Investigation of klotho protein on protective role of peritoneal membrane
| Project/Area Number |
22590920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
SASAKI Tamaki 川崎医科大学, 医学部, 教授 (30187124)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Minoru 川崎医科大学, 医学部, 講師 (70449891)
FUJIMOTO Sohachi 川崎医科大学, 医学部, 講師 (00319948)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 人工透析学 / Klotho蛋白 / 腹膜線維化 / 腹膜中皮細胞 / Wnt-signal系 / 形質変換 / WNTシグナル / klotho蛋白 |
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| Research Abstract |
The one of obstacles to successful long-term PD is peritoneal fibrosis in peritoneal membrane after exposure to non-physiologic dialysis solutions. Studies have demonstrated that peritoneal mesothelial cells undergoepithelial-to-mesenchymal transition (EMT) after expose to injury. EMT is the important role of the initial peritoneal fibrosis. The induction of EMT is associated with activation of Wnt-dependent beta-catenin signaling and the secreted klotho protein can regulate Wnt signaling. Overexpression of Klotho protein protects the peritoneal membranethrough attenuation of Wnt-signaling.
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Report
(4 results)
Research Products
(20 results)
