| Project/Area Number |
22590955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
ITO Mizuki 名古屋大学, 医学系研究科, 特任助教 (50437042)
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| Co-Investigator(Kenkyū-buntansha) |
SOBUE Gen 名古屋大学, 医学系研究科, 教授 (20148315)
WATANBE Hirohisa 名古屋大学, 医学部附属病院, 講師 (10378177)
ATSUTA Naoki 名古屋大学, 医学部附属病院, 助教 (90547457)
SENDA Jo 名古屋大学, 医学部附属病院, 医員 (80569781)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 多系統萎縮症 / バイオマーカー / voxel-based morphometry / mean diffusivity / fractional anisotropy / fractional anisotorpy / 多系統萎縮症(MSA) / volumetry / fractional anisotropy(FA) / mean diffusivity(MD) |
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| Research Abstract |
To assess the progression of brain degeneration in patients with multiple system atrophy (MSA), we conducted prospective analyses using voxel-based morphometry (VBM), mean diffusivity (MD), and fractional anisotropy (FA) of magnetic resonance imaging. We evaluated VBM, MD and FA in 17 probable MSA patients every 6 months from registration for 2 years, and compared their findings to those of 17 healthy controls using a voxel-based analysis technique. VBM, MD and FA showed the progressive spread of cerebral degeneration mainly in the frontal lobe, especially the prefrontal cortex, subsequently spreading to the temporal and parietal lobes, and finally to the occipital lobe after 2 years. VBM, FA, and MD showed the distinct progression pattern of cerebral involvement in MSA. The simultaneous evaluation of VBM, FA, andMD can provide an insight into the features of cerebral abnormalities in MSA and potential quantitative biomarkers of disease progression.
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