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Roles of novel NADPH oxidase regulater, Poldip2, in renal pahophysiology

Research Project

Project/Area Number 22590918
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKinki University

Principal Investigator

TANIYAMA Yoshihiro  近畿大学, 医学部, 准教授 (70441079)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsNADPHオキシダーゼ / TGF-β / 糖尿病性腎症 / poldip2 / Poldip2 / 高血圧性腎症 / メサンジウム細胞 / I型コラーゲン / 高血圧性腎障害 / 皮質集合管
Research Abstract

Podip2, a regulator for NADPH oxidase, is localized to glomerular cells, and epithelium of cortical and modularly collecting ducts. Its expression is upregulated in a diabetic animal model according to age. Contrary, it is downregulated in a hypertensive animal model. Transforming growth factor-β stimulates its expression in a cell culture system.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010 Other

All Presentation (5 results)

  • [Presentation] NADPH oxidase調節蛋白Poldip2のメサンジウム細胞における役割についての検討2012

    • Author(s)
      中谷嘉寿、谷山佳弘
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] NOX4を制御するNADPH oxidase調節蛋白質Poldip2の糖尿病性腎症に対する検討2011

    • Author(s)
      中谷嘉寿、谷山佳弘
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Poldip2の糖尿病性腎症における病態生理学的意義に関する検討2010

    • Author(s)
      中谷嘉寿、谷山佳弘
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Poldip2の糖尿病性腎症における病態生理的意義に関する検討2010

    • Author(s)
      中谷嘉寿, ほか
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] NADPH oxidase調節蛋白Poldip2のメサンギウム細胞における役割についての検討

    • Author(s)
      中谷 嘉寿
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜 会議センター(横浜)
    • Related Report
      2012 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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