Evaluation of the mechanisms to progress hypertension and kidney injury in high fat loading during young age
| Project/Area Number |
22590908
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ANDO Katsuyuki 東京大学, 医学部附属病院, 特任准教授 (60184313)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肥満 / 高血圧 / 腎障害 / 幼若期 / 食塩 / 幼若期肥満 / 食塩感受性高血圧 / ミネラルコルチコイド受容体 / Dah1S.Z-Lepr^<fa>ラット / DahlS.Z-Lepr^<fa>ラット |
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| Research Abstract |
To elucidate the relationship of obesity and high salt intake due to overeating during young age in the progress of hypertension, the effects of restriction of dietary amount, salt, and both were examined in in DahlS.Z-Leprfa rats, which show obesity, hypertension, and kidney injury during young age. As a result, these treatments ameliorate hypertension and the associated kidney injury. Thus, dietary factors during young age may play an important role of hypertension. In addition, the present data suggests contribution of aldosterone in development of hypertension at young age.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Rac1 GTPase in rodent kidneys is essentialfor salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.2011
Author(s)
Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T.
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Journal Title
J Clin Invest.
Volume: 121
Pages: 3233-3243
Related Report
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[Journal Article] Rationale, design, and baseline data of the Japanese Primary Prevention Project (JPPP)A randomized open-label controlled trial of versus no aspirin in patients with multiple risk factors for vascular events.2010
Author(s)
Teramoto T, Shimada K, Uchiyama S, Sugawara M, Goto Y, Yamada N, Oikawa S, Ando K, Ishizuka N, Yamazaki T, Yokoyama K, Murata M, Ikeda Y
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