Role of GIP receptor signal in adipose tissue

• Project/Area Number: 22590975
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kyoto University
• Principal Investigator: HARADA Norio 京都大学, 大学院・医学研究科 糖尿病・栄養内科学, 助教 (50530169)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: GIP / インクレチン / 肥満

Research Abstract

In this study, we clarified the effect of GIP on adipose tissue in vivo using adipose tissue specific GIP receptor-deficient mice (GIPR^<adipo-/->). We fed high-hat diet (HFD) to aP2-Cre transgenic mice (aP2-Cre), floxed GIP receptor (lox-GIPR), and GIPR^<adipo-/->for 8 weeks. Body weight changes were significantly lower in GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR. Oral glucose tolerance test showed that insulin levels were significantly lower in GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR, although blood glucose levels did not differ among three types of mice. Insulin tolerance test showed that insulin resistance was improved in GIPR^<adipo-/->. Liver mass and fat content in liver were decreasedin GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR. These results suggested that inhibition of GIP receptor signal in adipose tissue might decrease fat content in liver and improve insulin resistance under HFD-fed condition.

Research Products

• [Journal Article] Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice (2013)
  • Author(s): Joo E, Yamane S, Hamasaki A, Harada N, Matsunaga T, Muraoka A, Suzuki K, Nasteska D, Fukushima T, Hayashi T, Tsuji H, Shide K, Tsuda K, Inagaki N
  • Journal Title: Nutrition Volume: 29(3):549-55 Issue: 3 Pages: 549-555
  • DOI: 10.1016/j.nut.2012.09.007
  • NAID: 120005242568
  • Peer Reviewed
• [Journal Article] Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity. (2013)
  • Author(s): Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N.
  • Journal Title: J Biol Chem. Volume: 288 Issue: 3 Pages: 1929-1938
  • DOI: 10.1074/jbc.m112.423137
  • NAID: 120005373090
  • Peer Reviewed
• [Journal Article] Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study) (2013)
  • Author(s): Harashima S, Fukushima T, Sasaki M, Nishi Y, Fujimoto S, Ogura M, Yamane S, Tanaka D, Harada N, Hamasaki A, Nagashima K, Nakahigashi Y, Seino Y, Inagaki N
  • Journal Title: Diabetes Metab Res Rev Volume: 29(1):77-84 Issue: 1 Pages: 77-84
  • DOI: 10.1002/dmrr.2363
  • Peer Reviewed
• [Journal Article] The effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance (2012)
  • Author(s): Yamane S, Harada N, Hamasaki A, Muraoka A, Joo E, Suzuki K, Tanaka D, Ogura M, Harashima S, Inagaki N
  • Journal Title: J Diabetes Invest Volume: 3(1): 80-85 Issue: 1 Pages: 80-85
  • DOI: 10.1111/j.2040-1124.2011.00143.x
  • Peer Reviewed
• [Journal Article] Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion (2012)
  • Author(s): Sakamoto E, Seino Y, Fukami N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N
  • Journal Title: J Diabetes Invest Volume: 3(5):432-440 Issue: 5 Pages: 432-440
  • DOI: 10.1111/j.2040-1124.2012.00208.x
  • Peer Reviewed
• [Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice (2012)
  • Author(s): Ogawa E, Hosokawa M, Harada N, Yamane S, Hamasaki A, Toyoda K, Fujimoto S, Fujita Y, Fukuda K, Tsukiyama K, Yamada Y, Seino Y, Inagaki N
  • Journal Title: Biochem Biophys Res Commun Volume: 404(1):115-20
  • NAID: 120002737766
  • Peer Reviewed
• [Journal Article] Role of sodium-glucose transporters in glucose uptake of the intestine and kidney (2012)
  • Author(s): Harada N and Inagaki N
  • Journal Title: J Diabetes Invest Volume: 3(4):352-353 Issue: 4 Pages: 352-353
  • DOI: 10.1111/j.2040-1124.2012.00227.x
  • Peer Reviewed
• [Journal Article] 治療経過中に生じた血糖値不安定に対して CGM が有用であったインスリン抗体陽性糖尿病の 1 例 (2012)
  • Author(s): 福島 徹, 原田 範雄, 佐々木 真弓, 田中 大祐, 濱崎 暁洋, 長嶋 一昭, 八幡 三喜男, 稲垣 暢也
  • Journal Title: 糖尿病 Volume: 55巻12号 Pages: 966-972
  • NAID: 10031170439
  • Peer Reviewed
• [Journal Article] 全身性強皮症に合併したGAD 抗体および IA-2 抗体陽性劇症 1 型糖尿病の 1 例 (2012)
  • Author(s): 佐々木 真弓, 原田 範雄, 佐藤 広規, 豊田 健太郎, 濱崎 暁洋, 長嶋 一昭, 藤本新平, 稲垣 暢也
  • Journal Title: 糖尿病 Volume: 55巻 10号 Pages: 781-785
  • NAID: 10031136858
  • Peer Reviewed
• [Journal Article] Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice (2011)
  • Author(s): Himeno T, Seino Y, et al.
