| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Chronic angiotensin II (Ang II) infusion promotes renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II in GC-A-deficient mice (GC-A-KO) and wild mice. The natriuretic peptide-GC-A system may play an inhibitory role in Ang II-induced renal tubular atrophy, interstitial fibrosis, and phenotypic transformation in renal tubular cells and fibroblasts. Renal blood flow evaluated using microspheres was significantly lower in GC-A-KO mice than that in wild mice. The reduction of renal blood flow in GC-A-KO mice relative to that in wild mice may be one possibility for advanced renal tubular damage and interstitial fibrosis in Ang II-infused GC-A-KO.
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