11C-Acetate PET imaging for the evaluation of astrocytes in Multiple Sclerosis

• Project/Area Number: 22590931
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Osaka University
• Principal Investigator: NAKATSUJI Yuji 大阪大学, 医学研究科, 講師 (20332744)
• Co-Investigator(Kenkyū-buntansha): TAKATA Kazushiro 大阪大学, 医学部付属病院, 医員 (20573223) ; KINOSHITA Makoto 大阪大学, 医学部付属病院, 医員 (10573222)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アストロサイト / 酢酸 / PET / 多発性硬化症 / NMO

Research Abstract

Astroglial activation in patients with multiple sclerosis (MS) and NMO was evaluated by PET using 11C-acetate as an astrocyte specific radio-ligand. Standardized uptake value (SUV) was significantly increased in the brain of patients with MS compared to healthy volunteer (HV). The SUV of NMO patients was similar to that of HV. These results suggest that 11C-acetate PET can be a useful examination for the evaluation of astrocyte metabolism and for the diagnosis of MS/NMO.

Research Products

• [Journal Article] Disease-Association Analysis of an Inflammation-Related Feedback Loop (2013)
  • Author(s): Murakami M, Nakatsuji Y, Kinoshita M
  • Journal Title: Cell Reports Volume: 3 Pages: 1-14
• [Journal Article] Disease-Association Analysis of an Inflammation-Related Feedback Loop. (2013)
  • Author(s): Murakami M, Harada M, Kamimura D
  • Journal Title: Cell Reports Volume: 3 Issue: 3 Pages: 946-59
  • DOI: 10.1016/j.celrep.2013.01.028
  • Peer Reviewed
• [Journal Article] Review of animal models of neuromyelitis optica (review article) (2012)
  • Author(s): Jones MV, Kinoshita M,Nakatsuji Y, Levy M
  • Journal Title: Mult Scler Relat Disord Volume: 1 Pages: 174-179
• [Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of interferon-β therapy in multiple sclerosis (2012)
  • Author(s): Nakatsuji Y, Okuno T, Moriya M, SugimotoT, Kinoshita M
  • Journal Title: J Immunology Volume: 188 Pages: 4858-4865
• [Journal Article] Where do AQP4 Antibodies Fit in the Pathogenesis of NMO? (2012)
  • Author(s): Kinoshita M, Nakatsuji Y
  • Journal Title: Multiple Sclerosis International
• [Journal Article] Elevation of Sema4A impiicates T helper cell skewing and the efficacy of interferon-β therapy in multiple sclerosis (2012)
  • Author(s): 中辻裕司
  • Journal Title: Journal of Immunology Volume: 188 Issue: 10 Pages: 4858-65
  • DOI: 10.4049/jimmunol.1102023
  • Peer Reviewed
• [Journal Article] Review of animal models of neuromyelitis optica. (2012)
  • Author(s): Melina V.
  • Journal Title: Mult Scler Relat Disord Volume: 1 Pages: 174-179
  • Peer Reviewed
• [Journal Article] Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO? (2012)
  • Author(s): Kinoshita M, Nakatsuji Y
  • Journal Title: Multiple Sclerosis International Volume: (in press) Pages: 1-6
  • DOI: 10.1155/2012/862169
  • Peer Reviewed
• [Journal Article] The role of immune semaphorins in multiple sclerosis (2011)
  • Author(s): Okuno T, Nakatsuji Y, Kumanogoh A
  • Journal Title: FEBS Lett Volume: 585 Pages: 3829-35
• [Journal Article] Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis (2011)
  • Author(s): Tada S.
