• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of SPECT-based objective evaluating system for therapeutic effect of acute revascularization therapy

Research Project

Project/Area Number 22590959
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionOita University (2012)
Kumamoto University (2010-2011)

Principal Investigator

HIRANO Teruyuki  大分大学, 医学部, 准教授 (50346996)

Co-Investigator(Kenkyū-buntansha) WATANABE Masaki  熊本大学, 医学部附属病院, 助教 (40530150)
UCHINO Makoto  元熊本大学, 大学院・生命科学研究部, 教授 (20117336)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords神経機能学 / 血行再建療法 / 脳梗塞 / 急性期治療 / 脳血流SPECT / 血行再建 / 血管内治療
Research Abstract

Since 2011, endovascular therapies using thrombectomy devices are increasingly performed among patients with acute ischemic stroke in whom alteplase failed to recanalize or contraindicated. It is difficult to prove its efficacy by randomiz ed controlled therapy, however, as they require skilled endovascular speciallists. Thus, we developed a SPECT -based objective evaluating system by comparing predicted infarct volume on residual CBF and final infarct volume.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2013 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 7 results) Presentation (17 results) (of which Invited: 1 results) Book (7 results) Remarks (1 results)

  • [Journal Article] Secondary signal change and an apparent diffusion coefficient decrease of the substantia nigra following striatal infarction2013

    • Author(s)
      Nakajima M, Inatomi Y, Okigawa T, Yonehara T, Hirano T
    • Journal Title

      Stroke

      Volume: vol.44 Issue: 1 Pages: 213-216

    • DOI

      10.1161/strokeaha.112.673020

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 超急性期治療体制整備の意義2013

    • Author(s)
      平野照之
    • Journal Title

      最新医学

      Volume: vol 68 Pages: 936-943

    • Related Report
      2012 Final Research Report
  • [Journal Article] 脳卒中超急性期-画像でどこまでわかる2013

    • Author(s)
      平野照之
    • Journal Title

      内科

      Volume: vol 111 Pages: 843-848

    • Related Report
      2012 Final Research Report
  • [Journal Article] 治療戦略を決めるうえでのSPECT の意義2013

    • Author(s)
      平野照之
    • Journal Title

      Medicina

      Volume: vol 50 Pages: 236-240

    • Related Report
      2012 Final Research Report
  • [Journal Article] Low ASPECTS within 3 hours of onset predicts subsequent sICH in patients treated with 0.6 mg/kg alteplase2012

    • Author(s)
      Hirano T, Sasaki M, Tomura N, Ito Y, Kobayashi S
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: vol 21 Issue: 8 Pages: 898-902

    • DOI

      10.1016/j.jstrokecerebrovasdis.2011.05.018

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 6-Fr guiding catheter (Slim Guide(®)) for use with multiple microdevices.2012

    • Author(s)
      Kai Y, Ohmori Y, Watanabe M, Kaku Y, Morioka M, Hirano T, Yano S, Kawano T, Hamada J, Kuratsu J.
    • Journal Title

      Surg Neurol Int

      Volume: 3 Issue: 1 Pages: 59-59

    • DOI

      10.4103/2152-7806.97003

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissecting aneurysms of the vertebral artery--angiographic patterns at the dissecting site on balloon test occlusion.2012

    • Author(s)
      Kai Y, Hamada J, Morioka M, Ohmori Y, Watanabe M, Hirano T, Kawano T, Yano S, Kuratsu J.
    • Journal Title

      Neuroradiology

      Volume: 54(8) Issue: 8 Pages: 857-62

    • DOI

      10.1007/s00234-011-0993-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] rt-PA (アルテプラーゼ)静注療法適正治療指針2012

    • Author(s)
      峰松一夫, 中川原譲二, 森 悦朗, 近藤礼, 棚橋紀夫, 塩川芳昭, 坂井信幸, 木村和美, 平野照之, 豊田一則, 小川彰, 山口武典, 佐々木真理, 菅 貞郎, 片山泰朗, 宮本 享
    • Journal Title

      第二版.脳卒中

      Volume: vol 34 Pages: 443-480

    • Related Report
      2012 Final Research Report
  • [Journal Article] Modified ASPECTS for DWI including deep white matter lesions predicts subsequent intra- cranial hemorrhage2012

