| Project/Area Number |
22590909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Research Collaborator |
SUZUKI Jinya 福井大学, 医学部, 助教 (20293417)
ARAKAWA Kenichiro 福井大学, 医学部, 助教 (80401967)
ZENIMARU Yasuo 福井大学, 医学部附属病院, 医員 (20397269)
FUJII Miki 福井大学, 医学部附属病院, 医員 (10401978)
IMAGAWA Michiko 福井大学, 医学部附属病院, 医員 (70464055)
ICHIKAWA Mai 福井大学, 医学部附属病院, 医員 (30646659)
YAMADA Mika 福井大学, 医学部附属病院, 医員 (90646655)
MAKINO Yasukazu 福井大学, 医学部, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | レニン-アンジオテンシン系 / 網羅的発現遺伝子解析 / AT4/IRAP / 高血圧 / 糖尿病 / 腎臓 / インスリン / アミノペプチダーゼ / ＡＴ４／ＩＲＡＰ |
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| Research Abstract |
We have identified AT4/IRAP as a hypertension/diabetes-specific gene through systemic transcriptome analysis followed by RT-PCR. This protein is thought to be involved in the renin-angiotensin system and insulin signal transduction. We have established a measurement system by ELISA. Thereby for the first time we could suggest the possibility that AT4/IRAP might be involved in the pathophysiology of life-style related diseases.
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