Role of Rh/Rho-kinase pathway in the pathogenesis of diabetic nephropathy
| Project/Area Number |
22590900
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 糖尿病 / 糖尿病腎症 / Rho / Rhoキナーゼ / diabetic nephropathy / Rho-kinase / HIF-1α / diabettic nephropathy |
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| Research Abstract |
Rho/ROCK pathway regulates various cellular functions. In this study, we found that Rho/ROCK pathway is activated in renal cortex of db/db mouse and involved in upregulation of pro-inflammatory cytokines in cultured mesangial cells, suggesting critical role of Rho/ROCK pathway played inthe pathogenesis of diabetic nephropathy.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1a2013
Author(s)
Matoba K, Kawanami D, Okada R, Tsukamoto M, Kinoshita J, Ito T,Ishizawa S, Kanazawa Y, Yokota Y, Murai N, Matsufuji S, Utsunomiya K.
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Journal Title
Kideny Int
Volume: (in press)
Issue: 3
Pages: 545-554
DOI
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Peer Reviewed
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[Presentation] 糖尿病治療2011
Author(s)
宇都宮一典
Organizer
第11回日本動脈硬化学会教育フォーラム
Place of Presentation
東京
Year and Date
2011-02-06
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