Mechanisms for crosstalk between kidney and heart on diabeticmicroangiopathy: roles of the kidney as an organ of Na homeostasis

• Project/Area Number: 22590914
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Jichi Medical University
• Principal Investigator: MUTO Shigeaki 自治医科大学, 医学部, 教授 (40190855)
• Co-Investigator(Kenkyū-buntansha): MASUDA Takahiro 自治医科大学, 医学部, 助教 (10424037)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糖尿病 / 心臓微小血管障害 / 腎臓微小血管障害 / 組織アンジオテンシンII / 腎臓Na輸送 / 容量負荷 / 心腎連関 / 糖尿病性腎症 / 糖尿病性心筋症 / 体液貯留 / Na輸送 / 腎局所アンジオテンシンII / 糸球体過剰濾過 / 尿細管Na再吸収 / 心筋微小血管障害

Research Abstract

In Spontaneously Diabetic Torii rats developing diabeticnephropathy, 1) volume expansion/overload via the stimulatory effect of angiotensin IIoverproduced in proximal tubules on the tubules`Na reabsorption induced angiotensin IIupregulation only in left v

Research Products

• [Journal Article] Heart angiotensin II-inducedcardiomyocyte hypertrophy suppressescoronary angiogenesis and progressesdiabetic cardiomyopathy (2012)
  • Author(s): Masuda T, Muto S, Fujisawa G,Iwazu Y,Kimura M, Kobayashi T, Nonaka-SarukawaM, Sasaki N, Watanabe Y,Shinohara M,Murakami T,Shimada K,Kobayashi E,KusanoE
  • Journal Title: Am. J. Physiol.Heart Circ. Physiol Volume: 302
  • Peer Reviewed
• [Journal Article] Heart angiotensin II-induced cardiomyocyte hypertrophy suppresses coronary angiogenesis and progress es diabetic cardiomyopathy (2012)
  • Author(s): Takahiro Masuda
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 302 Issue: 9 Pages: H1871-H1883
  • DOI: 10.1152/ajpheart.00663.2011
  • Peer Reviewed
• [Presentation] Crosstalk between kidney and heart angiotensin II contributes to diabetic cardiomyopathy through volume expansion and over-load (2011)
  • Author(s): Takahiro Masuda
  • Organizer: The 44th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: 米国、Philadelphia、Pennsylvania Convention Center
  • Year and Date: 2011-11-11
• [Presentation] Crosstalkbetween kidney and heart angiotensin IIcontributes to diabetic cardiomyopathythrough volume expansion and overload (2011)
  • Author(s): Masuda T,Muto S,Kusano E:
  • Organizer: The 44th Annual Meeting of the AmericanSociety of Nephrology
  • Place of Presentation: Philadelphia, PA, USA
• [Presentation] 心・腎局所アンジオテンシンIIと糖尿病性心筋障害」 (2010)
  • Author(s): 増田貴博、武藤重明、草野英二
  • Organizer: 第40回日本腎臓学会東部学術総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2010-09-25
• [Presentation] 心・腎局所アンジオテンシンIIと糖尿病性心筋障害 (2010)
  • Author(s): 増田貴博
  • Organizer: 第40回日本腎臓学会東部学術総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2010-09-25
• [Presentation] 糖尿病性腎症の体液貯留における腎臓局所Angiotensin IIの関与:SpontaneouslyDiabetic Torii(SDT)ratを用いた検討。 (2010)
  • Author(s): 増田貴博、武藤重明、篠原雅巳、草野英二
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