| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In this study, we clarified the effect of GIP on adipose tissue in vivo using adipose tissue specific GIP receptor-deficient mice (GIPR^<adipo-/->). We fed high-hat diet (HFD) to aP2-Cre transgenic mice (aP2-Cre), floxed GIP receptor (lox-GIPR), and GIPR^<adipo-/->for 8 weeks. Body weight changes were significantly lower in GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR. Oral glucose tolerance test showed that insulin levels were significantly lower in GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR, although blood glucose levels did not differ among three types of mice. Insulin tolerance test showed that insulin resistance was improved in GIPR^<adipo-/->. Liver mass and fat content in liver were decreasedin GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR. These results suggested that inhibition of GIP receptor signal in adipose tissue might decrease fat content in liver and improve insulin resistance under HFD-fed condition.
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