| Project/Area Number |
22590912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
OKURA Takafumi 愛媛大学, 大学院・医学系研究科, 准教授 (40260385)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYOSHI Ken-ichi 愛媛大学, 大学院・医学系研究科, 助教 (50423439)
IRITA Jun 愛媛大学, 医学部附属病院, 助教 (00423442)
JHOTOKU Masanori 愛媛大学, 医学部附属病院, 医員 (10452690)
NAGAO Tomoaki 愛媛大学, 医学部附属病院, 医員 (20512164)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Interleukin-18 / オステオポンチン / アルドステロン / 腎線維化 / 高血圧 / 尿細管細胞 / インターロイキン18 / 慢性腎臓病 / タイプIコラーゲン / フイブロネクチン / 腎尿細管細胞 |
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| Research Abstract |
We evaluated the effects of IL-18 which is a pro-inflammatory cytokine on kidney injury by aldosterone. Wild type or IL-18 knock out (KO) mouse were unilateral nephrectomized and treated with high salt and aldosterone. In wild type mouse, glomerular hypertrophy, mesangial matrix expansion and interstitial fibrosis were observed. On the other hand, in IL-18 KO mouse, these changes were diminished. In wild type mouse, osteopontin (OPN) was up-regulated but not in KO mouse. These results suggested that aldosterone induced renal fibrosis by induction of IL-18 and OPN.
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