  • Journal Title: Diabetes Volume: 60 Issue: 9 Pages: 2397-2406
  • DOI: 10.2337/db10-1462
  • Peer Reviewed
• [Journal Article] Plasma GIP and GLP-1 levels after glucose loading are associated with different factors in Japanese subjects (2011)
  • Author(s): Harada N, Hamasaki A, Muraoka A, Yamane S, Joo E, Fujita K, Inagaki N
  • Journal Title: J Diabetes Invest Volume: 2(3):193-199 Issue: 3 Pages: 186-192
  • DOI: 10.1111/j.2040-1124.2010.00078.x
  • Peer Reviewed
• [Journal Article] GLP-1 receptor agonist attenuates ER stress-mediatedβ-cell damage in Akita mice (2011)
  • Author(s): Yamane S, Hamamoto Y, Toyoda K, Seino Y Inagaki N, et al.
  • Journal Title: Journal of Diabetes Investigation Volume: 2 Issue: 2 Pages: 79-154
  • DOI: 10.1111/j.2040-1124.2010.00075.x
  • Peer Reviewed
• [Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice (2011)
  • Author(s): Ogawa E, Hosokawa M, Harada N, Yamane S, Hamasaki A, Toyoda K, Fujimoto S, Fujita Y, Fukuda K, Tsukiyama K, Yamada Y, Seino Y, Inagaki N
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 404 Pages: 115-120
  • NAID: 120002737766
  • Peer Reviewed
• [Journal Article] 【インクレチン研究と創薬への展開】GIPとGLP-1の膵島への作用 (2011)
  • Author(s): 原田範雄, 稲垣暢也
  • Journal Title: 最新医学 Volume: 66 Pages: 21-27
• [Journal Article] Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation (2010)
  • Author(s): Kawasaki Y, Toyoda K, Yamane S, Seino Y, N. Inagaki et al.
  • Journal Title: Hormone and Metabolic Research Volume: 42 Issue: 05 Pages: 311-317
  • DOI: 10.1055/s-0030-1249035
  • Peer Reviewed
• [Journal Article] GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated b-cell damage in Akita mice (2010)
  • Author(s): Yamane S, Hamamoto Y, Harashima S, Harada N, Hamasaki A, Toyoda K, Fujita K, Joo E, Seino Y, Inagaki N
  • Journal Title: Journal of Diabetes Investigation Volume: (in press)
  • Peer Reviewed
• [Journal Article] Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation. (2010)
  • Author(s): Kawasaki Y, Harashima S, Sasaki M, Mukai E, Nakamura Y, Harada N, Toyoda K, Hamasaki A, Yamane S, Yamada C, Yamada Y, Seino Y, Inagaki N.
