• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular analyses related therapeutic outcomes in renal allograft recipients

Research Project

Project/Area Number 22590902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKanazawa Medical University

Principal Investigator

YOKOYAMA Hitoshi  金沢医科大学, 医学部, 教授 (50191531)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Masaru  金沢医科大学, 医学部, 助教 (50319050)
CHIKAZAWA Yoshihiro  金沢医科大学, 医学部, 助教 (80329408)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腎移植 / 疾患コホート / アディポサイトカイン / HLA-G / ケモカイン / アンジオテンシン受容体遮断薬 / 移植腎機能障害 / アディポネクチン / 尿アルブミン / MCP-1 / アンジオテンシン受容体ブロッカー / スタチン / non classical HLA / MCP-1 / アデポネクチン / circulating fibrocyte / NK細胞
Research Abstract

We constructed prospectively the renal allograft recipient cohort including 120 subjects since 2007. We revealed the correlation between renal allograft function and the alteration of low-molecular weight adiponectin, the expression of non-classical HLA-G and clinical use of angiotensin-receptor blockers. We also found fibrocytes infiltration in acute ischemia-reperfusion injury of allografts and the activation of pericytes in interstitial fibrosis of chronic allograft injury.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2013 2012 2011 2010 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (7 results) Book (4 results)

  • [Journal Article] The effects of continuing and discontinuing smoking on the development of chronic2013

    • Author(s)
      Y.Noborisaka,M.Ishizaki,Y.Yamada,R.Honda,YokoyamaH,M.Miyao,M.Tabata
    • Journal Title

      Environ. HealthPrevent. Med.

      Volume: 18(1) Pages: 24-32

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of continuing and discontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working population in Japan.2013

    • Author(s)
      Noborisaka Y
    • Journal Title

      Environ Health Prev Med

      Volume: 18(1) Issue: 1 Pages: 24-32

    • DOI

      10.1007/s12199-012-0285-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membranous nephropathy in Japan: analysis of the Japan Renal Biopsy Registry (J-RBR)2012

    • Author(s)
      Yokoyama H,T.Taguchi,H.Sugiyama,H.Sato
    • Journal Title

      Clin. Exp.Nephrol.

      Volume: 16(4) Pages: 557-563

    • NAID

      10031058116

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR), Clin.2012

    • Author(s)
      YokoyamaH,etal
    • Journal Title

      Exp.Nephrol.

      Volume: 16(6) Pages: 903-920

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking, proteinuria,and renal function in middle-aged Japanese men from an occupational population, Environ.2012

    • Author(s)
      Y.Noborisaka,M.Ishizaki,M.Nakata,Y.Yamada,R.Honda,YokoyamaH,M.Miyao,M.Tabata
    • Journal Title

      Environ.Health Prevent.Med.

      Volume: 17 Pages: 147-156

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating fibrocytes in ischemia-reperfusion injury and chronic renal allograft fibrosis,Nephron Clin. Pract.2012

    • Author(s)
      S.Kimura,M.Asaka,H.Atsumi,J.Imura,K.Fujimoto,Y.Chikazawa,M.Nakagawa,H.Okuyama,H.Yamaya,YokoyamaH
    • Journal Title

      Nephron Clin.Pract.

      Volume: 121(1-2) Pages: 16-24

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membranous nephropathy in Japan : analysis of the Japan Renal Biopsy Registry (J-RBR)2012

    • Author(s)
      Yokoyama H
    • Journal Title

      Clin Exp Nephrol

      Volume: (In press) Issue: 4 Pages: 557-563

    • DOI

      10.1007/s10157-012-0593-7

    • NAID

      10031058116

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal disease in the elderly and the very elderly Japanese: Analysis of the Japan Renal Biopsy Registry (J-RBR)2012

    • Author(s)
      Yokoyama H
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Issue: 6 Pages: 903

    • DOI

      10.1007/s10157-012-0673-8

    • NAID

      10031145922

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating fibrocytes in ischemia-reperfusion injury and chronic renal allograft fibrosis.2012

    • Author(s)
      Kimura S
    • Journal Title

      Nephron Clin Pract

      Volume: 121(1-2) Issue: 1-2 Pages: c16-c24

    • DOI

      10.1159/000341374

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking, proteinuria, ad renal function in middle-aged Japanese men from an occupational population2012

    • Author(s)
      Yuka Noborisaka
    • Journal Title

      Environ Health Prev Med

      Volume: 17 Issue: 2 Pages: 147-156

    • DOI

      10.1007/s12199-011-0234-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan2011

    • Author(s)
      H.Sugiyama,YokoyamaH,H.Sato,T.Sito,Y.Kohda,S.Hishi,K.Tsuruya,H.Kiyomoto,H.Iida,T.Sasaki,M.Higuchi,M.Hattori,K.Oka,S.Kagami,M.Nagata,T.Kawamura,M.Honda,Y.Fukasawa,Wada
    • Journal Title

      Transplant.

