• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Search for genes responsible for stress-induced hypertension in SHRSPcongenic rats.

Research Project

Project/Area Number 22590911
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionShimane University

Principal Investigator

NABIKA Toru  島根大学, 医学部, 教授 (50180534)

Co-Investigator(Kenkyū-buntansha) HARADA Yuji  島根大学, 医学部, 准教授 (60228658)
CUI Zh  島根大学, 医学部, 助教 (50379690)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords高血圧 / モデルラット / 遺伝 / 高血圧学 / 遺伝解析
Research Abstract

The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetic model rat for essential hypertension. We previously identified that a region of chromosome 1 harbored a gene (or genes) responsible for exaggerated stress response in SHRSP. In the present study, we narrowed down the region to 1.2 Mbp and found a strong candidate gene that had a truncation in SHRSP.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (46 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (34 results) Book (2 results)

  • [Journal Article] Two genomic regions of chromosome 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rat/Izm.2013

    • Author(s)
      Gandolgor TA, Cui ZH, Nabika T(他 7名)
    • Journal Title

      Hypertension

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: With a systematic review of recent articles.2012

    • Author(s)
      Yao H, Nabika T.
    • Journal Title

      J Transl Med

      Volume: 6(10) Issue: 1 Pages: 139-139

    • DOI

      10.1186/1479-5876-10-139

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The stroke-prone spontaneously hypertensive rat: Still a useful model for post-GWAS genetic studies?2012

    • Author(s)
      Nabika T
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 5 Pages: 477

    • DOI

      10.1038/hr.2012.30

    • NAID

      10030645486

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hydrogen-rich water on abnormalities in a SHR.Cg -Leprcp/NDmcr rat - a metabolic syndrome rat model.2011

    • Author(s)
      Hashimoto M, Nabika T (他 5名)
    • Journal Title

      Med Gas Res

      Volume: 3(1)1 Issue: 1 Pages: 26-26

    • DOI

      10.1186/2045-9912-1-26

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat.2011

    • Author(s)
      Xiao B, Harada Y, Kawakami K, Nabika T.
    • Journal Title

      J Hypertens

      Volume: 29 Issue: 2 Pages: 257-65

    • DOI

      10.1097/hjh.0b013e32834137cd

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing photothrombotic distal middle cerebral artery occlusion and YAG laser-induced reperfusion model in the Izumo strain of spontaneously hypertensive rats.2011

    • Author(s)
      Yao H, Nabika T.
    • Journal Title

      Cell Mol Neurobiol

      Volume: 31 Issue: 1 Pages: 57-63

    • DOI

      10.1007/s10571-010-9553-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing Photothrombotic Distal Middle Cerebral Artery Occlusion and YAG Laser-Induced Reperfusion Model in the Izumo Strain of Spontaneously Hypertensive Rats.2011

    • Author(s)
      Yao H, Nabika T
    • Journal Title

      Cellular and molecular neurobiology

      Volume: 31 Pages: 57-63

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood pressure-independent factors determine the susceptibility to delayed neuronal death in the stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Sakurai-Yamashita Y, Nabika T, Niwa M.
    • Journal Title

      Cell Mol Neurobiol

      Volume: 30 Issue: 2 Pages: 283-7

    • DOI

      10.1007/s10571-009-9450-y

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress : evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat.2010

    • Author(s)
      Xiao B, Harada Y, Kawakami K, Nabika T
    • Journal Title

      Journal of hypertension

      Volume: 29 Pages: 257-265

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood pressure-independent factors determine the susceptibility to delayed neuronal death in the stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Sakurai-Yamashita Y, Nabika T, Niwa M.
    • Journal Title

      Cellular and molecular neurobiology

      Volume: 30 Pages: 283-287

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝的モデルラット SHRSP を用いた高血圧,脳卒中遺伝子の探索2012

    • Author(s)
      並河 徹
    • Organizer
      第58回日本病理学会秋期特別総会
    • Place of Presentation
      ウインクあいち(名古屋市)
    • Year and Date
      2012-11-22
    • Related Report
      2012 Final Research Report
  • [Presentation] The prospect for animal research in Japan-Disease models beyond SHR ~ . Cardiovascular Genetics Symposium2012.2012

    • Author(s)
      Nabika T
    • Organizer
      15th International SHR Symposium 48th Japanese SHR SHR Meeting
    • Place of Presentation
      Melbourne Brain Cnter.Melbourne(Australia)
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Search for the genes responsible for exaggerated sympathetic response to stress in SHRSP: genetic and molecular biological approach using congenic strains. Cardiovascular Genetics Symposium20122012

