Mechanism of adiponectin binding proteinson vascularmetabolism.

• Project/Area Number: 22590978
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka University
• Principal Investigator: KIHARA Shinji 大阪大学, 大学院・医学系研究科, 教授 (20332736)
• Co-Investigator(Kenkyū-buntansha): FUNAHASHI Tohru 大阪大学, 大学院・医学系研究科, 寄附講座教授 (60243234) ; MAEDA Norikazu 大阪大学, 大学院・医学系研究科, 助教 (30506308)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内科 / 脂質 / 蛋白質 / 細胞・組織 / 生体分子

Research Abstract

Cystatin C was identified as an adiponectin binding protein. In macrophage, adiponectin regulated vascular endothelial growth factor-C. In vascular endothelial cell culture, cystatin C abrogated the anti-inflammatory effects of adiponectin. The clearance rate of adiponectin was decreased by cystatin C in mouse model. Although adiponectin has anti-atherogenic properties, hyper-adiponectinemia in renal failure is associated with increased risk of atherosclerosis. The present findings suggest that the high cystatin C level of renal failure impaired vascular metabolism through the direct binding with adiponectin.

Research Products

• [Journal Article] Adiponectin Regulates Vascular Endothelial Growth Factor-C Expression in Macrophages via Syk-ERK Pathway (2013)
  • Author(s): Hu D, Fukuhara A, Miyata Y, Yokoyama C, Otsuki M, Kihara S, Shimomura I
  • Journal Title: PLoS One Volume: 8 Issue: 2 Pages: e56071-e56071
  • DOI: 10.1371/journal.pone.0056071
  • Peer Reviewed
• [Journal Article] Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway. (2013)
  • Author(s): Hu D
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Dynamic changes of adiponectin and S100A8 levels by the selective peroxisome proliferator-activated receptor-gamma agonist rivoglitazone (2011)
  • Author(s): Hiuge-Shimizu A, Kihara S, et al
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Issue: 4 Pages: 792-799
  • DOI: 10.1161/atvbaha.110.221747
  • Peer Reviewed
• [Journal Article] Increment and impairment of adiponectin in renal failure (2010)
  • Author(s): Komura N, Kihara S, Sonoda M, Maeda N, Tochino Y, Funahashi T, Shimomura I.
  • Journal Title: Cardiovasc Res Volume: 83 Pages: 471-477
  • Peer Reviewed
• [Journal Article] Increment and Impairment of Adiponectin in Renal Failure (2010)
  • Author(s): Komura N, Kihara S, et al.
  • Journal Title: Cardiovasc Res. Volume: 86巻 Pages: 471-477
  • Peer Reviewed
• [Presentation] Molecular link between visceral fat and metabolic syndrome. (2012)
  • Author(s): Shinji Kihara
  • Organizer: International Symposium on Atherosclerosis
  • Place of Presentation: ロイヤルパークホテル(東京)
  • Year and Date: 2012-03-24
• [Presentation] Molecular link between visceral fiat and metabolic syndrome (2012)
  • Author(s): Shinji Kihara
  • Organizer: Satellite Symposia of International Symposium on Atherosclerosis
  • Place of Presentation: ロイヤルパークホテル(東京)(招待講演)
  • Year and Date: 2012-03-24
• [Presentation] Adiponectin in metabolic syndrome and related disorders. (2010)
  • Author(s): 木原進士
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(招待講演)
  • Year and Date: 2010-10-02
• [Presentation] Adiponectin in metabolic syndrome and related disorders. (2010)
  • Author(s): Shinji Kihara
  • Organizer: 第42回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 岐阜都ホテル(岐阜)
  • Year and Date: 2010-07-15