| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
KATP channel is suggested to regulate cellular excitability of various cell types by acting as a metabolic sensor. Especially, the channel in the hypothalamus, the metabolic center in the body, plays an important role in metabolic regulation of insulin targeted tissues. In the present study, we found that insulin signaling in the adipose tissues is modulated exogenously by the brain KATP channel and that KATP channel is involved in the glucose sensing in several nuclei in the brain stem as well as the hypothalamus.
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