| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Deep brain stimulation (DBS) of the basal ganglia has come to be widely used for the treatment of Parkinson’s disease (PD). However, the exact mechanism of action at the systems level as well as its effect on cognition is largely unknown. The goal of the present study was to elucidate the mechanism of DBS of STN and other targets on cognitive function. In the first part of experiments, we devised cognitive tasks including temporal processing and visual search tasks to study the cognitive efficiency of PD patients With the STN DBS switched on and off, PD patients also performed a visual search task in which subjects had to find a target from among an array of distractors. DBS not only improved the efficiency of visual search but also the saccade amplitudes during the task. The cognitive tasks used proved useful for evaluating the cognitive functions in PD patients undergoing pre-surgical assessment. The effect of GPi DBS on saccade parameters was relatively small, although it had a significant effect on motor symptoms of PD, in contrast to subthalamic DBS improving the amplitudes of saccades in all tasks studied, suggesting that the mechanisms of actions of STN DBS and GPi DBS were different. Using the cognitive tasks in combination with the clinical assessment of the effect of DBS would not only provide insights into the mechanism of cognitive impairment induced by DBS but also be helpful for selecting targets for DBS.
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