Analysis about the factors that affect the postnatal formationand function of pancreatic β-cell in connection with the intrauterine undernutrition.
Project/Area Number |
22590976
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Kyoto University |
Principal Investigator |
TOYODA Kentaro 京都大学, 医学(系)研究科, 講師 (00447971)
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Co-Investigator(Kenkyū-buntansha) |
HAMAZAKI Akihiro 京都大学, 医学(系)研究科, 助教 (40456900)
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | エネルギー / 糖質代謝異常 / イメージング / 糖尿病 / 糖代謝異常 / 膵島 |
Research Abstract |
The aim of this study is to analyze the factors that affect the postnatal formation of pancreatic β-cell mass and function in connection with the intrauterine undernutrition. Although, pregnant mice were divided into two groups; calorie restriction group and control diet group, an individual difference of the daily intake volume severely large unexpectedly. Therefore, in the period of this project, we could not compare with both groups. For detail observation of the change in pancreatic β-cell mass during embryonic and postnatal period, we analyzed the pregnant mice and fetal mice whose pancreatic β-cell express luciferase by using IVIS system and optical projection tomography (OPT). Luciferine injection enabled us to observe the mass of fetal islets in the pregnant mice by IVIS and the number and volume of fetal islet were quantified by OPT analysis.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.2013
Author(s)
Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N.
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Journal Title
J Biol Chem.
Volume: 288
Issue: 3
Pages: 1929-1938
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice2011
Author(s)
Ogawa E, Hosokawa M, Harada N, Yamane S, Hamasaki A, Toyoda K, Fujimoto S, Fujita Y, Fukuda K, Tsukiyama K, Yamada Y, Seino Y, Inagaki N.
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Journal Title
Biochem.Biophys.Res.Commun.
Volume: 404
Pages: 115-120
NAID
Related Report
Peer Reviewed
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[Journal Article] Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phophorylation.2010
Author(s)
Kawasaki Y, Harashima S, Sasaki M, Mukai E, Nakamura Y, Harada N, Toyoda K, Hamasaki A, Yamane S, Yamada C, Yamada Y, Seino Y, Inagaki N
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Journal Title
Hormone and Metabolic Research
Volume: 42
Pages: 311-317
Related Report
Peer Reviewed
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[Presentation] Development of Non-Invasive PET Probe for Quantifying Pancreatic B-Cell Mass Using Fluorine-18-Labeled Exendin-42012
Author(s)
Fujimoto, H., Toyoda, K., Kimura, H., Saji, H., Inagaki, N (他 8 人)
Organizer
9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
Kyoto, Japan
Year and Date
2012-11-27
Related Report
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[Presentation] 膵β細胞GLP-1受容体を標的とするSPECT用イメージングプローブExendin(9-39)誘導体の開発2011
Author(s)
小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
Organizer
第51回日本核医学会学術総会
Place of Presentation
筑波(茨城)
Year and Date
2011-10-28
Related Report
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[Presentation] Non-Invasive SPECT Imaging of Pancreatic Islets Targeting Glueagon-Like Peptide-1 Receptors2011
Author(s)
Fujimoto H, Toyoda K, Kimura H, Ogawa Y, Mukai E, Xiaotong Z, Kawashima H, Ueda M, Matsuda H, Hirao K, Saji H, Inagaki N
Organizer
American Diabetes Association 71th Scientific Sessions
Place of Presentation
サン・ディエゴ(米国)
Year and Date
2011-06-30
Related Report
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[Presentation] Development of Non-Invasive PET Probe for Quantifying Pancreatic β-cell mass using Fluorine-18-Labeled Exendin-42011
Author(s)
Toyoda K, Kimura H, Fujimoto H, Xiaotong Z, Mukai E, Ogawa Y, Hirao K, Matsuda H, Kawashima H, Ueda M, Temma T, Saji H, Inagaki
Organizer
American Diabetes Association 71th Scientific Sessions
Place of Presentation
サン・ディエゴ(米国)
Year and Date
2011-06-29
Related Report
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[Presentation] GLP-1受容体を標的とするSPECT用膵島イメージングプローブの開発2011
Author(s)
藤本裕之, 豊田健太郎, 木村寛之, 小川祐, 向英里, 庄暁桐, 上田真史, 天満敬, 河嶋秀和, 平尾佳, 松尾洋和, 永川健司, 佐治英郎, 稲垣暢也
Organizer
第54回日本糖尿病学会年次学術集会
Place of Presentation
札幌(北海道)
Year and Date
2011-05-21
Related Report
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[Presentation] GLP-I受容体を標的とする非侵襲的膵島イメージンのためのPET用プローブの開発2011
Author(s)
豊田健太郎, 木村寛之, 藤本裕之, 小川祐, 向英里, 庄暁桐, 河嶋秀和, 平尾佳, 松尾洋和, 永川健司, 佐治英郎, 稲垣暢也
Organizer
第54回日本糖尿病学会年次学術集会
Place of Presentation
札幌(北海道)
Year and Date
2011-05-19
Related Report
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[Presentation] GLP-1受容体を標的とする放射性ヨウ素標識イメージングプローブの開発2010
Author(s)
小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
Organizer
第50回日本核医学会学術総会
Place of Presentation
埼玉
Year and Date
2010-11-11
Related Report
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[Presentation] Non-Invasive PET Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors.2010
Author(s)
Toyoda K, Kimura H, Mukai E, Fujimoto H, Ogawa Y, Kawashima H, Ueda M, Temma T, Hirao K, Nagakawa K, Seino Y, Saji H, Inagaki N.
Organizer
8th IDF WPR Congress.
Place of Presentation
Busan, Korea
Year and Date
2010-10-20
Related Report
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[Presentation] Non-Invasive PET Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors.2010
Author(s)
Toyoda K, Kimura H, Mukai E, Fujimoto H, Ogawa Y, Kawashima H, Ueda M, Temma T, Hirao K, Nagakawa K, Seino Y, Saji H, Inagaki N.
Organizer
American Diabetes Association 70th Scientific Sessions.
Place of Presentation
Orland, U.S.A.
Year and Date
2010-06-28
Related Report
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[Presentation] Synthesis and evaluation of radioiodinated exendin derivatives for the imaging of GLP-1 receptor expression in pancreatic islets.2010
Author(s)
Kimura H, Ogawa Y, Kawashima H, Mukai E, Toyoda K, Fujimoto H, Hirao K, Ono M, Inagaki N, Saji H.
Organizer
Society of Nuclear Medicine 57th Annual Meeting
Place of Presentation
Tronto, Canada
Year and Date
2010-06-06
Related Report
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[Presentation] Development of Non-Invasive PET Probe for Quantifying Pancreatic B-Cell Mass Using Fluorine- 18-Labeled Exendin-4.
Author(s)
Fujimoto H, Toyoda K, Kimura H, Ogawa Y, Mukai E, Zhuang X, Ueda M, Temma T, Hirai M, Matsuda H, Saji H, Inagaki N.
Organizer
9th International Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes.
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] Development of 123I-labeled exendin derivative binding to GLP-1 receptors for imaging insulinoma by SPECT.
Author(s)
Matsuda H, Kimura H, Ogawa Y, Takagi M, Kon A, Ono M, Toyoda K, Inagaki N, Saji
Organizer
Society of Nuclear Medicine 59th Annual Meeting,
Place of Presentation
Miami, U.S.A
Related Report
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