  • Journal Title: Journal of Neuroinflammation Volume: 8 Issue: 1 Pages: 19-29
  • DOI: 10.1186/1742-2094-8-19
  • Peer Reviewed
• [Journal Article] The role of immune semaphorins in multiple sclerosis (2011)
  • Author(s): Okuno T, Nakatsuji Y, Kumanogoh A
  • Journal Title: FEBS Letter Volume: 585(23) Issue: 23 Pages: 3829-3835
  • DOI: 10.1016/j.febslet.2011.03.033
  • Peer Reviewed
• [Journal Article] SNP based analysis of the HLA locus in Japanese multiple sclerosis patients (2011)
  • Author(s): McElroy JP, Isobe N, Gourraud PAFD, Cailler GSJ, Matsushita T, Kohriyama T, Miyamoto K, Nakatsuji Y, Miki T, Hauser SL, Oksenberg JR, Kira J
  • Journal Title: Gene Immunity Volume: 12 Issue: 7 Pages: 523-530
  • DOI: 10.1038/gene.2011.25
  • Peer Reviewed
• [Journal Article] The Lactic Acid Bacterimn Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells (2011)
  • Author(s): Takata K, Kinoshita M, Okuno T, Moriya M, Kohda T, Honorat AJ, Sugimoto T Kumanogoh A, Kayama H, Takeda K, Sakoda S, Nakatsuji Y
  • Journal Title: PLoS ONE Volume: 6(11) Issue: 11 Pages: e27644-e27644
  • DOI: 10.1371/journal.pone.0027644
  • Peer Reviewed
• [Journal Article] Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells (2010)
  • Author(s): Kinoshita M, Nakatsuji Y,Sakoda S
  • Journal Title: Biochem Biophys Res Commun Volume: 394 Pages: 205-210
• [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II (2010)
  • Author(s): Takamatsu H, Nakatsuji Y, (18人中13人目)
  • Journal Title: Nature Immunology Volume: 8(10) Pages: 2408-2413
  • Peer Reviewed
• [Journal Article] Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis (2010)
  • Author(s): Tada S, Nakatsuji Y, (7人中4人目)
  • Journal Title: Journal of Neuroinflammation Volume: (印刷中)
  • Peer Reviewed
• [Presentation] 神経疾患、多発性硬化症の治療標的としての活性酸素種(ROS) (2012)
  • Author(s): 中辻裕司、JA Honorat、木下允、奥野龍禎、 高田和城、甲田亨、多田智、佐古田三郎、望月秀樹
  • Organizer: 第24回日本神経免疫学会
  • Place of Presentation: 長野
• [Presentation] 腸管免疫を利用した多発性硬化症のコントロール (2012)
  • Author(s): 高田和城, JA Honorat, 甲田亨, 木下允, 多田智, 奥野龍禎, 中辻裕司, 佐古田三郎, 望月秀樹
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] 新規神経栄養因子としてのB細胞刺激因子（BAFF） (2012)
  • Author(s): 多田 智
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] A xanthine oxidase inhibitor, Febuxostat, ameliorates experimental autoimmune encephalomyelitis (2012)
  • Author(s): Josephe Archie Honorat
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] 神経疾患の治療標的としての活性酸素種（ROS） (2012)
  • Author(s): 中辻裕司
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 長野
• [Presentation] A Xanthine oxidase inhibitor, febuxostat, is effective against EAE (2012)
  • Author(s): Josephe A. Honorat
  • Organizer: 第24回日本神経免疫学会
  • Place of Presentation: 長野
• [Presentation] 腸管免疫を利用した多発性硬化症制御への試み (2012)
  • Author(s): 高田和城
  • Organizer: 第24回日本神経免疫学会
  • Place of Presentation: 長野
• [Presentation] The inhibition of oxidative stress by a xanthine oxidase inhibitor ameliorates EAE (2012)
  • Author(s): Josephe A. Honorat
  • Organizer: The 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
  • Place of Presentation: Lyon, France
• [Presentation] Elevation of Sema4A implicates Th17 skewing and the efficacy of interferon-β therapy in multiple sclerosis (2012)
  • Author(s): Okuno T
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Epiregulin is involved in inflammation development via IL-6 amplifier activation. (2012)
