Systemic neurodegeneration and involvement of astroglial cells in Parkinson's disease.
| Project/Area Number |
22590934
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Okayama University |
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Principal Investigator |
MIYAZAKI Ikuko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40335633)
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| Co-Investigator(Kenkyū-buntansha) |
ASANUMA Masato 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00273970)
NAKAMURA Kazufumi 岡山大学, 大学病院, 講師 (10335630)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | パーキンソン病 / ロテノン / アストログリア / 末梢神経障害 / 腸管神経叢 / ドパミン神経 / メタロチオネイン / グルタチオン / ドパミン神経細胞 |
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| Research Abstract |
In this study, we revealed that GFAP-positive glial cells were distributed along the myenteric plexus in the ileum and ascending colon of rotenone-chronically treated rats, preceding central dopaminergic neurodegeneration, suggesting possible involvement of enteric glial cells in rotenone-induced cytotoxicity of enteric neuronal cells which precedes neurodegeneration in central nervous system. Using primary cultured cells, we also proposed a possible involvement of some molecules secreted from rotenone-treated mesencephalic astroglia in rotenone-induced dopaminergic neurotoxicity, and revealed that metallothionein could protect dopaminergic neurons against rotenone toxicity.
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression.2013
Author(s)
Sogawa, N., Hirai, K., Sogawa, C., Ohyama, K., Miyazaki, I., Tsukamoto, G., Asanuma, M., Sasaki, A., Kitayama, S.
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Journal Title
Life Sci.
Volume: 92
Pages: 727-732
Related Report
Peer Reviewed
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[Journal Article] Effluent free radicals are associated with residual renal function and predict technique failure in peritoneal dialysis patients.2012
Author(s)
Morinaga, H., Sugiyama, H., Inoue, T., Takiue, K., Kikumoto, Y., Kitagawa, M., Akagi, S., Nakao, K., Maeshima, Y., Miyazaki, I., Asanuma, M., Hiramatsu, M. and Makino, H.
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Journal Title
Perit. Dial. Int.
Volume: 32
Pages: 453-461
Related Report
Peer Reviewed
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[Journal Article] Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity.2012
Author(s)
Asanuma, M., Miyazaki, I., Kikkawa, Y., Kimoto, N., Takeshima, M., Murakami, S., Miyoshi, K.
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Journal Title
Neurochem. Res.
Volume: 37
Pages: 1944-1951
Related Report
Peer Reviewed
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[Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells.2011
Author(s)
Ogawa, D., Asanuma, M., Miyazaki, I., Tachibana, H., Wada, J., Sogawa, N., Sugaya, T., Kitamura, S., Maeshima, Y., Shikata, K. and Makino, F.
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Journal Title
Exp. Diabetes Res.
Volume: 2011
Pages: 534872-534872
Related Report
Peer Reviewed
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[Journal Article] Protective effects of baicalein against excess L-DOPA-induced dopamine quinone neurotoxicity.2011
Author(s)
Takeshima, M., Murata, M., Urasoe, N., Murakami, S., Miyazaki, I., Asanuma, M. and Kita, T.
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Journal Title
Neurol. Res.
Volume: 33
Pages: 1050-1056
Related Report
Peer Reviewed
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[Journal Article] Alpha7 nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine.2011
Author(s)
Ishida, S., Kawasaki, Y., Araki, H., Asanuma, M., Matsunaga, H., Sendo, T., Kawasaki, H., Gomita, Y. and Kitamura, Y.
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Journal Title
Psychopharmacology
Volume: 214
Pages: 923-931
Related Report
Peer Reviewed
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[Journal Article] Chronic treatment with imipramine and lithium increases cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats.2011
Author(s)
Kitamura, Y., Doi, M., Kuwatsuka, K., Onoue, Y., Miyazaki, I., Shinomiya, K., Koyama, T., Sendo, T., Kawasaki, H., Asanuma, M. and Gomita, Y.
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Journal Title
Biol. Pharm. Bull.
Volume: 34
Pages: 77-81
NAID
Related Report
Peer Reviewed
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[Journal Article] Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity2011
Author(s)
Miyazaki, I., Asanuma, M., Kikkawa, Y., Takeshima, M., Murakami, S., Miyoshi, K., Sogawa, N. and Kita, T.
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Journal Title
Glia
Volume: 59
Pages: 435-451
Related Report
Peer Reviewed
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[Journal Article] Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats.2010
Author(s)
Doi, M., Miyazaki, I., Nagamachi, T., Shinomiya, K., Matsunaga, H., Sendo, T., Kawasaki, H., Asanuma, M., Gomita, Y. and Kitamura, Y.
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Journal Title
Acta Med Okayama
Volume: 64
Pages: 219-223
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats.2010
Author(s)
Kitamura, Y., Yagi, T., Kitagawa K., Shinomiya, K., Kawasaki H., Asanuma, M. and Gomita, Y.
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Journal Title
Naunyn-Schmied. Arch. Pharmacol.
Volume: 382
Pages: 151-158
Related Report
Peer Reviewed
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[Journal Article] Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene.2010
Author(s)
Morimoto, N., Nagai, M., Miyazaki, K., Ohta, Y., Kurata, T., Takehisa, Y., Ikeda, Y., Matsuura, T., Asanuma, M. and Abe, K.
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Journal Title
J. Neurosci. Res.
Volume: 88
Pages: 1804-1811
Related Report
Peer Reviewed
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[Journal Article] Neuroprotective effects of zonisamide target astrocyte.2010
Author(s)
Asanuma, M., Miyazaki, I., Diaz-Corrales, F.J., Kimoto, N., Kikkawa, Y., Takeshima, M., Miyoshi, K. and Murata, M.
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Journal Title
Ann. Neurol.
Volume: 67
Pages: 239-249
Related Report
Peer Reviewed
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