Establishment and analysis of novel animal models for neuromyelitis optica using aquaporin-4 knockout mice
Project/Area Number |
22590940
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Keio University |
Principal Investigator |
ABE Yoichiro 慶應義塾大学, 医学部, 講師 (10317331)
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Co-Investigator(Kenkyū-buntansha) |
IKESHIMA Hiroko 慶應義塾大学, 医学部, 特任講師 (60265783)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 神経病態免疫学 / 脳神経疾患 / 免疫学 / 動物モデル / アストロサイト / アクアポリン / 視神経脊髄炎 / 多発性硬化症 |
Research Abstract |
To establish mouse models for neuromyelitis optica, we developed two different kinds of high affinity monoclonal antibodies against the extracellular domains of mouse aquaporin-4 using the baculovirus display method. In addition, to express exogenous gene
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4.2013
Author(s)
Kaori Miyazaki, Yoichiro Abe, Hiroko Iwanari, Yota Suzuki, Takahiro Kikuchi, Takashi Ito, Jungo Kato, Osamu Kusano-Arai, Toshiyuki Takahashi, Shuhei Nishiyama, Hiroko Ikeshima-Kataoka
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Journal Title
J. Neuroimmunol.
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] Development of monoclonal antibodies against the extracellular domains of mouse AQP4 and its application to elucidating the disease mechanism of neuromyelitis optica.2013
Author(s)
A b e , Y., Iwanari, H., Arai, O., Ramadhanti, J., Huang, P., Miyauchi, T., Kurihara, N., Miyazaki, K., Ikeshima-Kataoka, H., Sakihama, T., Hamakubo, T, and Yasui, M.
Organizer
The 86th Annual Meeting of the Japanese Pharmacological Society
Place of Presentation
Fukuoka
Related Report
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