arterial disease in a general population: the Hisayama Study2011

    • Author(s)
      Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y
    • Journal Title

      J Atheroscler Thromb

      Volume: 18 Pages: 705-712

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Albuminuria as a Risk Factor for Peripheral Arterial Disease in a General Population2011

    • Author(s)
      Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 18 Issue: 8 Pages: 705-712

    • DOI

      10.5551/jat.7682

    • NAID

      130004444538

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Association of albuminuria with peripheral arterial disease in a general Japanese population : the Hisayama study2010

    • Author(s)
      Tomoko Usui, Toshiharu Ninomiya, Yasufumi Doi, M.D, et al.
    • Organizer
      The 43rd Annual Meeting and Scientific Exposition for the American Society of Nephrology
    • Place of Presentation
      Colorado Convention Center Denver, CO, USA
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of albuminuria with peripheral arterial disease in a general Japanese population: the Hisayama study2010

    • Author(s)
      Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y
    • Organizer
      The 43rd Annual Meeting and Scientific Exposition for the American Society of Nephrology
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-10-21
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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