Molecular analyses related therapeutic outcomes in renal allograft recipients

• Project/Area Number: 22590902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: YOKOYAMA Hitoshi 金沢医科大学, 医学部, 教授 (50191531)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Masaru 金沢医科大学, 医学部, 助教 (50319050) ; CHIKAZAWA Yoshihiro 金沢医科大学, 医学部, 助教 (80329408)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腎移植 / 疾患コホート / アディポサイトカイン / HLA-G / ケモカイン / アンジオテンシン受容体遮断薬 / 移植腎機能障害 / アディポネクチン / 尿アルブミン / ＭＣＰ－１ / アンジオテンシン受容体ブロッカー / スタチン / non classical HLA / MCP-1 / アデポネクチン / circulating fibrocyte / NK細胞

Research Abstract

We constructed prospectively the renal allograft recipient cohort including 120 subjects since 2007. We revealed the correlation between renal allograft function and the alteration of low-molecular weight adiponectin, the expression of non-classical HLA-G and clinical use of angiotensin-receptor blockers. We also found fibrocytes infiltration in acute ischemia-reperfusion injury of allografts and the activation of pericytes in interstitial fibrosis of chronic allograft injury.

Research Products

• [Journal Article] The effects of continuing and discontinuing smoking on the development of chronic (2013)
  • Author(s): Y.Noborisaka,M.Ishizaki,Y.Yamada,R.Honda,YokoyamaH,M.Miyao,M.Tabata
  • Journal Title: Environ. HealthPrevent. Med. Volume: 18(1) Pages: 24-32
  • Peer Reviewed
• [Journal Article] The effects of continuing and discontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working population in Japan. (2013)
  • Author(s): Noborisaka Y
  • Journal Title: Environ Health Prev Med Volume: 18(1) Issue: 1 Pages: 24-32
  • DOI: 10.1007/s12199-012-0285-7
  • NAID: 10031143688
  • ISSN: 1342-078X, 1347-4715
  • Peer Reviewed
• [Journal Article] Membranous nephropathy in Japan: analysis of the Japan Renal Biopsy Registry (J-RBR) (2012)
  • Author(s): Yokoyama H,T.Taguchi,H.Sugiyama,H.Sato
  • Journal Title: Clin. Exp.Nephrol. Volume: 16(4) Pages: 557-563
  • NAID: 10031058116
  • Peer Reviewed
• [Journal Article] Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR), Clin. (2012)
  • Author(s): YokoyamaH,etal
  • Journal Title: Exp.Nephrol. Volume: 16(6) Pages: 903-920
  • Peer Reviewed
• [Journal Article] Cigarette smoking, proteinuria,and renal function in middle-aged Japanese men from an occupational population, Environ. (2012)
  • Author(s): Y.Noborisaka,M.Ishizaki,M.Nakata,Y.Yamada,R.Honda,YokoyamaH,M.Miyao,M.Tabata
  • Journal Title: Environ.Health Prevent.Med. Volume: 17 Pages: 147-156
  • Peer Reviewed
• [Journal Article] Circulating fibrocytes in ischemia-reperfusion injury and chronic renal allograft fibrosis,Nephron Clin. Pract. (2012)
  • Author(s): S.Kimura,M.Asaka,H.Atsumi,J.Imura,K.Fujimoto,Y.Chikazawa,M.Nakagawa,H.Okuyama,H.Yamaya,YokoyamaH
  • Journal Title: Nephron Clin.Pract. Volume: 121(1-2) Pages: 16-24
  • Peer Reviewed
• [Journal Article] Membranous nephropathy in Japan: analysis of the Japan Renal Biopsy Registry (J-RBR). (2012)
  • Author(s): Yokoyama H
  • Journal Title: Clin Exp Nephrol Volume: 16(4) Pages: 557-563
  • DOI: 10.1007/s10157-012-0593-7
  • NAID: 10031058116
  • Peer Reviewed
• [Journal Article] Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). (2012)
  • Author(s): Yokoyama H
  • Journal Title: Clin Exp Nephrol Volume: 16(6) Pages: 903-20
  • DOI: 10.1007/s10157-012-0673-8
  • NAID: 10031145922
  • Peer Reviewed
• [Journal Article] Circulating fibrocytes in ischemia-reperfusion injury and chronic renal allograft fibrosis. (2012)
  • Author(s): Kimura S
  • Journal Title: Nephron Clin Pract Volume: 121(1-2)
  • DOI: 10.1159/000341374
  • Peer Reviewed
• [Journal Article] Cigarette smoking, proteinuria, ad renal function in middle-aged Japanese men from an occupational population (2012)
  • Author(s): Yuka Noborisaka
  • Journal Title: Environ Health Prev Med Volume: 17 Issue: 2 Pages: 147-156
  • DOI: 10.1007/s12199-011-0234-x
  • ISSN: 1342-078X, 1347-4715
  • Peer Reviewed
• [Journal Article] Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan (2011)
  • Author(s): H.Sugiyama,YokoyamaH,H.Sato,T.Sito,Y.Kohda,S.Hishi,K.Tsuruya,H.Kiyomoto,H.Iida,T.Sasaki,M.Higuchi,M.Hattori,K.Oka,S.Kagami,M.Nagata,T.Kawamura,M.Honda,Y.Fukasawa,Wada
  • Journal Title: Transplant. Volume: 26 Pages: 3124-3131
  • NAID: 10029571676
  • Peer Reviewed
• [Journal Article] Clinicopathological insights into lupus glomerulonephritis in Japanese and Asians (2011)
  • Author(s): Yokoyama H,H.Okuyama,H.Yamaya