  • Journal Title: Horm Metab Res. Volume: 42 Pages: 311-317
  • Peer Reviewed
• [Journal Article] Plasma GIP and GLP-1 levels after glucose loading are associated with different factors in Japanese subjects (2010)
  • Author(s): Harada N, Hamasaki A, Muraoka A, Yamane S, Joo E, Fujita K, Inagaki N
  • Journal Title: Journal of Diabetes Investigation Volume: 2 Pages: 104-110
  • Peer Reviewed
• [Journal Article] 【糖尿病診療2010】糖尿病の早期治療 薬物療法 インクレチン関連薬DPP-4阻害薬の特徴と適応 (2010)
  • Author(s): 原田範雄, 稲垣暢也
  • Journal Title: 日本医師会雑誌 Volume: 139
• [Journal Article] 【糖尿病大血管症 エビデンスに基づく発症・進展制御】インクレチンとインクレチン関連薬 (2010)
  • Author(s): 原田範雄, 稲垣暢也
  • Journal Title: 日本臨床 Volume: 68 Pages: 931-942
• [Journal Article] 【糖尿病大血管症 エビデンスに基づく発症・進展制御】インクレチンとインクレチン関連薬 (2010)
  • Author(s): 原田範雄, 稲垣暢也
  • Journal Title: 糖尿病レクチャー Volume: 1 Pages: 31-37
• [Presentation] The effect of GIP on high-fat induce obesity (2013)
  • Author(s): Harada N, Yamane S, Hamasaki A, Inagaki N
  • Organizer: 26th Spring Congress of Korean Diabetes Association/1st Korea-Japan Diabetes Forum
  • Place of Presentation: Jeju, Korea
• [Presentation] 高脂肪食負荷状態におけるGIP分泌の検討 (2012)
  • Author(s): 原田範雄, 鈴木和代, 濱崎暁洋, 山根俊介, Danila Nasteska, 佐々木香月, 中村康彦, 稲垣暢也
  • Organizer: 第26回日本糖尿病・肥満動物学会学術集会
  • Place of Presentation: 愛知県産業労働センター
  • Year and Date: 2012-02-17
• [Presentation] Effect of insufficient GIP secretion on high-fat diet induced obesity (2012)
  • Author(s): Harada N, Yamane S, Hamasaki A, InagakiN
  • Organizer: 9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Kyoto, Japan
• [Presentation] 高脂肪食負荷状態における GIP 分泌の検討 (2012)
  • Author(s): 原田 範雄, 藤田 和代,浜崎 暁洋,山根 俊介,Dainela Nasteska,佐々木 香月,中村 靖彦,稲垣 暢也
  • Organizer: 第23回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 名古屋
• [Presentation] 高脂肪食負荷状態における GIP 分泌及び作用の検討 (2012)
  • Author(s): 原田 範雄, 山根 俊介, 浜崎 暁洋, 稲垣
  • Organizer: 第55回 日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
• [Presentation] Lowering G1P secretion has beneficial role in reducing obesity and insulin resistance without impairing glucose tolerance and osteogensis (2012)
  • Author(s): Nasteska, D., Harada, N, Yamane, S., Suzuki, K., Hamasaki, A., Joo, E., Sasaki, K., Shibue, K., Harada, T., Nakamura, Y., Inagaki, N
  • Organizer: 47th EASD (European Association for the Study of Diabetes) Annual Meeting
  • Place of Presentation: Berlin, Germany
• [Presentation] A cross-sectional study for assessment and validation of the estimated formula of 2-hour post-challenge glucose level composing fasting glucose level and HbA1c. (2012)
  • Author(s): Kondo,Y., Harada, N., Hamasaki, A., Nasteska, D., Yamane, S., Muraoka, A., Sozu, T., Inagaki, N
  • Organizer: 47th EASD (European Association for the Study of Diabetes) Annual Meeting
  • Place of Presentation: Berlin, Germany
• [Presentation] Effect of insufficient GIP secretion on high-fat diet induced obesity. (2012)
  • Author(s): Harada, N., Yamane, S., Hamasaki, A., Inagaki, N
  • Organizer: 9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Kyoto, Japan
  • Invited
• [Presentation] The effect of high-fat diet induced obesity on GIP secretion from K-cells. (2012)
  • Author(s): Suzuki, K., Harada, N., Yamane, S., Hamasaki, A., Nasteska, D., Sasaki, K., Joo, E., Shibue, K., Harada, T., Muraoka, A., Kondo, Y., Nakamura, Y., Inagaki, N.