  • Author(s): Harada M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Elevation of Sema4A implicates Th17 skewing and the efficacy of interferon-β therapy in multiple sclerosis (2011)
  • Author(s): Nakatsuji Y, Okuno T, Moriya M, Sugimoto T, Kinoshita M, Takata M, Nakano M, Sakoda S, Kumanogoh A
  • Organizer: The 5th Joint Triennial Congress of the European and Americans Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS)
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-10-20
• [Presentation] he lactic acid bacterium Pediococcus acidilactici suppresses autoimmune ence phalomyelitis by inducing IL-10-producing regulatory T cells (2011)
  • Author(s): Takata K, Kinoshita M, Okuno T, Nakatsuji Y, Sakoda S
  • Organizer: The 5th Joint Triennial Congress of the European and Americans Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS)
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-10-20
• [Presentation] Sema3E promotes migration of Th17 cells during the course of experimental autoumnune encephalitis (2011)
  • Author(s): Okuno T, Nakatsuji Y, Sakoda S, Kumanogoh A
  • Organizer: The 5th Joint Triennial Congress of the European and Americans Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS)
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-10-20
• [Presentation] 血清Sema4A高値は多発性硬化症のTh17偏倚とインターフェロン治療抵抗性を示唆する (2011)
  • Author(s): 中辻裕司、奥野龍禎、森谷真之、杉本知之、木下允、高田和城、中野美佐、佐古田三郎、熊ノ郷淳
  • Organizer: 第23回日本神経免疫学会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2011-09-15
• [Presentation] 腸管免疫を利用した乳酸菌によるEAEの治療 (2011)
  • Author(s): 高田和城、木下允、奥野龍禎、佐古田三郎、中辻裕司
  • Organizer: 第23回日本神経免疫学会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2011-09-15
• [Presentation] B細胞刺激因子(BAFF)はALSモデル動物の神経変性を抑制する (2011)
  • Author(s): 多田智、奥野龍禎、安居輝人、中辻裕司、菊谷仁、佐古田三郎
  • Organizer: 第23回日本神経免疫学会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2011-09-15
• [Presentation] Sema3EはEAEにおいてTh17細胞の中枢神経系への移動に関与する (2011)
  • Author(s): 奥野龍禎、中辻裕司、高田和城、木下允、多田智、佐古田三郎、熊ノ郷淳
  • Organizer: 第23回日本神経免疫学会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2011-09-15
• [Presentation] 食事抗原による腸管免疫活性が多発性硬化症のリスクファクターとなる (2011)
  • Author(s): 木下允、高田和城、奥野龍禎、香山尚子、竹田潔、熊ノ郷淳、佐古田三郎、中辻裕司
  • Organizer: 第23回日本神経免疫学会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2011-09-15
• [Presentation] 血清Sema4Aは多発性硬化症(MS)の診断・治療マーカーとして有用である (2011)
  • Author(s): 中辻裕司
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-05-20
• [Presentation] Sema3Eは実験的自己免疫性脳脊髄炎(EAE)においてTh17細胞の中枢神経系への移動に関与する (2011)
  • Author(s): 奥野龍禎、中辻裕司、高田和城、木下允、多田智、佐古田三郎、熊ノ郷淳
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-05-20
• [Presentation] 腸管免疫を利用したEAEの制御 (2011)
  • Author(s): 高田和城、木下允、森谷真之、奥野龍禎、中辻裕司、佐古田三郎
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-05-20
• [Presentation] B細胞刺激因子(BAFF)はALSモデル動物の神経変性を抑制する (2011)
  • Author(s): 多田智、奥野龍禎、安居輝人、中辻裕司、菊谷仁、佐古田三郎
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-05-20
• [Presentation] 脱髄性疾患におけるグリア間およびクリア・ニューロン間相互作用の破綻-MS/NMOのモデルからみた脱髄性疾患における免疫細胞・グリア・ニューロン間相互作用の異常 (2011)
  • Author(s): 中辻裕司
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] Elevation of Sema4A implicates Th17 skewing and the efficacy of interferon-β therapy in multiple sclerosis. 2011.10. The 5th Joint Triennial Congress of the European and Americans Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS (2011)
