Basic Research toward Discovery for New Renal Treatment using Bioactive Peptides
| Project/Area Number |
22590906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
YOSHIHARA Fumiki 独立行政法人国立循環器病研究センター, 病院, 医長 (70393220)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUDOME Takeshi 独立行政法人国立循環器病研究センター, 研究所, 室長 (00443474)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生理活性ペプチド / 腎疾患 |
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| Research Abstract |
Chronic angiotensin II (Ang II) infusion promotes renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II in GC-A-deficient mice (GC-A-KO) and wild mice. The natriuretic peptide-GC-A system may play an inhibitory role in Ang II-induced renal tubular atrophy, interstitial fibrosis, and phenotypic transformation in renal tubular cells and fibroblasts. Renal blood flow evaluated using microspheres was significantly lower in GC-A-KO mice than that in wild mice. The reduction of renal blood flow in GC-A-KO mice relative to that in wild mice may be one possibility for advanced renal tubular damage and interstitial fibrosis in Ang II-infused GC-A-KO.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population.2011
Author(s)
Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y.
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Journal Title
Hypertens Res.
Volume: 34(6)
Pages: 740-746
NAID
Related Report
Peer Reviewed
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[Presentation] Impact of Hypoalbuminemia on Acute Kidney Injury in Patients with Acute Decompensated Heart Failure -Possible Relation of Atrial Natriuretic Peptide-2013
Author(s)
Yoichi Takaya, Fumiki Yoshihara, Hiroyuki Yokoyama, Hideaki Kanzaki, Masafumi Kitakaze, Yoichi Goto, Toshihisa Anzai, Satoshi Yasuda, Yuhei Kawano, Hisao Ogawa, Kenji Kangawa
Organizer
第77回日本循環器学会学術集会
Place of Presentation
横浜
Related Report
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