  • Organizer: 9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Kyoto, Japan
• [Presentation] Assessment of gene expression in enteroendocrine K-cells. (2012)
  • Author(s): Sasaki, K., Harada, N., Yamane, S., Hamasaki, A., Suzuki, K., Nasteska, D., Muraoka, A., Joo, E., Kondo, Y., Shibue, K., Harada, T., Inagaki, N.
  • Organizer: 9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Kyoto, Japan
• [Presentation] Incretin effect in Japanese subjects with normal glucose tolerance and type 2 diabetes. (2012)
  • Author(s): Hamasaki, A., Harada, N., Yamane, S., Inagaki, N.
  • Organizer: 9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Kyoto, Japan
• [Presentation] The Effect of High-fat Diet-induced Obesity on Secretion of Gastric Inhibitory Polypeptide from K-cells (2011)
  • Author(s): Norio Harada, Suzuki Kazuyo, Daniela Nasteska, Akihiro Hamasaki, Shunsuke Yamane, Nobuya Inagaki
  • Organizer: 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2011-10-21
• [Presentation] 高スクロース食負荷マウスにおける耐糖能障害発症機序の検討 (2011)
  • Author(s): 坂本英里子, 尾崎信暁, 清野祐介, 深見亜也子, 佐藤寛之, 原田範雄, 水谷直広, 豊田行康, 三輪一智, 稲垣暢也, 大磯ユタカ
  • Organizer: 第14回日本病態栄養学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-01-15
• [Presentation] The effect of high-fat diet induced obesity on secretion of gastric inhibitory polypeptide from K-cells (2011)
  • Author(s): Harada N, Suzuki K, Nasteska D, YamaneS, Hamasaki A. Inagaki N
  • Organizer: 16th Japan-Korea Symposium on Diabetes Mellitus
  • Place of Presentation: Tokyo, Japan
• [Presentation] GIP分泌抑制のインスリン分泌と高脂肪食肥満に及ぼす影響 (2011)
  • Author(s): 藤田和代, 原田範雄, 浜崎暁洋, Daniela Nasteska, 山根俊介, 城尾恵里奈, 村岡敦, 菱澤方洋, 近藤八重子, 劉喜宝, 稲垣暢也
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌プリンスホテル
• [Presentation] 日本人健常者のインクレチン分泌とインクレチン作用 (2010)
  • Author(s): 原田 範雄, 山根 俊介, 浜崎 暁洋, 稲垣 暢也
  • Organizer: 第47回日本糖尿病学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-13
• [Presentation] Incretin secretion and incretin effect in Japanese (2010)
  • Author(s): Norio Harada, Akihiro Hamasaki, Atsushi Muraoka, Shunsuke Yamane, Erina Joo, Kazuyo Fujita, Tomoko Takano, Nobuya Inagaki
  • Organizer: Asia Ilet Biology & Incretin Symposium(AIBIS)
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2010-07-31
• [Presentation] The effects of glucose and meal ingestion on incretin secretion in Japanese subjects (2010)
  • Author(s): Kazuyo Fujita, Norio Harada, Akihiro Hamasaki, Shunsuke Yamane, Atsushi Muraoka, Erina Joo, Nobuya Inagaki
  • Organizer: Asia Ilet Biology & Incretin Symposium(AIBIS)
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2010-07-31
• [Presentation] Plasma GIP and GLP-1 levels are associated with distinct factors after glucose loading in Japanese subjects (2010)
