| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Rho/ROCK pathway regulates various cellular functions. In this study, we found that Rho/ROCK pathway is activated in renal cortex of db/db mouse and involved in upregulation of pro-inflammatory cytokines in cultured mesangial cells, suggesting critical role of Rho/ROCK pathway played inthe pathogenesis of diabetic nephropathy.
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