The significance of Klotho in bone and mineral metabolism disorders in diabetes
| Project/Area Number |
22590895
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Yoshihiko 奈良県立医科大学, 医学部, 教授 (30250260)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | α-Klotho / 糖尿病性腎症 / 尿中カルシウム排泄 / 骨代謝マーカー / α－Klotho / TRPV5 / 分泌型α-Klotho / 膜型α-Klotho / FGF23 / 腎臓病 |
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| Research Abstract |
Renal α-Klotho expression was significantly lower and urinary calcium excretion significantly higher in diabetic nephropathy than in IgA nephropathy with an eGFR greater than 60 ml/min per 1.73m2 . Multiple regression analyses indicated that α-Klotho mRNA was inversely correlated with calcium excretion. We also confirmed a reduction of renal α-Klotho mRNA down to almost 50% and enhanced calcium excretion in mice with STZ-induced diabetic nephropathy in comparison with nondiabetic mice. Hypercalciuria was exacerbated in heterozygous α-Klotho knockout mice in comparison with wild-type mice, each with STZ-induced diabetic nephropathy. Thus, α-Klotho expression was decreased in distal convoluted tubules in diabetic nephropathy in humans and mice. Renal loss of α-Klotho may affect urinary calcium excretion in early diabetic nephropathy. However, we cannot confirm the direct associations of renal α-Klotho deficiency with bone metabolism abnormalities in diabetic nephropathy.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012
Author(s)
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
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Journal Title
Kidney Int
Volume: 81(6)
Pages: 539-47
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of fibroblast-specific protein-1 expression on podocytes in patients with focal segmental glomerulosclerosis2012
Author(s)
Samejima K, Nakatani K, Suzuki D, Asai O, Sakan H, Yoshimoto S, Yamaguchi Y, Matsui M, Akai Y, Toyoda M, Iwano M, Saito Y
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Journal Title
Nephron Clin Pract
Volume: 120(1)
Pages: 1-7
Related Report
Peer Reviewed
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[Journal Article] A new drug delivery system for intravenous coronary thrombolysis with thrombus -targeting and stealth activity recoverable by ultrasound2012
Author(s)
Kawata H, Uesugi Y, Soeda T, Takemoto Y, Sung JH, Umaki K, Kato K, Ogiwara K, Nogami K, Ishigami K, Horii M, Uemura S, Shima M, Tabata Y, Saito Y
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Journal Title
J Am Coll Cardiol
Volume: 60(24)
Pages: 2550-2557
Related Report
Peer Reviewed
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[Journal Article] Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis2012
Author(s)
Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y
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Journal Title
PNAS
Volume: 109(30)
Pages: 12064-12069
Related Report
Peer Reviewed
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[Journal Article] Decreased renalα-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012
Author(s)
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
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Journal Title
Kidney Int
Volume: 81(6)
Issue: 6
Pages: 539-47
DOI
Related Report
Peer Reviewed
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[Journal Article] Low-dose Aspirin Therapy in Patients With Type 2 Diabetes Mellitus and Reduced Glomerular Filtration Rate: Subanalysis from the JPAD Trial2011
Author(s)
Saito Y, Morimoto T, Ogawa H, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sugiyama S, Okada S, Akai Y
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Journal Title
Diabetes Care
Volume: 34(2)
Pages: 280-285
Related Report
Peer Reviewed
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[Journal Article] Macrophage Skewing by PHD2 Haplodeficiency Prevents Ischemia by Inducing Arteriogenesis2011
Author(s)
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyere F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M.
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Journal Title
Nature
Volume: 479(7371)
Pages: 122-126
Related Report
Peer Reviewed
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[Journal Article] Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects2010
Author(s)
Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T, Hataya H, Ichikawa S, Imel EA, Econs MJ, Nabeshima
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Journal Title
Biochem Biophys Res Commun
Volume: 398(3)
Pages: 513-518
Related Report
Peer Reviewed
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