Function of ADRP in the pathogenesis of diabetic cardiomyopathy
Project/Area Number |
22590972
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | University of Fukui |
Principal Investigator |
SUZUKI Jinya 福井大学, 医学部, 助教 (20293417)
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Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Sadao 福井大学, 医学部附属病院, 講師 (50303376)
KOIZUMI Tsutomu 福井大学, ライフサイエンス支援センター, 准教授 (40126579)
HIROSE Masamichi 岩手医科大学, 薬学部, 教授 (40273081)
|
Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 糖尿病性心筋症 / 脂肪毒性 / 脂肪滴 / エネルギー代謝 / 心筋症 / 線維化 |
Research Abstract |
Function of cardiac ADRP, a lipid-droplet associated protein, was analyzed in a diabetic mouse model. Cardiac-specific ARRP-overexpressing (Tg) mice, global ADRP-KO mice (KO) and wildtype (Wt) littermates were treated with streptozotocin to induce diabetes. Despite massive lipid accumulation, systolic function was maintained in diabetic Tg mice with ameliorated diabetic gene expression profile.Packaging excess fatty acids into lipid droplets, cardiac ADRP might play a role in protecting cardiomyocytes against lipotoxicity in diabetes.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/502012
Author(s)
T. Kimura, J. Suzuki, M. Ichikawa, M. Imagawa, S. Sato, M. Fujii, Y. Zenimaru, S. Inaba, S. Takahashi, T. Konoshita, I. Miyamori
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Journal Title
Diabetes Technol Ther
Volume: 14
Pages: 545-551
Related Report
Peer Reviewed
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[Journal Article] Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: effect of a high-dose statin on VLDL receptor expression2011
Author(s)
M. Imagawa, S. Takahashi, Y. Zenimaru, T. Kimura, J. Suzuki, I. Miyamori, T. Iwasaki, H. Hattori, T.T. Yamamoto, T. Nakano, K. Nakajima
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Journal Title
Clin Chim Acta
Volume: 431
Pages: 441-447
Related Report
Peer Reviewed
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[Journal Article] Species differences of macrophage very low-densitylipoprotein (VLDL) receptor protein expression2011
Author(s)
S. Takahashi, T. Ito, Y. Zenimaru, J. Suzuki, I. Miyamori, M. Takahashi, M. Takahashi, T. Ishida, T. Ishida, K. Hirata, T.T. Yamamoto, T. Iwasaki, H. Hattori, M. Shiomi
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Journal Title
Biochem Biophys Res Commun
Volume: 407
Pages: 656-662
Related Report
Peer Reviewed
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[Presentation] Function of cardiac adipose differentiation-related protein (ADRP) in the pathogenesis of diabetic cardiomyopathy.2011
Author(s)
J. Suzuki, T. Kimura, M. Ichikawa, M. Imagawa, S. Takahashi, S. Ikuyama, T. Koizumi, M. Ueno, F.B. Kraemer, I. Miyamori
Organizer
47th EASD Annual Meeting
Place of Presentation
Lisbon, Portugal
Year and Date
2011-09-15
Related Report
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