Novel therapeutic approach against receptor for advanced glycation end products in patients with diabetic nephropathy or RPGN.
| Project/Area Number |
22590904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
FUKAMI Kei 久留米大学, 医学部, 准教授 (80309781)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | diabetic nephropathy / RPGN / glycation / RAGE / AGEs / aptamer / 糖尿病性腎症 / アプタマー / Diabetic Nephropathy |
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| Research Abstract |
Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. We examined effects of AGE- and RAGE-aptamer on renal injury in KKAy/Ta mice. Glomerular AGEs levels were significantly increased in KKAy/Ta mice, which were blocked by AGEs-aptamer. Urinary albumin and 8-hydroxy-2’-deoxy-guanosine levels were increased, and glomerular hypertrophy and extracellular matrix accumulation were prevented by AGEs-aptamer. Our present data suggest that continuous administration of AGEs-aptamer may be a feasible and promising therapeutic strategy for the treatment of diabeticnephropathy.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.2013
Author(s)
Kaida Y, Fukami K, Matsui T, Higashimoto Y, Nishino Y, Obara N, Nakayama Y, Ando R, Toyonaga M, Ueda S, Takeuchi M, Inoue, H, Okuda S, Yamagishi
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Journal Title
Diabetes(S. Kaida Y and Fukami K contributed equally to this study)
Related Report
Peer Reviewed
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[Journal Article] Effects of Switching from Calcium Carbonate to Lanthanum Carbonate on Bone Mineral Metabolism in Hemodialysis Patients.2013
Author(s)
Manabe R, Fukami K, Ando R, Sakai K, Kusumoto T, Hazama H, Adachi T, Kaida K, Nakayama N, Ueda S, Kohno K, Wada Y, Yamagishi S, Okuda S.
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Journal Title
Ther Apher Dial. 17Suppl
Volume: 1
Pages: 35-40
Related Report
Peer Reviewed
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[Journal Article] Experimentaldiabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice.2013
Author(s)
Takamiya Y, Fukami K, Yamagishi S, Kaida Y, Nakayama Y, Obara N, Iwatani R, Ando R, Koike K, Matsui M, Nishino Y, Ueda S, Cooper ME, and Okuda S.
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Journal Title
Nephrol Dial Transplant.
Volume: 28(1)
Pages: 55-62
Related Report
Peer Reviewed
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[Journal Article] A new vasculitis activity score for predicting deathin myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis patients.2011
Author(s)
Koike K, Fukami K, Yonemoto K, Iwatani R, Obara N, Ueda K,Toyonaga M, Ueda S, Ohara A, Takeda K, Yamagishi S, Okuda S.
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Journal Title
Am J Nephrol.
Volume: 35(1)
Pages: 1-6
Related Report
Peer Reviewed
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[Journal Article] A new vasculitis activity score for predicting death in myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis patients2011
Author(s)
Koike K, Fukami K, Yonemoto K, Iwatani R, Obara N, Ueda K, Toyonaga M, Ueda S, Ohara A, Takeda K, Yamagishi S, Okuda S
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Journal Title
Am J Nephrol
Volume: 35
Issue: 1
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Presentation] DNA aptamers raised against AGEs improve diabetic nephropathy in KK/Ay-Ta mice.2011
Author(s)
Yusuke Kaida , Kei Fukami, Sho-ichiYamagishi, Yuichiro Higashimoto, Nana Obara, Ryotaro Ando, Yosuke Nakayama, Masayoshi Takeuchi, Takanori Matsui, Seiji Ueda, Hiroyoshi Inoue, Seiya Okuda.
Organizer
American Society of Nephrology.
Place of Presentation
Philadelphia, Pennsylvania
Related Report
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[Presentation] DNA aptamers raised against AGEs improve diabetic nephropathy in KK/Ay-Ta miceDNA aptamers raised against AGEs improve diabetic nephropathy in KK/Ay-Ta miceKei Fukami, Sho-ichi Yamagishi, Yuichiro Higashimoto2011
Author(s)
Yusuke Kaida, Ryuji Iwatani, Ryotaro Ando, Yosuke Nakayama, Masayoshi Takeuchi, Takanori Matsui, Seiji Ueda, Hiroyoshi Inoue, Seiya Okuda.
Organizer
International Society of Nephrology.
Place of Presentation
Vancouver, Canada.
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