      Volume: 26 Pages: 3124-3131

    • NAID

      10029571676

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological insights into lupus glomerulonephritis in Japanese and Asians2011

    • Author(s)
      Yokoyama H,H.Okuyama,H.Yamaya
    • Journal Title

      Clin Exp Nephrol

      Volume: 15 Pages: 321-330

    • NAID

      10029005530

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats.2011

    • Author(s)
      K.Furuichi,Y.Hisada,M.Shimizu,T.Okumura,K.Kitagawa,K.Yoshimoto,Y.Iwata,H.Yokoyama,S.Kaneko,T.Wada
    • Journal Title

      Nephrol. Transplant.

      Volume: 26 Pages: 3124-3131

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats2011

    • Author(s)
      Furuichi K
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26(10) Issue: 10 Pages: 3124-3131

    • DOI

      10.1093/ndt/gfr125

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japan Renal Biopsy Registry: the first nationwide, web-based,and prospective registry system of renal biopsies in Japan2011

    • Author(s)
      Sugiyama H, Joh K
    • Journal Title

      ClinExpNephrol

      Volume: 15 Issue: 4 Pages: 493-503

    • DOI

      10.1007/s10157-011-0430-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological insights into lupus glomerulonephritis of Japanese and Asians2011

    • Author(s)
      H.Yokoyama
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(3) Issue: 3 Pages: 321-330

    • DOI

      10.1007/s10157-011-0434-0

    • NAID

      10029005530

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological insights into lupus glomerulonephritis of Japanese and Asians2011

    • Author(s)
      H.Yokoyanra
    • Journal Title

      Clin Exp Nephrol

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of weekly percutaneous maxacalcitol injection therapy in patients with secondary hyperparathyroidism2010

    • Author(s)
      A.Saito,Y.Matsumoto,H.Okuyama,M.Asaka,Yokoyama H
    • Journal Title

      TherApherDial

      Volume: 14 Pages: 98-103

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term natural history of acquired cystic disease of the kidney.2010

    • Author(s)
      I.Ishikawa,S.Hayama,K.Morita,T.Nakazawa,H.Yokoyama,R.Honda,K.Satoh,T.Kakuma
    • Journal Title

      Ther Apher Dial

      Volume: 14 Pages: 409-416

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of second renal transplantation with acute antibody-mediated rejection complicated with BK virus nephropathy2010

    • Author(s)
      H.Atsumi,M.Asaka,S.Kimura,J.Imura,K.Fujimoto,Y.Chikazawa,M.Nakagawa,H.Okuyama,H.Yamaya,M.Moriyama,T.Tanaka,K.Suzuki,H.Yokoyama
    • Journal Title

      Clin Transplant.

      Volume: 24 Pages: 35-38

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of second renal transplantation with acute antibody-mediated rejection complicated with BK virus nephropathy.2010

    • Author(s)
      H.Atsumi
    • Journal Title

      Clin Transplant

      Volume: 24 Pages: 35-38

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腎移植患者におけるイルベサルタンとロサルタンの腎保護効果の検討2012

    • Author(s)
      山谷秀喜,松井佑樹,林憲史,井村淳子,藤本圭司,羽山智之,近澤芳寛,中川卓,奥山宏,横山仁
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Cinacalcet loading test predicts the effect of long-term cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism2011

    • Author(s)
      横山仁, 他
    • Organizer
      ASN's 44rd Annual Meeting and Scientific Exposition
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] A new insight into circulating fibrocytes and peritubular pericytes in renal allograft nephropathy , XLVIII ERA-EDTA Congress2011

    • Author(s)
      S.Kimura,J.Imura,H.Atsumi,K.Fujimoto,Y.Chikazawa,M.Nakagawa,S.Hayama,H.Okuyama,H.Yamaya,H.Yokoyama
    • Organizer
      XLVIIIERA-EDTA Congress
    • Place of Presentation
      Prague
    • Related Report
      2012 Final Research Report
  • [Presentation] Non-Immunological Factors and Non-Classical HLA Class I in Chronic Allograft Injury2010

    • Author(s)
      横山仁, 他
    • Organizer
      ASN's 43rd Annual Meeting and Scientific Exposition
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Statins and lower LDL-C/HDL-C ratio preserved the function of transplanted kidneys under controlled blood pressure2010

    • Author(s)
      H.Yamaya,H.Adachi,S.Kimura,M.Asaka,H.Yokoyama
    • Organizer
      The kidney and the vascular system:emerging culprits in pathogenesis and advances in therapy
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎移植患者におけるイルベサルタンとロサルタンの腎保護効果の検討

    • Author(s)
      山谷秀喜
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜国際会議場(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ~腎保護の立場から~From the Position of Renal Protection

    • Author(s)
      横山 仁
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウエスチンホテル名古屋(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Book] 変革する透析医学,2章保存期慢性腎臓病(CKD)管理の意義と重要性2012

    • Author(s)
      横山仁,杉山斉,佐藤博,今井圓裕
    • Publisher
      医学ジャーナル
    • Related Report
      2012 Final Research Report
  • [Book] AnnualReview腎臓20122012

    • Author(s)
      横山仁
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 変革する透析医学, 2章 保存期慢性腎臓病(CKD)管理の意義と重要性 1. 保存期CKD管理の現状2012

    • Author(s)
      横山 仁
    • Total Pages
      498
    • Publisher
      医学ジャーナル
    • Related Report
      2012 Annual Research Report
  • [Book] AnnualReview腎臓20102010

    • Author(s)
      横山仁
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi