| Project/Area Number |
22590945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fujita Health University |
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Principal Investigator |
MUTOH Tatsurou 藤田保健衛生大学, 医学部, 教授 (60190857)
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Makoto 名古屋大学, 医学部, 教授 (10187297)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ミクログリア / 情報伝達 / チロシンリン酸化 / 中性糖脂質 / 脂質ラフト / GlcCer / GlcT-1 / β-glucosidase / microglia / cytokine / neurotrophin / real time PCR / neutral glycosphingolipid / glucosylceramide / lactosylceramide / lipid rafts / Parkinson病 / 神経免疫疾患 / 糖鎖生物学 / 糖脂質 |
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| Research Abstract |
Recent advances on the understanding of microglia have revealed that microglia plays important roles on the development and propagation of neurological disorders, which are recruited to the lesions of the brain. What are these recruited microglia doing on the lesions of central nervous system? Previous reports including ours have demonstrated that there are two different microglia, one is acting as neuroprotective roles and other as neurotoxic roles on neurons. At present, however, the molecular mechanisms for two different phenotypes of microglia remain to be elucidated. In this study, we tried to characterize these cells from the neuro-glycobiological point of view and found that there is an obvious difference of the contents of neutral glycosphingolipids. These differences of neutral glycosphingolipid contents seem to determine their biological and immunological property.
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