Role of interstitial sodium accumulation on inflammatory cytokines and lymphcapillary reconstruction in salt-sensitive hypertension.

• Project/Area Number: 22590907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Gunma University
• Principal Investigator: NAKAMURA Tetsya 群馬大学, 医学部, 准教授 (10272238)
• Co-Investigator(Renkei-kenkyūsha): KURABAYASHI Masahiko (00215047) ; SAITO Yuichiro (30344922)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 高血圧学 / 圧ナトリウム利尿曲線 / 循環器・高血圧 / 内科 / 発現制御

Research Abstract

In vascular endothelial cells, the active form of human heat shock factor-1 (HSF1) raised the levels of endothelial nitric oxide synthase (relaxation factor) and thrombomodulin (anticoagulation factor). The gene expression of oxidative stress was elevated in renal medulla in salt-sensitive hypertensive rats. The results suggestthat renal lymphcapillary reconstruction should reduce renal medullary blood flow, induce the rightward shift of the pressure-natriuresis curve and lead to the development of salt-sensitive hypertension.

Research Products

• [Journal Article] on behalf of the RAISE study group investigators (2012)
  • Author(s): Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M, Nomura Y, Fuse S, Ichida F, Seki M, Fukazawa R, Ogawa C, Furuno K, Tokunaga H, Takatsuki S, Hara S, Morikawa A
  • Journal Title: Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. Lancet Volume: 379 Pages: 1613-1620
  • Peer Reviewed
• [Journal Article] Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion (2011)
  • Author(s): Uchiyama T, Tomono S, Utsugi T, Ohyama Y, Nakamura T, Tomura H, Kawazu S, Okajima F, Kurabayashi M.
  • Journal Title: Metabolism Clinical and Experimental Volume: 60 Pages: 789-798
  • Peer Reviewed
• [Journal Article] Constitutively active heat shock factor 1 enhances glucose-driven insulinsecretion (2011)
  • Author(s): Uchiyama T
  • Journal Title: Metabolism Clinical and Experimental Volume: 60 Pages: 789-798
  • Peer Reviewed
• [Journal Article] Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion (2010)
  • Author(s): 内山強
  • Journal Title: Metabolism Clinical and Experimental Volume: (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 常時活性型 Heat shock factor 1 は insulin 分泌を促進させる。糖尿 病55(Suppl 1): S-350, 2012 (2012)
  • Author(s): 内山強、伴野祥一、 中 村 哲 也、倉 林 正 彦、岡島史和
  • Organizer: 第55回日本糖 尿病学会年次学術集会
• [Presentation] Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasakisisease: a prospective, randomised, open, blinded-endpoint trial. (2012)
  • Author(s): Kobayashi T, Saji T, Takeuchi K, Nakamura T, Arakawa H, Ogawa S, Miura M, Nomura Y, Ichida F, Seki M, Morikawa A.
  • Organizer: Circ J 76(Suppl. I):I-550, 2012 The 76th annual scientific meeting of the Japanese Circulation Society
• [Presentation] The RAISE Study Investigators. Abstract 9271: Significance of primary therapy with intravenous immunoglobulin plus predonisolone for severe Kawasaki disease: result from Japanese multicenter randomized clinical trial (2011)
  • Author(s): Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M, Nomura Y, Fuse S, Ichida F, Seki M, Morikawa A
  • Organizer: Circulation124: A17014, 2011.
  • Place of Presentation: Scientific Sessions2011, American Heart Association
• [Presentation] 重症川崎病患者に対する免疫グロブリンと免疫グロブリン・プレドニゾロン初期併用投与のランダム化比較試験(RAISEStudy)-データセンターの取り組み- (2011)
  • Author(s): 中村哲也、小林徹、荒川浩一、佐地勉
  • Organizer: 第38回日本小児臨床薬理学会
• [Presentation] Heat shock facor-1 と 活性型 Heat shock factor-1 は血管内皮細胞 機能を改善する。-プログラム・抄録集-394頁 (2011)
  • Author(s): 内山強、 中村 哲也、斎藤勇 一郎 、伴野祥一、 岡島史和、倉林正彦
  • Organizer: 第34回日本高血圧学会総会
• [Book] 高血圧治療における配合剤処方の意義 (2011)
  • Author(s): 中村哲也
  • Publisher: 高崎医学
• [Book] 高血圧/セミナー 高血圧の発生機序とその治療ストラテジー これからの降圧薬の使い 方 最適な降圧薬の組み合わせ -併用療法と 合剤のこれから- (2011)
  • Author(s): 斎藤勇 一郎 、中村哲也、倉林正彦