Roles of novel NADPH oxidase regulater, Poldip2, in renal pahophysiology
| Project/Area Number |
22590918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | NADPHオキシダーゼ / TGF-β / 糖尿病性腎症 / poldip2 / Poldip2 / 高血圧性腎症 / メサンジウム細胞 / I型コラーゲン / 高血圧性腎障害 / 皮質集合管 |
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| Research Abstract |
Podip2, a regulator for NADPH oxidase, is localized to glomerular cells, and epithelium of cortical and modularly collecting ducts. Its expression is upregulated in a diabetic animal model according to age. Contrary, it is downregulated in a hypertensive animal model. Transforming growth factor-β stimulates its expression in a cell culture system.
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Report
(4 results)
Research Products
(5 results)