  • Author(s): Norio Harada, Akihiro Hamasaki, Atsushi Muraoka, Shunsuke Yamane, Erina Joo, Kazuyo Fujita, Tomoko Takano, Nobuya Inagaki
  • Organizer: ADA 70th Scientific Sessions
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2010-06-25
• [Presentation] Plasma GIP and GLP-1 levels are associated with distinct factors after glucose loading in Japanese subjects (2010)
  • Author(s): Norio Harada, Akihiro Hamasaki, Atsushi Muraoka, Shunsuke Yamane, Erina Joo, Kazuyo Fujita, Tomoko Takano, Nobuya Inagaki
  • Organizer: AASD 2th 70th Scientific Meeting
  • Place of Presentation: Okayama Japan
  • Year and Date: 2010-05-29
• [Presentation] Incretin effect of Japanese subjects (2010)
  • Author(s): Akihiro Hamasaki, Norio Harada, Atsushi Muraoka, Shunsuke Yamane, Erina Joo, Kazuyo Fujita, Tomoko Takano, Nobuya Inagaki
  • Organizer: AASD 2th 70th Scientific Meeting
  • Place of Presentation: Okayama Japan
  • Year and Date: 2010-05-29
• [Presentation] 日本人におけるインクレチン効果の検討 (2010)
  • Author(s): 浜崎暁洋, 村岡敦, 原田範雄, 山根俊介, 豊田健太郎, 藤田和代, 城尾恵理奈, 稲垣暢也
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] 日本人健常者における糖負荷後インクレチン分泌と関連因子についての検討 (2010)
  • Author(s): 山根俊介, 原田範雄, 濱崎暁洋, 村岡敦, 藤田和代, 城尾恵里奈, 劉喜宝, 稲垣暢也
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] 2型糖尿病患者における脂質管理目標未達成者の未達成理由の医師へのアンケート調査 (2010)
  • Author(s): 細川雅也, 濱崎暁洋, 藤田義人, 藤本新平, 長嶋一昭, 豊田健太郎, 原島伸一, 山田千積, 原田範雄, 佐々木真弓, 稲垣暢也
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] 減量による肥満の改善に伴うインクレチン分泌と効果の経過を評価しえた1例 (2010)
  • Author(s): 村岡敦, 浜崎暁洋, 原田範雄, 山根俊介, 藤田和代, 城尾恵里奈, 稲垣暢也
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] GIP-GFP knock-inマウスを用いた高脂肪食肥満におけるGIP分泌の検討 (2010)
  • Author(s): 藤田和代, 濱崎暁洋, 原田範雄, 山根俊介, 村岡敦, 城尾恵里奈, 稲垣暢也
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-28
• [Presentation] Plasma GIP and GLP-1 levels are associated with distinct factors after glucose loading in Japanese subjects (2010)
  • Author(s): Harada N, Hamasaki A, Muraoka A, YamaneS, Joo E, Fujita K, Takano T, Inagaki N
  • Organizer: American Diabetes Association 70th Scientific Sessions
  • Place of Presentation: Orland, FL
• [Book] 薬局【インクレチン関連薬】 徹底比較!DPP-4 阻害薬 vs GLP-1 受容体作動薬体重減少作用 (2012)
  • Author(s): 原田 範雄
  • Publisher: 南山堂
• [Book] 【糖尿病診療における検査:最新トピックス】 インクレチン測定 (2012)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 医学出版
• [Book] 【インクレチン関連薬の現状と課題】 インクレチン関連薬の新しい知見と話題 肥満とインクレチン (2012)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: ライフ・サイエンス社
• [Book] 【糖尿病の薬物療法 - 最新の治療と将来展望】 治療薬解説DPP-4 阻害薬と GLP-1 受容体作動薬 (2012)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: ライフメディコム, カレントテラピー
