Analysis of tissue accumulation and regulation of adiponectin

• Project/Area Number: 22590979
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka University
• Principal Investigator: MAEDA Norikazu 大阪大学, 医学系研究科, 助教 (30506308)
• Co-Investigator(Kenkyū-buntansha): 船橋 徹 (舟橋 徹) 大阪大学, 医学(系)研究科(研究院), 教授 (60243234)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内科 / 糖尿病 / 蛋白質

Research Abstract

Adenovirus-mediated supplement of adiponectin to adiponectin-deficient mice demonstrated that adiponectin was accumulated in the heart tissue and exhibited cardio-protective role. S100A8 was identified as a novel adipocytokine from mice white adipose tissue by cDNA microarray analysis. Glucocorticoid was one of regulators for adiponectin expression and its regulatory mechanism was clarified in present study.

Research Products

• [Journal Article] Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice (2012)
  • Author(s): Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Maeda N, Sakaue H, Masuzaki H, Shimomura I, Sata M.
  • Journal Title: Cardiovascular Diabetol. Volume: 11 Issue: 1 Pages: 139-139
  • DOI: 10.1186/1475-2840-11-139
  • Peer Reviewed
• [Journal Article] Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction (2012)
  • Author(s): Hirata A, Maeda N, Nakatsuji H, Hiuge-Shimizu A, Okada T, Funahashi T, Shimomura I
  • Journal Title: Biochem Biophys Res Commun Volume: 419 Issue: 2 Pages: 182-187
  • DOI: 10.1016/j.bbrc.2012.01.139
  • Peer Reviewed
• [Journal Article] Adiponectin G276T gene polymorphism is associated with cardiovascular disease in Japanese patients with type 2 diabetes. (2012)
  • Author(s): Katakami N, Kaneto H, Matsuoka TA, Takahara M, Maeda N, Shimizu I, Ohno K, Osonoi T, Kawai K, Ishibashi F, Imamura K, Kashiwagi A, Kawamori R, Matsuhisa M, Funahashi T, Yamasaki Y, Shimomura I.
  • Journal Title: Atherosclerosis. Volume: 220 Issue: 2 Pages: 437-442
  • DOI: 10.1016/j.atherosclerosis.2011.11.010
  • Peer Reviewed
• [Journal Article] A pilot investigation of visceral fat adiposity and gene expression profile in peripheral blood cells. (2012)
  • Author(s): Yamaoka M
  • Journal Title: PLoS One Volume: 7 Issue: 10 Pages: e47377-e47377
  • DOI: 10.1371/journal.pone.0047377
  • Peer Reviewed
• [Journal Article] Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference : a pilot study of obese Japanese patients with type 2 diabetes (2011)
  • Author(s): Inoue K, Maeda N, Kashine S, Fujishima Y, Kozawa J, Hiuge-Shimizu A, Okita K, Imagawa A, Funahashi T, Shimomura I
  • Journal Title: Cardiovasc Diabetol Volume: 10 Issue: 1 Pages: 109-109
  • DOI: 10.1186/1475-2840-10-109
  • Peer Reviewed
• [Journal Article] Induced adipocyte cell-sheet ameliorates cardiac dysfunction in a mouse myocardial infarction model: a novel drug delivery system for heart failure. (2011)
  • Author(s): Imanishi Y, Miyagawa S, Maeda N, Fukushima S, Kitagawa-Sakakida S, Daimon T, Hirata A, Shimizu T, Okano T, Shimomura I, Sawa Y
  • Journal Title: Circulation. Volume: 124 Issue: 11_suppl_1
  • DOI: 10.1161/circulationaha.110.009993
  • Peer Reviewed
• [Journal Article] Right-Sided Acute Suppurative Thyroiditis Caused by Infectious Endocarditis (2011)
  • Author(s): Inoue K, Kozawa J, Funahashi T, Nakata Y, Mitsui E, Kitamura T, Maeda N, Kishida,K, Otsuki M, Okita K, Iwahashi H, Imagawa A, Shimomura I
  • Journal Title: Internal Medicine Volume: 50 Issue: 23 Pages: 2893-2897
  • DOI: 10.2169/internalmedicine.50.5790
  • NAID: 130002062706
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice : implications for therapy (2011)
  • Author(s): 中西香織、武田吉人
  • Journal Title: Am J Respir Criti Care Med Volume: 183 Issue: 9 Pages: 1164-1175
  • DOI: 10.1164/rccm.201007-1091oc
  • Peer Reviewed
• [Journal Article] Dynamic changes of adiponectin and S100A8 levels by the selective peroxisome proliferator-activated receptor-gamma agonist rivoglitazone (2011)
  • Author(s): Hiuge-Shimizu A, Kihara S, et al
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Issue: 4 Pages: 792-799
  • DOI: 10.1161/atvbaha.110.221747
  • Peer Reviewed
• [Journal Article] 肥満症とアディポサイトカイン (2011)
  • Author(s): 前田法一
  • Journal Title: 日本内科学会雑誌 Volume: 100 Pages: 911-916
  • NAID: 10029096603
• [Journal Article] アクアポリン (2011)
  • Author(s): 前田法一
  • Journal Title: 最新医学 Volume: 66 Pages: 1419-1431
• [Journal Article] 心不全とアディポサイエンス～アクアポリンを介した機序～ (2011)
  • Author(s): 前田法一
  • Journal Title: アディポサイエンス Volume: 8 Pages: 25-31
• [Journal Article] Increment and impairment of adiponectin in renal failure. (2010)
  • Author(s): Komura N, Funahashi T, Maeda N., et al.
  • Journal Title: Cardiovasc Res. Volume: 86(3) Pages: 471-477
  • Peer Reviewed
• [Journal Article] Local induction of adiponectin reduces lipopolysaccharide-triggered skeletal muscle damage. (2010)
  • Author(s): Jortay J, Funahashi T, Maeda N., et al.
  • Journal Title: Endocrinology. Volume: 151(10) Pages: 4840-4851
  • Peer Reviewed
• [Journal Article] アディポネクチンの組織集積機構の解明とアディポサイトカイン発現異常改善薬の探索 (2010)
  • Author(s): 前田法一
  • Journal Title: Therapeutic Research Volume: 31 Pages: 789-793
• [Journal Article] アディポネクチンと糖尿病合併症 (2010)
  • Author(s): 前田法一
  • Journal Title: 糖尿病ナビゲーター Volume: 2 Pages: 432-433
• [Journal Article] アディポネクチンとアクアポリンの病態的意義の解明 (2010)
  • Author(s): 前田法一
  • Journal Title: 日本肥満学会誌「肥満研究」 Volume: 16 Pages: 155-162
  • NAID: 10029409603
• [Presentation] Metabolic Impact of Water Channel Proteins (2011)
  • Author(s): Norikazu Maeda
  • Organizer: The First World Congress on Water Channel Proteins Celebrating the 25th Anniversary of the Discovery of the First Water Channel Protein (Aquaporins and Relatives)
  • Place of Presentation: Cluj-Napoca (Romania)(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] アディポサイトカインと慢性炎症 (2011)
  • Author(s): 前田法一
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市(兵庫県)(招待講演)
  • Year and Date: 2011-09-24
• [Presentation] 肥満における脂肪細胞ミネラルコルチコイド受容体の病態意義の検討 (2011)
  • Author(s): 平田歩、前田法一, 他
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市(兵庫県)
  • Year and Date: 2011-09-23
• [Presentation] 肥満2型糖尿病におけるリラグルチドの内臓脂肪・食欲に及ぼす短期的効果の検討 (2011)
  • Author(s): 井上佳菜、前田法一, 他
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市(兵庫県)
  • Year and Date: 2011-09-23
• [Presentation] 当院外来2型糖尿病患者の全身血管エコーの特徴 (2011)
  • Author(s): 平田歩、前田法一, 他
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市(兵庫県)
  • Year and Date: 2011-09-23
• [Presentation] 肥満2型糖尿病の臨床像 (2011)
  • Author(s): 船橋徹、前田法一, 他
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市(兵庫県)
  • Year and Date: 2011-09-23
• [Presentation] リボグリタゾンの動脈硬化、アディポネクチン、S100A8に及ぼす影響 (2011)
  • Author(s): 前田法一
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市(兵庫県)
  • Year and Date: 2011-09-23
• [Presentation] 内臓脂肪研究から治療応用へ (2011)
  • Author(s): 前田法一
  • Organizer: 第16回アディポサイエンス研究会
  • Place of Presentation: 豊中市(大阪府)(招待講演)
  • Year and Date: 2011-08-20
• [Presentation] 肥満2型糖尿病におけるリラグルチドの内臓脂肪・食欲に及ぼす短期的効果の検討 (2011)
  • Author(s): 井上佳菜、前田法一, 他
  • Organizer: 第16回アディポサイエンス研究会
  • Place of Presentation: 豊中市(大阪府)
  • Year and Date: 2011-08-20
• [Presentation] Evaluations of systemic arteriosclerosis and visceral fat accumulation is a useful maneuver for prediction of coronary artery disease in type 2 diabetes (2011)
  • Author(s): Ayumu Hirata, Norikazu Maeda., et al
  • Organizer: The 43rd Annual Scientific Meeting of the Japan Atherosclerosis Society
  • Place of Presentation: Sapporo (Hokkaido)
  • Year and Date: 2011-07-15
• [Presentation] 肥満・非肥満2型糖尿病患者の病態分類によるインクレチン関連薬の有効性の検討 (2011)
  • Author(s): 小澤純二、前田法一, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市(北海道)
  • Year and Date: 2011-05-21
• [Presentation] 当院糖尿病外来患者の全身血管エコーの特徴 (2011)
  • Author(s): 平田歩、前田法一, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市(北海道)
  • Year and Date: 2011-05-21
• [Presentation] 肥満者における内臓脂肪蓄積と末梢血発現遺伝子プロファイルの解析 (2011)
  • Author(s): 山岡正弥、前田法一, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市(北海道)
  • Year and Date: 2011-05-21
• [Presentation] 高度肥満合併糖尿病患者における腹腔鏡下袖状胃切除術の効果 (2011)
  • Author(s): 沖田考平、前田法一, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市(北海道)
  • Year and Date: 2011-05-20
• [Presentation] リラグルチド投与により食行動の変化を認めた2型糖尿病の1例 (2011)
  • Author(s): 大月道夫、前田法一, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市(北海道)
  • Year and Date: 2011-05-20
• [Presentation] オクトレオチド徐放製剤投与中にDPP-4阻害薬を使用し耐糖能改善を認めた先端巨大症の1例 (2011)
  • Author(s): 田渕優希子、前田法一, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市(北海道)
  • Year and Date: 2011-05-19
• [Presentation] Role of aquaporin 7 in glycerol metabolism (2011)
  • Author(s): Norikazu Maeda
  • Organizer: The 6^<th> International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects 1-2 April, 2011
  • Place of Presentation: Kyoto (Japan)(招待講演)
  • Year and Date: 2011-04-01
• [Presentation] Constitutive Adiponectin Administration Using Adipocyte Sheet-based Drug Delivery System Ameliorates Cardiac Dysfunction in Mouse Myocardial Infarction Model. (2010)
  • Author(s): Yukiko Imanishi, Norikazu Maeda., et al.
  • Organizer: The American Heart Association's Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-10-13
• [Presentation] アディポネクチンとアクアポリンの病態的意義の解明 (2010)
  • Author(s): 前田法一
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)(招待講演)
  • Year and Date: 2010-10-02
• [Presentation] 腎不全におけるアディポネクチン濃度上昇と機能障害機序 (2010)
  • Author(s): 小村徳幸、前田法一, 他
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)
  • Year and Date: 2010-10-02
• [Presentation] グルココルチコイドが脂肪細胞コルチコイド受容体に及ぼす影響 (2010)
  • Author(s): 平田歩、前田法一, 他
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)
  • Year and Date: 2010-10-01
• [Presentation] 脂肪細胞ナトリウム利尿ペプチド受容体のインスリンによる調節 (2010)
  • Author(s): 中辻秀朗、前田法一, 他
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)
  • Year and Date: 2010-10-01
• [Presentation] 脂肪細胞ナトリウム利尿ペプチド受容体のインスリンによる制御 (2010)
  • Author(s): 中辻秀朗、前田法一, 他
  • Organizer: The 15th Adiposcience Symposium
  • Place of Presentation: 千里阪急ホテル(大阪府)
  • Year and Date: 2010-08-21
• [Presentation] The impact of glucocorticoid on mineralocorticoid receptor in adipocytes (2010)
  • Author(s): 平田歩、前田法一, 他
  • Organizer: The 15th Adiposcience Symposium
  • Place of Presentation: 千里阪急ホテル(大阪府)
  • Year and Date: 2010-08-21
• [Presentation] 腎不全におけるアディポネクチン濃度上昇と機能障害機序 (2010)
  • Author(s): 小村徳幸、前田法一, 他
  • Organizer: The 15th Adiposcience Symposium
  • Place of Presentation: 千里阪急ホテル(大阪府)
  • Year and Date: 2010-08-21
• [Presentation] Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. (2010)
  • Author(s): Ayumu Hirata, Tohru Funahashi, Norikazu Maeda., et al.
  • Organizer: 11th International Congress on Obesity
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-07-12
• [Presentation] Impaired adiponectin clearance and function in renal failure model. (2010)
  • Author(s): Noriyuki Komura, Tohru Funahashi, Norikazu Maeda., et al.
  • Organizer: 11th International Congress on Obesity
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-07-12
• [Presentation] 新規チアゾリジン誘導体リボグリタゾンのアディポネクチンに与える影響 (2010)
  • Author(s): 日生下亜紀、前田法一, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: ホテルグランヴィア岡山 (岡山県)
  • Year and Date: 2010-05-29
• [Presentation] 脂肪肝臓におけるDEPP (decidual protein induced by progesterone)発現の意義 (2010)
  • Author(s): 黒田陽平、前田法一, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市デジタルミュージアム (岡山県)
  • Year and Date: 2010-05-28
• [Presentation] グルココルチコイドによる脂肪細胞ミネラルコルチコイド受容体活性化の意義 (2010)
  • Author(s): 平田歩、前田法一, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市デジタルミュージアム (岡山県)
  • Year and Date: 2010-05-27
• [Presentation] Novel insights in adipocytokines and cardiovascular disease : Is adiponectin a key player in cardiovascular disease? (2010)
  • Author(s): Norikazu Maeda
  • Organizer: XXth World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan(招待講演)
  • Year and Date: 2010-05-16
• [Presentation] P-1-38 Stem cells, progenitor cell, and gene & cell therapy (2); poster presentation : Adiponectin continuous delivery systemby adipocyte sheet implantation attenuates cardiac dysfunction after acute myocardial infarction. (2010)
  • Author(s): Yukiko Imanishi, Norikazu Maeda., et al.
  • Organizer: XXth World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] 肥満における脂肪細胞ミネラルコルチコイド受容体の病態意義の検討
  • Author(s): 平田歩
  • Organizer: 第８５回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] メタボリックシンドローム発症・進展に関わる分子基盤の解明
  • Author(s): 前田法一
  • Organizer: 第８５回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Invited
• [Presentation] PPARgammaアゴニスト・リボグリタゾンによるアディポネクチンおよびS100A8への効果
  • Author(s): 前田法一
  • Organizer: 第５５回日本糖尿病学会年次学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] アディポサイトカインと動脈硬化
  • Author(s): 前田法一
  • Organizer: 第４４回日本動脈硬化学会総会・学術集会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県）
  • Invited
• [Presentation] AdiponectinとAdipomedicine
  • Author(s): 前田法一
  • Organizer: 第３３回日本肥満学会
  • Place of Presentation: ホテルグランヴィア京都（京都府）
  • Invited
• [Book] 月刊糖尿病「メタボリックシンドロームにおける心筋代謝」 (2013)
  • Author(s): 前田法一
  • Total Pages: 7
  • Publisher: 医学出版
• [Book] 最新臨床糖尿病学「糖尿病の検査・診断法：アディポサイトカイン」 (2012)
  • Author(s): 前田法一
  • Total Pages: 4
  • Publisher: 日本臨床社