    • Author(s)
      Kawano H, Hirano T, Nakajima M, Inatomi Y, Yonehara T, Uchino M
    • Journal Title

      J Neurol

      Volume: vol.259 Issue: 10 Pages: 2045-2052

    • DOI

      10.1007/s00415-012-6446-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳血管障害の地域医療2012

    • Author(s)
      平野照之
    • Journal Title

      神経治療学

      Volume: vol 29 Pages: 713-720

    • Related Report
      2012 Final Research Report
  • [Journal Article] rt-PA 静注療法の現状と問題点2012

    • Author(s)
      平野照之
    • Journal Title

      カレントテラピー

      Volume: vol 30 Pages: 1108-1112

    • Related Report
      2012 Final Research Report
  • [Journal Article] 超急性期に求められる画像診断2012

    • Author(s)
      平野照之
    • Journal Title

      循環器内科

      Volume: vol 72 Pages: 266-274

    • Related Report
      2012 Final Research Report
  • [Journal Article] 急性期血行再建療法の最新動向2012

    • Author(s)
      平野照之
    • Journal Title

      リハ医学

      Volume: vol 49 Pages: 375-378

    • Related Report
      2012 Final Research Report
  • [Journal Article] 急性期脳梗塞における早期CT サインの重要性2011

    • Author(s)
      平野照之
    • Journal Title

      MB Med Reha

      Volume: vol 132 Pages: 39-45

    • Related Report
      2012 Final Research Report
  • [Journal Article] 急性期虚血性脳卒中に関する画像診断2011

    • Author(s)
      平野照之
    • Journal Title

      脳と循環

      Volume: vol 16 Pages: 163-172

    • Related Report
      2012 Final Research Report
  • [Journal Article] Residual vessel length on magnetic resonance angiography identifies poor responders in acute middle cerebral artery occlusion patients: Exploratory analysis of J-ACT II2010

    • Author(s)
      Hirano T, Sasaki M, Mori E, Minematsu K, Nakagawara J, Yamaguchi T
    • Journal Title

      Stroke

      Volume: vol 41 Issue: 12 Pages: 2828-2833

    • DOI

      10.1161/strokeaha.110.594333

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of 0.6 mg/kg intravenous alteplase on vascular and clinical outcomes in middle cerebral artery occlusion. Japan Alteplase Clinical Trial II (J-ACT II)2010

    • Author(s)
      Mori E, Minematsu K, Nakagawara J, Yamaguchi T, Sasaki M, Hirano T
    • Journal Title

      Stroke

      Volume: vol 41 Issue: 3 Pages: 461-465

    • DOI

      10.1161/strokeaha.109.573477

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain Attack の画像診断最近の進歩2010

    • Author(s)
      平野照之
    • Journal Title

      プラクティス

      Volume: vol 27 Pages: 507-515

    • Related Report
      2012 Final Research Report
  • [Presentation] Initial NIHSS and age are major predictors for acute symptom progression. Exploratory analysis of the PENTAGON study2013

    • Author(s)
      Hirano T, Yonehara T, Terasaki T, Takita T, Hashimoto Y
    • Organizer
      International Stroke Conference 2013
    • Place of Presentation
      Honolulu
    • Related Report
      2012 Final Research Report
  • [Presentation] Initial NIHSS and age major predictors for acute symptom progression. Exploratory analusys of the PENTAGON study.2013

    • Author(s)
      Hirano T, Yonehara T, Terasaki T, Takita T, Hashimoto Y
    • Organizer
      International Stroke Conference 2013
    • Place of Presentation
      Honolulu
    • Related Report
      2012 Annual Research Report
  • [Presentation] シロスタゾールとアスピリンの進行型脳梗塞に関する前向き共同臨床比較試験(第2報)2012

    • Author(s)
      平野照之, 米原敏郎, 寺崎修司, 田北智裕, 橋本洋一郎
    • Organizer
      第37回日本脳卒中学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Current clinical manifestations of CADASIL patients reported from Japan2012

    • Author(s)
      Hirano T
    • Organizer
      8thWorld Stroke Congress
    • Place of Presentation
      Brasilia
    • Related Report
      2012 Final Research Report
  • [Presentation] Hereditary small vessel disease in Japan2012

    • Author(s)
      Hirano T
    • Organizer
      Asian Pacific Stroke Conference 2012
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Final Research Report
  • [Presentation] Hereditary small vessel disease in Japan.2012

