| Project/Area Number |
22590947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Tatsuo 福岡大学, 医学部, 教授 (50142211)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 家族制パーキンソン病 / ダイナクチン / Perry 症候群 / TDP-43 / 家族性パーキンソン病 / Perry症候群 / TDP－43 / パーキンソン病 / ダイナクチン遺伝子 |
|---|
| Research Abstract |
Perry syndrome is characterized by autosomal dominant parkinsonism with mental depression, weight loss and central hypoventilation. It has been thought to be rare disorder, however, after our first report from Japan in 2002, newly discovered families with this syndrome has been discovered throughout the world. DCTN1 gene is identified as a causative gene for Perry syndrome in 2009. Our purpose is to characterize this syndrome clinically and pathologically, in addition, to analyze function andpathogenesis of DCTN1 as a Parkinson disease related gene.
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