Development of new therapies for vascular dementia
| Project/Area Number |
22590958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kagawa University |
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Principal Investigator |
UENO Masaki 香川大学, 医学部, 准教授 (30322267)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Haruhiko 香川大学, 医学部, 教授 (60106549)
黄 政龍 公益財団法人田附興風会, 医学研究所第一研究部, 研究主幹 (10271511)
小野寺 正征 香川大学, 医学部, 助教 (40359922)
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| Co-Investigator(Renkei-kenkyūsha) |
KOH Seiryu 公益財団法人田附興風会, 医学研究所第一研究部, 研究主幹
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 臨床神経形態学 / 血管性認知症 / オステオポンチン / CD36 / 血管脳関門 / Glut5 / 血液脳関門 |
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| Research Abstract |
The expression of osteopontin, CD36, and LDL receptor (LDLR) was turned out to be increased in vessels showing blood-brain barrier (BBB) dysfunction. We could productsynthetic peptides of osteopontin, an antibody for osteopontin, virus vector expressing osteopontin. The expression of CD36 was turned out to be increased in the vessels showing BBB dysfunction in brains of hypertensive rats and senescence accelerated mice. Drugs inducing the reduction of CD36 or LDLR expression may be useful for the therapy against vascular dementia. In addition, angiotensin receptor blockers (ARBs) reduced vascular damage including the BBB damage, suggesting that the usage of ARBs with osteopontin may be effective for the therapy against vascular dementia.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Cerebral blood volume combined with amplitude-integrated EEG can be a suitable guide to control hypoxic/ischemic insult in a piglet model2012
Author(s)
Nakamura S, Kusaka T, Yasuda S, Ueno M, Miki T, Koyano K, Nakamura M, Okada H, Okazaki K, Isobe K, Itoh S.
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Journal Title
Brain Dev
Volume: (in press)
URL
Related Report
Peer Reviewed
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[Journal Article] Blockage of AT1 receptors protects the blood-brain barrier and improve cognition in Dahl salt-sensitive hypertensive rats.2011
Author(s)
Pelish N, Hosomi N, Ueno M, Nakano D, Hitomi H, Mogi M, Shimada K, Kobori H, Horiuchi M, Sakamoto H, Matsumoto M, Kohno M, Nishiyama A.
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Journal Title
Am J Hypertens
Volume: 24
Issue: 3
Pages: 362-368
DOI
Related Report
Peer Reviewed
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[Journal Article] The expression of CD36 in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model.2011
Author(s)
Ueno M, Nakagawa T, Nagai Y, Nishi N, Kusaka T, Kanenishi K, Onodera M, Hosomi N, Huang C, Yokimise H, Tomimoto H, Sakamoto H.
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Journal Title
Neuropathology and Applied Neurobiology
Volume: 37
Issue: 7
Pages: 727-737
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia.2011
Author(s)
Fu H, Hosomi N, Pelish N, Nakano D, Liu G, Ueno M, Miki T, Masagata H, Sueda Y, Itano T, Matsumoto M, Nishiyama A, Kohno M
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Journal Title
J Hypertens
Volume: 29
Issue: 11
Pages: 2210-2219
DOI
Related Report
Peer Reviewed
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