The role of CDK5 activation in neuronal death and angiogenesis after ischemic stroke
Project/Area Number |
22590942
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Nippon Medical School |
Principal Investigator |
NAGATA Chikako (NITO Chikako) 日本医科大学, 医学部, 講師 (30409172)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 局所脳虚血 / Cdk5 / 神経細胞死 / 血液脳関門障害 / 血管新生 |
Research Abstract |
The aim of this study was to clarify the role of Cdk 5 activation in neuronal death and angiogenesis in the brain after transient focal cerebral ischemia (tFCI). After reperfusion, both Cdk5 activation and p25/p35 expression were significantly increased at 6 h compared with the control and decreased the expression at 3 days and recovererd at 7 days as detected by immunoblotting. p25/p35 was significantly upregulated in neurons in the ischemic area at 1 day and also upregulated in microvessels in the ischemic boundary zone from 3 to 7 days after reperfusion. Changes in BBB leakage indicated that BBB breakdown significantly increased 3 days after reperfusion. These findings suggest that Cdk 5 may be related to not only neuronal death but also angiogenesis after tFCI and can be a target for antiangiogenic therapy.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] Combination therapy with edaravone and mild hypothermia prevents MMP-9activiation and neurovascular injury after focal cerebral ischemia in rats2011
Author(s)
Nito C, Ueda M, Inaba T, Okubo S, Nomur K, Kamiya F, Ohta S, Katayama Y
Organizer
The 25th Internal Symposium on Cerebral Blood Flow, Metabolism, and Function
Place of Presentation
Barcelona, Spain
Related Report
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