| Project/Area Number |
22590952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Hirosaki University |
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Principal Investigator |
TOMIYAMA Masahiko 弘前大学, 医学(系)研究科(研究院), 研究員 (40311542)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Akira 弘前大学, 医学(系)研究科(研究院), 研究員 (80422062)
SUGIMOTO Kazuhiro 弘前大学, 大学院・医学研究科, 准教授 (70271799)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | パーキンソン病 / リン酸化αシヌクレイン / Lewy neurite / 多系統萎縮症 / 皮膚生検 / L-ドパ / 表皮内神経密度 / 早期パーキンソン病 / L－ドパ / 皮膚 / 生検 / αシヌクレイン / 自律神経 / 末梢神経 |
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| Research Abstract |
Lewy pathology in biopsied skin was found only in three of 37 patients with Parkinson disease (PD). Clinical availability of skin biopsy was limited for the diagnosis of Parkinson disease.No Lewy pathology was detected in biopsied skin from patients with multipe system atrophy (MSA). Intraepidermal nerve density (IENF) was significantly lower in patients with PD than in MSA. No significant differences in IENF were found between L-DOPA-treated and drug-naive patients with PD. The decrease in IENF did not result from L-DOPA treatment. This result suggests that the evaluation of IENF is useful to differentiate PD from MSA
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