| Project/Area Number |
22590960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
IMAI Tomihiro 札幌医科大学, 医学部, 講師 (40231162)
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| Co-Investigator(Kenkyū-buntansha) |
HOZUKI Takayoshi 札幌医科大学, 医学部, 研究員 (80464501)
TSUDA Emiko 札幌医科大学, 医学部, 研究員 (90464495)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 臨床神経生理学 / 重症筋無力症 / プレドニゾロン / 興奮収縮連関 / 咬筋 / 短母指外転筋 / 単線維筋電図 / safety factor / staircase現象 / 抗リアノジン受容体抗体 / タクロリムス |
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| Research Abstract |
The results of this study were:
The results of this study were: 1) to develop measurement of excitation-contraction coupling time (ECCT) of masseter using an accelerometer;
2) to elucidate the relationship between the impairment of E-C coupling of masseter and the bite force in patients with myasthenia gravis (MG).
Masseteric E-C coupling is impaired in some MG patients, and functional recovery of E-C coupling contributes to the increase in biteforce at least in part after treatment.
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