| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
GCN2 is a molecule activated by amino acid deficiency. We generated generalized GCN2 knockout mice (GCN2-/- mice). GCN2-/- mice fed a high-fat diet (HFD) exhibited significant aggravation in glucose tolerance and reduction in pancreatic ・-cell mass. Our results showed that chronic activation of mTORC1 signal is one of the causes of reduction in pancreatic ・-cell mass in GCN2-/- mice. In islets from mice fed a HFD, the activation of GCN2, caused by the enhancement of translation of insulin, might contribute to maintenance of pancreatic ・-cell mass.
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