    • Author(s)
      Hirano T
    • Organizer
      Asian Pacific Stroke Conference 2012
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Current clinical manifestations of CADASIL patients reported from Japan.2012

    • Author(s)
      Hirano T
    • Organizer
      8th World Stroke Congress
    • Place of Presentation
      Brasilia
    • Related Report
      2012 Annual Research Report
  • [Presentation] 緊急脳血管内血行再建術の病巣縮小効果:脳血流SPECTによる検討2011

    • Author(s)
      平野照之
    • Organizer
      第16回脳SPECT・PETカンファレンス
    • Place of Presentation
      中小企業振興センター(福岡)
    • Year and Date
      2011-05-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 急性期血行再建の最新動向2011

    • Author(s)
      平野照之
    • Organizer
      第48回日本リハビリテーション医学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] CADASIL and CARASIL in Japan2011

    • Author(s)
      Hirano T
    • Organizer
      5thJapanese-Korean Joint Stroke Conference
    • Place of Presentation
      Gyeongju, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] t-PA 治療に関する医療機関の意識調査: 地域格差の解消に向けて2011

    • Author(s)
      平野照之
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] Prospective multicenter study on prevention using cilostazol from acute stroke progression. Study design and 1st preliminary report2010

    • Author(s)
      Hirano T, Terasaki T, Yonehara T, Takita T, Hashimoto Y, Uchino M
    • Organizer
      7th World Stroke Congress
    • Place of Presentation
      Seoul
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of emergent neuro-endovascular revascularization on infarct size reduction: Evaluation using sub-6 hour 99mTc-HMPAO SPECT based system2010

    • Author(s)
      Hirano T, Watanabe M, Kai Y, Shiraishi S, Kawano H, Uchino M
    • Organizer
      19thEuropean Stroke Conference
    • Place of Presentation
      Barcelona
    • Related Report
      2012 Final Research Report
  • [Presentation] 緊急脳血管内血行再建術の病巣縮小効果: 脳血流 SPECT による検討2010

    • Author(s)
      平野照之, 渡邉聖樹, 甲斐豊, 白石慎哉, 河野浩之, 内野誠
    • Organizer
      第51回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] for the Kumamoto-PENTAGON study group: シロスタゾールとアスピリンの進行型脳梗塞に関する前向き共同臨床比較試験(第1報)2010

    • Author(s)
      平野照之, 米原敏郎, 寺崎修司, 田北智裕 , 橋本洋一郎 , 内 野 誠
    • Organizer
      第35回日本脳卒中学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 緊急脳血管内血行再建術の病巣縮小効果:脳血流SPECTによる検討2010

    • Author(s)
      平野照之
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of emergent neuro-endovascular revascularization on infarct size reduction : Evaluation using sub-6h SPECT based system2010

    • Author(s)
      平野照之
    • Organizer
      2010欧州脳卒中会議
    • Place of Presentation
      カタルーニャ国際会議場バルセロナ(スペイン)
    • Related Report
      2010 Annual Research Report
  • [Book] 慢性期の再発予防にどのように用いるか. 心原性脳塞栓症と抗凝固療法2013

    • Author(s)
      豊田一則編
    • Publisher
      フジメディカル出版
    • Related Report
      2012 Final Research Report
  • [Book] CT angiography (CTA). 脳卒中レジデントマニュアル第2 版2013

    • Author(s)
      峰松一夫監修, 横田千晶編
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] MRI, MRA. 脳卒中レジデントマニュアル第2版2013

    • Author(s)
      峰松一夫監修, 横田千晶編
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] CT. 脳卒中レジデントマニュアル第2版2013

    • Author(s)
      峰松一夫監修, 横田千晶編
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] stroke care unit と stroke unit. 必携脳卒中ハンドブック改訂第2 版2011

    • Author(s)
      田中耕太郎, 高嶋修太郎編
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 排尿障害. ナースのための脳神経外科改訂第3版2010

    • Author(s)
      平野照之
    • Publisher
      メディカ出版
    • Related Report
      2012 Final Research Report
  • [Book] 脳神経疾患の画像の見かた2010

    • Author(s)
      平野照之監修
    • Publisher
      メディカ出版
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.oita-u.ac.jp/naika3/shinkei.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi