| Project/Area Number |
22590901
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
IKEMORI Atsuko 聖マリアンナ医科大学, 医学部, 准教授 (80350635)
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| Co-Investigator(Kenkyū-buntansha) |
SUGAYA Takeshi 聖マリアンナ医科大学, 医学部, 客員教授 (40381561)
KIMURA Kenjiro 聖マリアンナ医科大学, 医学部, 教授 (00161555)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | L-FABP / 腎疾患 / 高血圧 / 治療 / 高血圧性腎障害 / アンジオテンシン II / 尿細管間質障害 / L型脂肪酸結合蛋白 / アンジオテンシンII / 脂肪酸結合蛋白 / 尿蛋白 / 腎臓 |
|---|
| Research Abstract |
Angiotensin II was infused systemically into human liver type fatty acid binding protein(L-FABP) chromosomal transgenic (Tg) and wild type (WT) mice for 4 weeks. Although blood pressure levels in both groups increased to a similar extent, expressions of inflammatory cytokines and collagen type I or III were significantly attenuated in the Tg mice compared to the WT mice. The expression of L-FABP increased in the Tg mice by Ang II infusion and the accumulation of peroxidative products was significantly inhibited in the Tg mice than in the WT mice. From these results, renal L-FABP attenuated the hypertensive renal injury independent on blood pressure.
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