• [Book] 【糖尿病治療薬2012 皆が知りたい新しい治療 A to Z】 変化する抗糖尿病薬内服治療 DPP-4 阻害薬が蘇らせる GIP (2012)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 医学書院
• [Book] 【変貌する糖尿病治療】 糖尿病治療薬 DPP-4 阻害薬. 臨牀と研究 (2012)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 大道學館出版部
• [Book] 薬局, 63巻13号 (2012)
  • Author(s): 原田 範雄
  • Publisher: 南山堂
• [Book] 月刊糖尿病4巻13号 (2012)
  • Author(s): 原田範雄 稲垣暢也
  • Publisher: 医学出版
• [Book] Progress in Medicine (2012)
  • Author(s): 原田範雄 稲垣暢也
  • Publisher: ライフサイエンス社
• [Book] カレントテラピー30巻7号 (2012)
  • Author(s): 原田範雄 稲垣暢也
  • Publisher: ライフメディコム
• [Book] Medicine 49巻5号 (2012)
  • Author(s): 原田範雄 稲垣暢也
  • Publisher: 医学書院
• [Book] 臨牀と研究89巻1号 (2012)
  • Author(s): 原田範雄 稲垣暢也
  • Publisher: 大道學館出版部
• [Book] 【インクレチン療法-インクレチン治療で何が変わったか-】インクレチンの基礎と臨床 GIP の肥満への影響 (2011)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 医学出版
• [Book] 【内分泌器官としての消化管とその疾病～消化管ペプチドの意義と応用～】 GLP-1 と関連疾患 (2011)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 医薬ジャーナル社
• [Book] 消化管とエネルギー代謝】インクレチン GIP と GLP-1 (2011)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: ニュー・サイエンス社
• [Book] 【インクレチン関連薬 糖尿病治療のパラダイムシフト】 インクレチンの基礎・臨床研究の進歩 インクレチン受容体の構造と機能 G タンパク共役型受容体としての特性 (2011)
  • Author(s): 原田 範雄
  • Publisher: 日本臨床社
• [Book] 【糖尿病診断基準 2010 臨床での応用と実際】その他の血糖管理指標の測定法とその基準値に関する項目 インクレチン濃度とその評価の意義 (2011)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 総合医学社
• [Book] 【代謝・内分泌ネットワークと医薬応用 摂食・エネルギー調節に関わる生理活性ペプチドの機能と糖尿病やメタボリックシンドロームを標的とした創薬展開】 生理活性ペプチドと疾患・臨床応用 生理活性ペプチドの臨床応用 インクレチンとインクレチンを応用した治療の可能性 (2011)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 羊土社
• [Book] 【インクレチン研究と創薬への展開】 GIP と GLP-1 の膵島への作用 (2011)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 最新医学社
• [Book] 【インクレチン療法 実践ブラッシュアップ】体重におよぼすインクレチンの作用 (2011)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 診断と治療社
• [Book] 【糖尿病診療2010】 糖尿病の早期治療 薬物療法 インクレチン関連薬 DPP-4 阻害薬の特徴と適応 (2010)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 日本医師会
• [Book] 【新しい経口糖尿病薬療法 インクレチン薬をめぐって】 インクレチンの膵作用と膵外作用とは(Q&A/特集) (2010)
  • Author(s): 藤田 和代, 原田 範雄, 稲垣 暢也
  • Publisher: 総合医学社
• [Book] 【糖尿病大血管症 エビデンスに基づく発症・進展制御】 インクレチンとインクレチン関連薬 (2010)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 日本臨床社
• [Book] 【インクレチン】 インクレチンの基礎 Dipeptidyl peptidase-4(DPP-4) (2010)
  • Author(s): 原田 範雄
  • Publisher: 医学出版
• [Book] 新しい糖尿病薬(インクレチン関連薬)の使い方 (2010)
  • Author(s): 藤田 義人, 原田 範雄, 稲垣 暢也
  • Publisher: 羊土社
• [Book] 【レジデント必携 糖尿病診療の ABC (岡本元純編)II.】 レクチャー インクレチンとインクレチン関連薬 (2010)
  • Author(s): 原田 範雄
  • Publisher: 文光堂
• [Book] 【糖尿病研修ノート】DPP-4 阻害薬 (2010)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 診断と治療社
• [Book] 【糖尿病診断基準 2010 -臨床での応用と実際-】インクレチン濃度とその評価の意義 (2010)
  • Author(s): 原田 範雄, 稲垣 暢也
  • Publisher: 総合医学社