| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Interferon regulatory factor 5 (IRF5) is a transcription factor and considered to be involved in the development of systemic lupus erythematosus. We generated IRF5-deficient lupus (MRL/lpr) mice and investigated their phenotype. Autoantibodies to nuclear antigens, including anti-nuclear antibodies and anti-dsDNA antibodies were lower or negative in the mouse sera. Lupus nephritis was much milder, and the mice survive much longer than control MRL/lpr mice. Splenic dendritic cells produced lower levels of inflammatory cytokines in response to To l l-like receptor ligands. These results show that IRF5 is a crucial driver of lupus nephritis and indicate that IRF5 may be an attractive new target for the treatment of lupus nephritis.
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