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 321-330
  • NAID: 10029005530
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats. (2011)
  • Author(s): K.Furuichi,Y.Hisada,M.Shimizu,T.Okumura,K.Kitagawa,K.Yoshimoto,Y.Iwata,H.Yokoyama,S.Kaneko,T.Wada
  • Journal Title: Nephrol. Transplant. Volume: 26 Pages: 3124-3131
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats (2011)
  • Author(s): Furuichi K
  • Journal Title: Nephrol Dial Transplant Volume: 26(10) Pages: 3124-3131
  • DOI: 10.1093/ndt/gfr125
  • Peer Reviewed
• [Journal Article] Japan Renal Biopsy Registry: the first nationwide, web-based,and prospective registry system of renal biopsies in Japan (2011)
  • Author(s): Sugiyama H, Joh K
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 493-503
  • DOI: 10.1007/s10157-011-0430-4
  • Peer Reviewed
• [Journal Article] Clinicopathological insights into lupus glomerulonephritis of Japanese and Asians (2011)
  • Author(s): H.Yokoyama
  • Journal Title: Clin Exp Nephrol Volume: 15(3) Pages: 321-330
  • DOI: 10.1007/s10157-011-0434-0
  • NAID: 10029005530
  • Peer Reviewed
• [Journal Article] Clinicopathological insights into lupus glomerulonephritis of Japanese and Asians (2011)
  • Author(s): H.Yokoyanra
  • Journal Title: Clin Exp Nephrol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Effectiveness of weekly percutaneous maxacalcitol injection therapy in patients with secondary hyperparathyroidism (2010)
  • Author(s): A.Saito,Y.Matsumoto,H.Okuyama,M.Asaka,Yokoyama H
  • Journal Title: TherApherDial Volume: 14 Pages: 98-103
  • Peer Reviewed
• [Journal Article] Long-term natural history of acquired cystic disease of the kidney. (2010)
  • Author(s): I.Ishikawa,S.Hayama,K.Morita,T.Nakazawa,H.Yokoyama,R.Honda,K.Satoh,T.Kakuma
  • Journal Title: Ther Apher Dial Volume: 14 Pages: 409-416
  • Peer Reviewed
• [Journal Article] A case of second renal transplantation with acute antibody-mediated rejection complicated with BK virus nephropathy (2010)
  • Author(s): H.Atsumi,M.Asaka,S.Kimura,J.Imura,K.Fujimoto,Y.Chikazawa,M.Nakagawa,H.Okuyama,H.Yamaya,M.Moriyama,T.Tanaka,K.Suzuki,H.Yokoyama
  • Journal Title: Clin Transplant. Volume: 24 Pages: 35-38
  • Peer Reviewed
• [Journal Article] A case of second renal transplantation with acute antibody-mediated rejection complicated with BK virus nephropathy. (2010)
  • Author(s): H.Atsumi
  • Journal Title: Clin Transplant Volume: 24 Pages: 35-38
  • Peer Reviewed
• [Presentation] 腎移植患者におけるイルベサルタンとロサルタンの腎保護効果の検討 (2012)
  • Author(s): 山谷秀喜,松井佑樹,林憲史,井村淳子,藤本圭司,羽山智之,近澤芳寛,中川卓,奥山宏,横山仁
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Cinacalcet loading test predicts the effect of long-term cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism (2011)
  • Author(s): 横山仁, 他
  • Organizer: ASN's 44rd Annual Meeting and Scientific Exposition
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2011-11-12
• [Presentation] A new insight into circulating fibrocytes and peritubular pericytes in renal allograft nephropathy , XLVIII ERA-EDTA Congress (2011)
  • Author(s): S.Kimura,J.Imura,H.Atsumi,K.Fujimoto,Y.Chikazawa,M.Nakagawa,S.Hayama,H.Okuyama,H.Yamaya,H.Yokoyama
  • Organizer: XLVIIIERA-EDTA Congress
  • Place of Presentation: Prague
• [Presentation] Non-Immunological Factors and Non-Classical HLA Class I in Chronic Allograft Injury (2010)
  • Author(s): 横山仁, 他
  • Organizer: ASN's 43rd Annual Meeting and Scientific Exposition
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2010-11-20
• [Presentation] Statins and lower LDL-C/HDL-C ratio preserved the function of transplanted kidneys under controlled blood pressure (2010)
  • Author(s): H.Yamaya,H.Adachi,S.Kimura,M.Asaka,H.Yokoyama
  • Organizer: The kidney and the vascular system:emerging culprits in pathogenesis and advances in therapy
  • Place of Presentation: Kyoto
• [Presentation] 腎移植患者におけるイルベサルタンとロサルタンの腎保護効果の検討
  • Author(s): 山谷秀喜
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜国際会議場（横浜）
• [Presentation] ～腎保護の立場から～From the Position of Renal Protection
  • Author(s): 横山 仁
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ウエスチンホテル名古屋（名古屋）
• [Book] 変革する透析医学,2章保存期慢性腎臓病(CKD)管理の意義と重要性 (2012)
  • Author(s): 横山仁,杉山斉,佐藤博,今井圓裕
  • Publisher: 医学ジャーナル
• [Book] AnnualReview腎臓2012 (2012)
  • Author(s): 横山仁
  • Publisher: 中外医学社
• [Book] 変革する透析医学， 2章 保存期慢性腎臓病（CKD)管理の意義と重要性 1. 保存期CKD管理の現状 (2012)
  • Author(s): 横山 仁
  • Total Pages: 498
  • Publisher: 医学ジャーナル
• [Book] AnnualReview腎臓2010 (2010)
  • Author(s): 横山仁
  • Publisher: 中外医学社