Missing link between metabolic syndrome and chronic kidney disease.?Role of asymmetric dimethylarginine-
Project/Area Number |
22590903
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Kurume University |
Principal Investigator |
OKUDA Seiya 久留米大学, 医学部, 教授 (80158823)
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Co-Investigator(Kenkyū-buntansha) |
UEDA Seiji 久留米大学, 医学部, 准教授 (80322593)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | メタボリック症候群 / インスリン抵抗性 / 慢性腎臓病 / ADMA / 内皮障害 / 心腎連関 / CKD / 内皮機能障害 / DDAH / 微量アルブミン尿 / 脂肪細胞 |
Research Abstract |
Metabolic syndrome (MetS) is a strong risk factor for the initiation and development of chronic kidney disease (CKD). One possible factor that could explain this link seems to be endothelial dysfunction (ED). In CKD patients, ADMA levels were associated with metabolic factors and eGFR. Further, increased ADMA levels were associated with surrogate markers for cardiovascular disease as well as annual reduction rates of GFR. Animal models of MetS revealed that dysregulation of DDAH, an enzyme for ADMA could account for ADMA elevation, and therefore could contributed to the development and progression of cardiovascular disease as well as renal injury in Mets.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article]2009
Author(s)
Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S.
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Journal Title
Nephrol Dial Transplant.
Volume: 24(4)
Pages: 1162-9
Related Report
Peer Reviewed
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[Journal Article] Involvement of advanced glycation end product?induced asymmetric dimethylarginine generation in endothelial dysfunction.
Author(s)
Ando R, Ueda S, Yamagishi S, Miyazaki H, Kaida Y, Kaifu K, Yokoro M, Nakayama Y, Obara N, Fukami K, Takeuchi M, Okuda S.
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Journal Title
Diabetes & Vascular Disease Research.
Related Report
Peer Reviewed
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