| Project/Area Number |
22590972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Fukui |
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Principal Investigator |
SUZUKI Jinya 福井大学, 医学部, 助教 (20293417)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Sadao 福井大学, 医学部附属病院, 講師 (50303376)
KOIZUMI Tsutomu 福井大学, ライフサイエンス支援センター, 准教授 (40126579)
HIROSE Masamichi 岩手医科大学, 薬学部, 教授 (40273081)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病性心筋症 / 脂肪毒性 / 脂肪滴 / エネルギー代謝 / 心筋症 / 線維化 |
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| Research Abstract |
Function of cardiac ADRP, a lipid-droplet associated protein, was analyzed in a diabetic mouse model. Cardiac-specific ARRP-overexpressing (Tg) mice, global ADRP-KO mice (KO) and wildtype (Wt) littermates were treated with streptozotocin to induce diabetes. Despite massive lipid accumulation, systolic function was maintained in diabetic Tg mice with ameliorated diabetic gene expression profile.Packaging excess fatty acids into lipid droplets, cardiac ADRP might play a role in protecting cardiomyocytes against lipotoxicity in diabetes.
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