  • Author(s): Nakatsuji Y, Okuno T, Moriya M, Sugimoto T, Kinoshita M, Takata K, Nakano M, , Sakoda S and Kumanogoh A
  • Organizer: 神経免疫学会
  • Place of Presentation: 東京
• [Presentation] 腸管免疫を利用した乳酸菌による EAE の治療。 (2011)
  • Author(s): 高田和城、木下允、奥野龍禎、佐古田三郎、中辻裕司
  • Organizer: 第23回日本神経免疫学会
  • Place of Presentation: 東京
• [Presentation] 脱髄性疾患におけるグリア間およびグリア・ニューロン間相互作用の破綻-MS/NMO のモデルからみた脱髄性疾患における免疫細胞・グリア・ニューロン間相互作用の異常 (2011)
  • Author(s): 中辻裕司
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 食事抗原による腸管免疫活性が多発性硬化症のリスクファクターとなる (2011)
  • Author(s): 木下允、 高田和城、奥野龍禎、香山尚子、竹田潔、熊ノ郷淳、佐古田三郎、中辻裕司
  • Organizer: 第23回日本神経免疫学会
  • Place of Presentation: 東京
• [Presentation] Sema4A is a serum diagnostic marker of Multiple Sclerosis, which reflects the Th17 shift of PBMC (2010)
  • Author(s): Nakatsuji Y
  • Organizer: The 10th International Congress of Neuroimmunology
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2010-10-29
• [Presentation] Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells (2010)
  • Author(s): Kinoshita M
  • Organizer: The 10th International Congress of Neuroimmunology
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2010-10-29
• [Presentation] Sema4A as a diagnostic marker of multiple sclerosis and its implication in Th17 pathology (2010)
  • Author(s): Nakatsuji Y
  • Organizer: Neuroimmunology Kyoto Conference
  • Place of Presentation: Kyoto(Japan)(招待講演)
  • Year and Date: 2010-08-19
• [Presentation] 多発性硬化症補助診断法としてのSema4A、およびTh17病態との関連 (2010)
  • Author(s): 中辻裕司
  • Organizer: 第51回日本神経学会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] NMO動物モデルにおける抗アクアポリン4抗体病原性の検討 (2010)
  • Author(s): 木下允
  • Organizer: 第51回日本神経学会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells. (2010)
  • Author(s): Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, Kumanogoh A, Kajiyama K, Yoshikawa H, Sakoda S
  • Organizer: The 10th International Congress of Neuroimmunology
  • Place of Presentation: Barcelona, Spain.
• [Presentation] Sema4A is a serum diagnostic marker of Multiple Sclerosis, which reflects the Th17 shift of PBMC. (2010)
  • Author(s): Nakatsuji Y, Okuno T, Moriya M, SugimotoT, Kinoshita M, Nakano M, Kikutani H, Sakoda S, Kumanogoh A.
  • Organizer: The 10th International Congress of Neuroimmunology
  • Place of Presentation: Barcelona, Spain
• [Presentation] NMO 動物モデルにおける抗アクアポリン 4 抗体病原性の検討 (2010)
  • Author(s): 木下允、 中辻裕司、木村 卓、森谷真之、高田和城、奥野龍禎、熊ノ郷淳、梶山孝司、芳川浩男、佐古田三郎
  • Organizer: 第51回日本神経学会
  • Place of Presentation: 東京
• [Book] 実験医学 多発性硬化症とセマフォリン (2013)
  • Author(s): 中辻裕司
  • Total Pages: 6
  • Publisher: 羊土社
• [Book] アクチュアル 脳・神経疾患の臨床 最新アプローチ多発性硬化症と視神経脊髄炎 実験モデルからみた病態 辻省次、吉良潤一編 (2012)
  • Author(s): 中辻裕司、木下允、望月秀樹
  • Publisher: 中山書店
• [Book] NMO の実験的研究の進歩と今後の展望 多発性硬化症(MS)と視神経脊髄炎(NMO)の基礎と臨床 (2012)
  • Author(s): 木下允、中辻裕司
  • Publisher: 医薬ジャーナル社
• [Book] NMOの実験的研究の進歩と今後の展望 多発性硬化症（MS）と視神経脊髄炎（NMO）の基礎と臨床 (2012)
  • Author(s): 木下允
  • Total Pages: 8
  • Publisher: 医薬ジャーナル社
• [Book] アクチュアル 脳・神経疾患の臨床 最新アプローチ 多発性硬化症と視神経脊髄炎 実験モデルからみた病態 (2012)
  • Author(s): 中辻裕司
  • Total Pages: 7
  • Publisher: 中山書店
• [Book] メディカル・テクノロジー 多発性硬化症の治療選択のための検査―セマフォリン４A (2012)
  • Author(s): 中辻裕司
  • Total Pages: 2
  • Publisher: 医歯薬出版株式会社
• [Book] NMO の実験的研究最前線 Brain Medical (2010)
  • Author(s): 木下允、中辻裕司
  • Publisher: メディカルレビュー社
• [Book] NMOの実験的研究最前線 (2010)
  • Author(s): 木下允、中辻裕司
  • Publisher: Brain Medical