    • Author(s)
      Ohara H, Ferdaus Zubaerul Mohammed, Isomura M, Nabika T
    • Organizer
      15th International SHR Symposium 48th Japanese SHR SHR Meeting
    • Place of Presentation
      Melbourne Brain Cnter. Melbourne(Australia)
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 食塩前負荷により中大脳動脈閉塞による脳梗塞は血圧変動を伴わずに増大する:高血圧自然発症ラットとダブルコンジェニックラットを用いた検討2012

    • Author(s)
      八尾 博史, 並河 徹
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル(名古屋市)
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] SHRSP の遺伝的脳卒中感受性の殆どは2つの染色体領域で決定される2012

    • Author(s)
      並河 徹, 大原 浩貴
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル(名古屋市)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] ストレス感受性から見た SHRSP における高血圧原因遺伝子の探索2012

    • Author(s)
      大原浩貴,並河 徹
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル (名古屋市)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Further Refinement of the Quantitative Trait Locus Regulating Symapathetic Response in the Stroke-Prone Spontaneously Hypertensive Rat2012

    • Author(s)
      Xiao B, Ohara H, Zubaerul F, Kawakami K, Isomura M, Nabika T
    • Organizer
      22nd European Meeting on Hyertension and cardiovascular Protection
    • Place of Presentation
      ExCeL London. London(England)
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Further Refinement of the Quantitative Trait Locus Regulating Symapathetic Response in the Stroke-Prone Spontaneously Hypertensive Rat.2012

    • Author(s)
      Xiao B
    • Organizer
      22nd European Meeting on Hyertension and cardiovascular Protection.
    • Place of Presentation
      ロンドン(イギリス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The prospect for animal research in Japan-Disease models beyond SHR~2012

    • Author(s)
      Nabika T
    • Organizer
      Cardiovascular Genetics Symposium2012. 15th International SHR Symposium 48th Japanese SHR SHR Meeting.
    • Place of Presentation
      メルボルン(オーストラリア)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Search for the genes responsible for exaggerated sympathetic response to stress in SHRSP: genetic and molecular biological approach using congenic strains.2012

    • Author(s)
      Ohara H
    • Organizer
      Cardiovascular Genetics Symposium2012. 15th International SHR Symposium 48th Japanese SHR SHR Meeting
    • Place of Presentation
      メルボルン(オーストラリア)
    • Related Report
      2012 Annual Research Report
  • [Presentation] SHRSPの遺伝的脳卒中感受性の殆どは2つの染色体領域で決定される2012

    • Author(s)
      並河 徹
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ストレス感受性から見たSHRSPにおける高血圧原因遺伝子の探索2012

    • Author(s)
      大原浩貴
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食塩前負荷により中大脳動脈閉塞による脳梗塞は血圧変動を伴わずに増大する:高血圧自然発症ラットとダブルコンジェニックラットを用いた検討2012

    • Author(s)
      八尾 博史
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 遺伝的モデルラットSHRSPを用いた高血圧,脳卒中遺伝子の探索2012

    • Author(s)
      並河 徹
    • Organizer
      第58回日本病理学会秋期特別総会
    • Place of Presentation
      ウィンクあいち(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] SHRSP の脳卒中感受性は 2 つの染色体領域に起因する:doublecongenic 系統での検討2011

    • Author(s)
      大原浩貴,並河 徹
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      栃木県総合文化センター(宇都宮市)
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] SHRSPの脳卒中感受性は2つの染色体領域に起因する:double congenic系統での検討2011

    • Author(s)
      大原浩貴, 並河徹
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      栃木県総合文化センター(宇都宮市)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 第1,18 染色体上の QTL はSHRSP の脳卒中感受性の大部分を説明する2011

    • Author(s)
      小川淑子,ツェンデアユーシ ガンドルゴル,大原浩貴,島田大輝,川上浩平, 崔 宗虎,並河 徹
    • Organizer
      第47回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Further refinement of the QTL regulating sympathetic stress-response in SHRSP2011

    • Author(s)
      Ferdaus MZ, Xiao B, Ohara H, Kawakami K, Nabika T
    • Organizer
      第47回高血圧関連疾患モデル学会総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 第1,18染色体上のQTLはSHRSPの脳卒中感受性の大部分を説明する2011

    • Author(s)
      小川淑子, 並河徹, 他5名
    • Organizer
      第47回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遺伝解析に基づく新たなモデルラット作成: congenic strategy からの展開2011

    • Author(s)
      並河 徹 , 崔 宗虎 ,小川淑子,Tsend-Ayush Gandolgor, 島田大輝,川上浩平,大原浩貴,磯村 実
    • Organizer
      第47回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2011-09-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 遺伝解析に基づく新たなモデルラット作成:congenic strategyからの展開2011

