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Role of the interferon regulatory factor 5 in the development of lupus nephritis

Research Project

Project/Area Number 22590893
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionSaga University

Principal Investigator

TADA Yoshifumi  佐賀大学, 医学部, 准教授 (70284627)

Co-Investigator(Kenkyū-buntansha) KOARADA Syuichi  佐賀大学, 医学部, 講師 (50304887)
NAGASAWA Kohei  佐賀大学, 佐賀大学, 教授 (00108721)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腎臓学 / 全身性エリテマトーデス / ループス腎炎 / インターフェロン調節因子 / Toll-like レセプター / siRNA / Toll-likeレセプター / インターフェロン制御因子
Research Abstract

Interferon regulatory factor 5 (IRF5) is a transcription factor and considered to be involved in the development of systemic lupus erythematosus. We generated IRF5-deficient lupus (MRL/lpr) mice and investigated their phenotype. Autoantibodies to nuclear antigens, including anti-nuclear antibodies and anti-dsDNA antibodies were lower or negative in the mouse sera. Lupus nephritis was much milder, and the mice survive much longer than control MRL/lpr mice. Splenic dendritic cells produced lower levels of inflammatory cytokines in response to To l l-like receptor ligands. These results show that IRF5 is a crucial driver of lupus nephritis and indicate that IRF5 may be an attractive new target for the treatment of lupus nephritis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (27 results)

All 2013 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 9 results) Presentation (12 results)

  • [Journal Article] 全身性エリテマトーデスとIRF52013

    • Author(s)
      多田芳史
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 59 Pages: 104-109

    • NAID

      40019567680

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Clinical factors to predict a poor prognosis and refractory disease in patients with polymyositis and dermatomyositis associated with interstitial lung disease2013

    • Author(s)
      Tada Y, Suematsu E, Ueda A, et al
    • Journal Title

      Clin Exp Rheumatol

      Volume: 30 Pages: 450-450

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RP105-negative B cells in systemic lupus erythematosus2012

    • Author(s)
      Koarada S, Tada Y
    • Journal Title

      Clin Dev Immunol

      Volume: 2012 Pages: 1-5

    • DOI

      10.1155/2012/259186

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phenotyping of P105-negative B cell subsets in patients with systemic lupus erythematosus2012

    • Author(s)
      Koarada S, Tada Y, Suematsu R, 他4名
    • Journal Title

      Clin Dev Immunol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population2012

    • Author(s)
      Kiyohara C, Washio M, Horiuchi T, Asami T, et al.
    • Journal Title

      Scand J Rheumatol

      Volume: 41 Issue: 2 Pages: 103-109

    • DOI

      10.3109/03009742.2011.608194

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRL/lprマウスのループス様病変発症にはIRF5が必須である2012

    • Author(s)
      多田芳史
    • Journal Title

      リウマチ科

      Volume: 46 Pages: 552-557

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 自己抗体産生RP105陰性B細胞上に発現するB-cell maturation antigenは、全身性エリテマトーデスの治療標的となりうるか2012

    • Author(s)
      小荒田秀一、田代知子, 他
    • Journal Title

      日本臨床免疫学会会誌

      Volume: 35 Pages: 38-45

    • NAID

      10030465586

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Phenotyping of RP105-negative B cell subsets in patients with systemic lupus erythematosus2012

    • Author(s)
      Koarada S, Tada Y, et al
    • Journal Title

      Clin Dev Immunol

      Volume: 2012 Pages: 198206-198206

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P-105 negative B cells in systemic lupus erythematosus2012

    • Author(s)
      Koarada S
    • Journal Title

      Clin Dev Immunol

      Volume: 2012 Pages: 259186-259186

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRL/lprマウスのループス様病変発症にはIRF5 が必須である2011

    • Author(s)
      多田芳史
    • Journal Title

      リウマチ科

      Volume: 46 Pages: 552-557

    • Related Report
      2012 Final Research Report
  • [Journal Article] Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice2011

    • Author(s)
      Tada Y, Kondo S, Aoki S, Koarada S, 他5名
    • Journal Title

      Arthritis Rheum

      Volume: 63 Issue: 3 Pages: 738-748

    • DOI

      10.1002/art.30183

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon regulatory factor 5 is critical for the development of lupus in MRL/1pr mice2011

    • Author(s)
      Tada Y, Kondo S, 他
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 738-748

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 全身性エリテマトーデスとインターフェロン -IFNα、IRF-5、Toll-ike receptorに関する最近の知見2010

    • Author(s)
      多田芳史
    • Journal Title

      九州リウマチ

      Volume: 30 Pages: 55-59

    • Related Report
      2012 Final Research Report
  • [Journal Article] Autoantibody-producing RP105-negative B cells.from patients with systemic lupus erythematosus, showed more preferential expression of BCMA copmared with BAFF-R than normal subjects2010

    • Author(s)
      Koarada S, Tada Y, Sohma Y, 他
    • Journal Title

      Rheumatology

      Volume: 49 Issue: 4 Pages: 662-670

    • DOI

      10.1093/rheumatology/kep437

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 全身性エリテマトーデスとインターフェロン-IFNα、IRF-5、Toll-likeレセプターに関する最近の知見-2010

    • Author(s)
      多田芳史
    • Journal Title

      九州リウマチ

      Volume: 30 Pages: 55-59

    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスコラーゲン関節炎におけるIRF5発現抑制の効果2013

    • Author(s)
      多田芳史、小荒田秀一、末松梨絵、田代知子、永尾奈津美、大田明英
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Increased novel human late B cell subsets of RP105-negative B cells in patients with systemic lupus erythematosus2012

    • Author(s)
      Koarada S, Ohta A, Tada Y
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] SLEおよび自己免疫疾患における自己抗体産生RP105陰性B細胞上のBCMA/BAFF-Rの発現の解析2012

    • Author(s)
      小荒田秀一、田代知子、末松梨絵、他3名
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] インターフェロン調節因子(IRF5)のループスマウスの病態発現における作用とそのメカニズム2011

    • Author(s)
      多田芳史、小荒田秀一, 他
    • Organizer
      日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] IRF5欠損MRL/lprマウスではTLRを介したサイトカイン産生か抑制される2011

    • Author(s)
      多田芳史、近藤誠司, 他
    • Organizer
      日本リウマチ学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] インターフェロン制御因子5(IRF5)のループスマウスの病態発現における作用とそのメカニズム2011

    • Author(s)
      多田芳史、小荒田秀一、青木茂久、他5名
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] IRF5欠損MRL/lprマウスではTLRを介したサイトカイン産生が抑制される.2011

    • Author(s)
      多田芳史、近藤誠司、小荒田秀一、他5名
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] SLE由来自己抗体産生RP105(-)B細胞のBCMAの発現-RP105(-)B細胞のフェノタイプ解析2011

    • Author(s)
      小荒田秀一、多田芳史、井上久子、他4名
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] IRF5はループスマウスの病態発現に重要な役割をはたす2010

    • Author(s)
      多田芳史、近藤誠司, 他
    • Organizer
      第54回日本リウマチ学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] IRF5はループスマウスの病態発現に重要な役割をはたす2010

    • Author(s)
      多田芳史、近藤誠司、小荒田秀一、長澤浩平
    • Organizer
      第30回福岡臨床免疫研究会
    • Place of Presentation
      福岡
    • Year and Date
      2010-01-23
    • Related Report
      2012 Final Research Report
  • [Presentation] IRF5はループスマウスの病態発現に重要な役割をはたす2010

    • Author(s)
      多田芳史、近藤誠司、小荒田秀一、他5名
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Interferon regulatory factor-5 (IRF-5) is critical for the development of lupus in MRL/lpr mice2010

    • Author(s)
      Tada Y, Koarada S, Aoki S, Koarada S,他4名
    • Organizer
      AmericanCollege of Rheumatology annual scientific meeting
    • Place of Presentation
      米国アトランタ
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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