| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
To study the interaction between Bmp7 and TGF-β intracellular signaling in renal tubular interstitial fibrosis, we used a mouse fibrosis model by unilateral ureteral obstruction (UUO). We compared the degree of renal tubular intestinal fibrosis caused by UUO using wild -type (WT) and Trps1 heterozygous KO (HT) mice. HT mice had more severe fibrosis than WT mice. From this experiment, we concluded that Trps1 functions downstream of Bmp7 and suppresses fibrosis by inhibiting Arkadia expression, suppressing TGF-β signaling.
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