    • Author(s)
      並河徹, 他7名
    • Organizer
      第47回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      北海道大学(札幌市)(招待講演)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synergic Efefect of Two Qtls onchromosome 1 and 18 Accounts for the Difference of StrokeSusceptibility Between SHR and SHRSP; A Sutudy on Double-Congenic Strains2011

    • Author(s)
      Nabika T, Cui ZH, Ogawa T, Gandolgor TA, Kawakami K, Ohara H
    • Organizer
      21st European Meeting on Hypertension and Cardiovascular Prevention
    • Place of Presentation
      MICO Milano Congressi. Milano(Italy)
    • Year and Date
      2011-06-18
    • Related Report
      2012 Final Research Report
  • [Presentation] SHRSP由来の第1、18 染色体領域は相乗的に SHR の脳卒中感受性を亢進させる2011

    • Author(s)
      ツェンデアユーシ ガンドルゴル,小川淑子,大原浩貴, 崔 宗虎, 並河 徹
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2011-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] SHRSP由来の第1、18染色体領域は相乗的にSHRの脳卒中感受性を亢進させる2011

    • Author(s)
      ツェンデアユーシ ガンドルゴル, 並河徹, 他3名
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船掘(東京都)
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of a 1.8-Mbp genomic fragment on chromosome 1 on sympathetic response to stressors : Evalution in reciprocal congenic strains between SHRSP and WKY.2010

    • Author(s)
      Xiao B, Nabika T
    • Organizer
      The X VIIIth International Workshop on Genetic Systems in the Rat.
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of a 1.8-Mbp genomic fragment on chromosome 1 on sympathetic response to stressors: Evalution in reciprocal congenic strains between SHRSP and WKY2010

    • Author(s)
      Xiao B, Nabika T
    • Organizer
      The X VIII th International Workshop on Genetic Systems in the Rat
    • Place of Presentation
      京都大学(京都市)
    • Year and Date
      2010-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Synergic effect of two QTLs on chromosome 1 and 18 accounts for the difference of stroke-susceptibility between SHR and SHRSP; A study on a double-congenic strain2010

    • Author(s)
      Cui ZH, Ogawa T, Gandolgor T-A, Xiao B, Kawakami K, Nabika T
    • Organizer
      The XVIII th International Workshop on Genetic Systems in the Rat
    • Place of Presentation
      京都大学(京都市)
    • Year and Date
      2010-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Synergic effect of two QTLs on chromosome 1 and 18 accounts for the difference of stroke-susceptibility between SHR and SHRSP ; A study on a double-congenic strain.2010

    • Author(s)
      Cui ZH, Ozawa T, Gandolgor T-A, Xiao B, Kawakami K, Nabika T
    • Organizer
      The X VIIIth International Workshop on Genetic Systems in the Rat.
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット第1 染色体上の 1.5Mbpの領域が SHRSP のストレス反応性に関与する2010

    • Author(s)
      並河 徹
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2010-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of a small genomic fragment on chromosome 1 on sympathetic response to stressors: Evaluation in reciprocal congenic strains between SHRSP and WKY2010

    • Author(s)
      Xiao B, Nabika T
    • Organizer
      6th International ISP Congress and 14th International SHR Sympsium
    • Place of Presentation
      Palais des Congres. Montreal(Canada)
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of a small genomic fragment on chromosome 1 on sympathetic response to stressors : Evaluation in reciprocal congenic strains between SHRSP and WKY.2010

    • Author(s)
      Xiao B, Nabika T
    • Organizer
      6^<th> International ISP Congress and 14^<th> International SHR Sympsium.
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of the plasma ARG/ADMA ratio with the salt-sensitivity2010

    • Author(s)
      Nabika T, Yasui N, Notsu Y, Njelekela M, Nara Y, Yamori Y, Ikeda K
    • Organizer
      20th European Meeting on Hypertension
    • Place of Presentation
      Norway Exhibition & Convention Center. Oslo(Norway)
    • Year and Date
      2010-06-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of small genomic fagment on chromosome 1 on the sympathetic reavtivity to stresses: Evaluation in the reciprocal cogenic strains between WKY and SHRSP2010

    • Author(s)
      Xiao B, Nabika T
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] SHRSP/Izm とSHR/Izm のコンジェニックラットによる脳卒中関連遺伝子の探索

    • Author(s)
      崔 宗虎 , 並河 徹
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都テルサ (京都市)
    • Related Report
      2012 Final Research Report
  • [Book] Standards and pitfalls regarding the SHR model in genetic hypertension and stroke. In: Hypertension, Heredity and Stroke eds2010

    • Author(s)
      Yao H, Nabika T
    • Publisher
      Moratinos C, Cardenas B, Nova Science
    • Related Report
      2012 Final Research Report
  • [Book] 循環器疾患2010

    • Author(s)
      並河 徹
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi