Evaluation of the effects of the accumulation of gene polymorphismsrelated to oxidative stress on diabetic macroangiopathy

• Project/Area Number: 22590980
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka University
• Principal Investigator: KATAKAMI Naoto 大阪大学, 医学(系)研究科, 助教 (10403049)
• Co-Investigator(Kenkyū-buntansha): MATSUOKA Takaaki 大阪大学, 医学(系)研究科, 助教 (10379258) ; YASUDA Tetsuyuki 大阪大学, 医学(系)研究科, 助教 (30448055) ; KANETO Hideaki 大阪大学, 医学(系)研究科, 准教授 (80448034)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糖尿病 / 糖尿病大血管症 / 酸化ストレス / 遺伝子診断 / SNP

Research Abstract

Accumulation of gene polymorphisms related to oxidative stress is likely associated with the prevalence of myocardial infarction in type 2 diabetic patients, suggesting that the combined information about these variants is useful to assess the risk of myocardial infarction.

Research Products

• [Journal Article] Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients (2010)
  • Author(s): Katakami N, Kaneto H, Matsuoka TA
  • Journal Title: Atherosclerosis Volume: 201 Pages: 534-538
  • Peer Reviewed
• [Journal Article] Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients. (2010)
  • Author(s): Katakami N, Kaneto H, et al.
  • Journal Title: Atherosclerosis Volume: 212 Pages: 534-538
  • Peer Reviewed
• [Presentation] 遺伝因子とオーダーメイド医療の可能性 (2012)
  • Author(s): 片上直人
  • Organizer: 第27回日本糖尿病合併症学会年次学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-11-02
• [Presentation] 酸化ストレスに関連する遺伝子多型の集積は心筋梗塞に関連する (2011)
  • Author(s): 片上直人
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] 酸化ストレスに関連する遺伝子多型の集積は心筋梗塞に関連する (2011)
  • Author(s): 片上直人, ほか
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌フリンスホテル(札幌市)
  • Year and Date: 2011-05-20